EC number:2.7.7.4
Enzyme
Download| EC Tree |
| 2. Transferases |
| 2.7 Transferring phosphorus-containing groups |
| 2.7.7 Nucleotidyltransferases |
| ID: | 2.7.7.4 |
|---|---|
| Description: | Sulfate adenylyltransferase. |
| Alternative Name: |
Sulfurylase. Sulfate adenylate transferase. ATP-sulfurylase. |
| Cath: | 3.40.50.620; 2.40.30.10; 3.40.50.300; 3.10.400.10; |
3D structure
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External Links
| UniProtKB Enzyme Link: | UniProtKB 2.7.7.4 |
| BRENDA Enzyme Link: | BRENDA 2.7.7.4 |
| KEGG Enzyme Link: | KEGG2.7.7.4 |
| BioCyc Enzyme Link: | BioCyc 2.7.7.4 |
| ExPASy Enzyme Link: | ExPASy2.7.7.4 |
| EC2PDB Enzyme Link: | EC2PDB 2.7.7.4 |
| ExplorEnz Enzyme Link: | ExplorEnz 2.7.7.4 |
| PRIAM enzyme-specific profiles Link: | PRIAM 2.7.7.4 |
| IntEnz Enzyme Link: | IntEnz 2.7.7.4 |
| MEDLINE Enzyme Link: | MEDLINE 2.7.7.4 |
| RHEA:18133 | ATP + H(+) + sulfate = adenosine 5'-phosphosulfate + diphosphate |
| RULE(radius=1) | [*:1]-[OH;+0:2].[*:3]=[P;H0;+0:4](-[*:5])(-[*:6])-[O;H0;+0:7]-[*:8].[H+;H0:9]>>[*:8]-[OH;+0:7].[*:3]=[P;H0;+0:4](-[*:5])(-[*:6])-[O;H0;+0:2]-[*:1] |
| Reaction |  |
| Core-to-Core | No scaffolds atoms were exchanged as a result of the reaction |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Molecular cloning, expression, and characterization of human bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase and its functional domains. | Venkatachalam KV, Akita H, Strott CA | 1998 Jul 24 | 9668121 |
| The isolation and characterization of cDNA encoding the mouse bifunctional ATP sulfurylase-adenosine 5'-phosphosulfate kinase. | Li H, Deyrup A, Mensch JR Jr, Domowicz M, Konstantinidis AK, Schwartz NB | 1995 Dec 8 | 7493984 |
| Adenosine-5'-triphosphate-sulfurylase from Arabidopsis thaliana and Escherichia coli are functionally equivalent but structurally and kinetically divergent: nucleotide sequence of two adenosine-5'-triphosphate-sulfurylase cDNAs from Arabidopsis thaliana and analysis of a recombinant enzyme. | Murillo M, Leustek T | 1995 Oct 20 | 7487067 |
| Enzymatic mechanisms of phosphate and sulfate transfer. | Cleland WW, Hengge AC | 2006 Aug | 16895327 |
| Anatomy of an energy-coupling mechanism--the interlocking catalytic cycles of the ATP sulfurylase-GTPase system. | Sun M, Leyh TS | 2005 Oct 25 | 16229483 |
| Expression, purification and crystallization of human 3'-phosphoadenosine-5'-phosphosulfate synthetase 1. | Harjes S, Scheidig A, Bayer P | 2004 Feb | 14747722 |
| Crystal structure of ATP sulfurylase from Saccharomyces cerevisiae, a key enzyme in sulfate activation. | Ullrich TC, Blaesse M, Huber R | 2001 Feb 1 | 11157739 |