EC number:2.7.7.38
Enzyme
Download| EC Tree |
| 2. Transferases |
| 2.7 Transferring phosphorus-containing groups |
| 2.7.7 Nucleotidyltransferases |
| ID: | 2.7.7.38 |
|---|---|
| Description: | 3-deoxy-manno-octulosonate cytidylyltransferase. |
| Alternative Name: |
CMP-KDO synthetase. CMP-3-deoxy-D-manno-octulosonate pyrophosphorylase. CMP-3-deoxy-D-manno-octulosonate diphosphorylase. CMP-2-keto-3-deoxyoctulosonic acid synthetase. |
| Cath: | 3.90.550.10; |
3D structure
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External Links
| UniProtKB Enzyme Link: | UniProtKB 2.7.7.38 |
| BRENDA Enzyme Link: | BRENDA 2.7.7.38 |
| KEGG Enzyme Link: | KEGG2.7.7.38 |
| BioCyc Enzyme Link: | BioCyc 2.7.7.38 |
| ExPASy Enzyme Link: | ExPASy2.7.7.38 |
| EC2PDB Enzyme Link: | EC2PDB 2.7.7.38 |
| ExplorEnz Enzyme Link: | ExplorEnz 2.7.7.38 |
| PRIAM enzyme-specific profiles Link: | PRIAM 2.7.7.38 |
| IntEnz Enzyme Link: | IntEnz 2.7.7.38 |
| MEDLINE Enzyme Link: | MEDLINE 2.7.7.38 |
| RHEA:23448 | 3-deoxy-alpha-D-manno-oct-2-ulosonate + CTP = CMP-3-deoxy-beta-D-manno-octulosonate + diphosphate |
| RULE(radius=1) | [*:1]-[OH;+0:2].[*:3]-[P;H0;+0:4](=[*:5])(-[*:6])-[O;H0;+0:7]-[*:8]>>[*:8]-[OH;+0:7].[*:3]-[P;H0;+0:4](=[*:5])(-[*:6])-[O;H0;+0:2]-[*:1] |
| Reaction |  |
| Core-to-Core | |
| Core-to-Core |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| The biosynthesis of cell wall lipopolysaccharide in Escherichia coli. IV. Purification and properties of cytidine monophosphate 3-deoxy-d-manno-octulosonate synthetase. | Ghalambor MA, Heath EC | 1966 Jul 10 | 5330266 |
| Cloning and characterization of cytidine monophosphate-3-deoxy-d-manno-octulosonate synthetase from Arabidopsis thaliana. | Misaki R, Kajiura H, Fujii K, Fujiyama K, Seki T | 2009 Dec | 19914588 |
| Structure-based mechanism of CMP-2-keto-3-deoxymanno-octulonic acid synthetase: convergent evolution of a sugar-activating enzyme with DNA/RNA polymerases. | Heyes DJ, Levy C, Lafite P, Roberts IS, Goldrick M, Stachulski AV, Rossington SB, Stanford D, Rigby SE, Scrutton NS, Leys D | 2009 Dec 18 | 19815542 |
| Structure of 3-deoxy-manno-octulosonate cytidylyltransferase from Haemophilus influenzae complexed with the substrate 3-deoxy-manno-octulosonate in the beta-configuration. | Yoon HJ, Ku MJ, Mikami B, Suh SW | 2008 Dec | 19018107 |
| Catalytic mechanism of CMP:2-keto-3-deoxy-manno-octonic acid synthetase as derived from complexes with reaction educt and product. | Jelakovic S, Schulz GE | 2002 Jan 29 | 11802716 |