EC number:2.7.7.3
Enzyme
Download| EC Tree |
| 2. Transferases |
| 2.7 Transferring phosphorus-containing groups |
| 2.7.7 Nucleotidyltransferases |
| ID: | 2.7.7.3 |
|---|---|
| Description: | Pantetheine-phosphate adenylyltransferase. |
| Alternative Name: |
PPAT. Phosphopantetheine adenylyltransferase. Dephospho-coenzyme A pyrophosphorylase. Dephospho-CoA pyrophosphorylase. Dephospho-CoA diphosphorylase. 3'-dephospho-CoA pyrophosphorylase. |
| Cath: | 3.40.50.620; 3.40.50.300; |
3D structure
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External Links
| UniProtKB Enzyme Link: | UniProtKB 2.7.7.3 |
| BRENDA Enzyme Link: | BRENDA 2.7.7.3 |
| KEGG Enzyme Link: | KEGG2.7.7.3 |
| BioCyc Enzyme Link: | BioCyc 2.7.7.3 |
| ExPASy Enzyme Link: | ExPASy2.7.7.3 |
| EC2PDB Enzyme Link: | EC2PDB 2.7.7.3 |
| ExplorEnz Enzyme Link: | ExplorEnz 2.7.7.3 |
| PRIAM enzyme-specific profiles Link: | PRIAM 2.7.7.3 |
| IntEnz Enzyme Link: | IntEnz 2.7.7.3 |
| MEDLINE Enzyme Link: | MEDLINE 2.7.7.3 |
| RHEA:19801 | ATP + D-pantetheine 4'-phosphate + H(+) = 3'-dephospho-CoA + diphosphate |
| RULE(radius=1) | [*:1]-[OH;+0:2].[*:3]=[P;H0;+0:4](-[*:5])(-[*:6])-[O;H0;+0:7]-[*:8].[H+;H0:9]>>[*:8]-[OH;+0:7].[*:3]=[P;H0;+0:4](-[*:5])(-[*:6])-[O;H0;+0:2]-[*:1] |
| Reaction |  |
| Core-to-Core | No scaffolds atoms were exchanged as a result of the reaction |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Separate enzymes catalyze the final two steps of coenzyme A biosynthesis in Brevibacterium ammoniagenes: purification of pantetheine phosphate adenylyltransferase. | Martin DP, Drueckhammer DG | 1993 May 14 | 8389542 |
| Biosynthesis of coenzyme A from phospho-pantetheine and of pantetheine from pantothenate. | HOAGLAND MB, NOVELLI GD | 1954 Apr | 13163064 |
| Enzymatic synthesis and structure of CoA. | NOVELLI GD | 1953 Sep | 13107738 |
| Purification and characterization of phosphopantetheine adenylyltransferase from Escherichia coli. | Geerlof A, Lewendon A, Shaw WV | 1999 Sep 17 | 10480925 |
| Cubic crystals of phosphopantetheine adenylyltransferase from Escherichia coli. | Izard T, Geerlof A, Lewendon A, Barker JJ | 1999 Jun | 10329792 |