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2. Transferases

2.7 Transferring phosphorus-containing groups

2.7.7 Nucleotidyltransferases

ID:

2.7.7.41

Description:

Phosphatidate cytidylyltransferase.

Alternative Name:

CDP-diglyceride synthetase.
CDP-diglyceride pyrophosphorylase.
CDP-diglyceride diphosphorylase.
CDP-diacylglycerol synthase.

Prosite:

PDOC01019;

PDB:

PDB	Scop
4Q2G

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PDB	Click once to unfold,double click to fold. 4Q2G;

UniProtKB Enzyme Link:	UniProtKB 2.7.7.41
BRENDA Enzyme Link:	BRENDA 2.7.7.41
KEGG Enzyme Link:	KEGG2.7.7.41
BioCyc Enzyme Link:	BioCyc 2.7.7.41
ExPASy Enzyme Link:	ExPASy2.7.7.41
EC2PDB Enzyme Link:	EC2PDB 2.7.7.41
ExplorEnz Enzyme Link:	ExplorEnz 2.7.7.41
PRIAM enzyme-specific profiles Link:	PRIAM 2.7.7.41
IntEnz Enzyme Link:	IntEnz 2.7.7.41
MEDLINE Enzyme Link:	MEDLINE 2.7.7.41

RHEA:16229	a 1,2-diacyl-sn-glycero-3-phosphate + CTP + H(+) = a CDP-1,2-diacyl-sn-glycerol + diphosphate
RULE(radius=1)	[:1]-[OH;+0:2].[:3]-[P;H0;+0:4](=[:5])(-[:6])-[O;H0;+0:7]-[:8].[H+;H0:9]>>[:8]-[OH;+0:7].[:3]-[P;H0;+0:4](=[:5])(-[:6])-[O;H0;+0:2]-[:1]
Reaction
Core-to-Core	No scaffolds atoms were exchanged as a result of the reaction

Title	Authors	Date	PubMed ID
The CDS1 gene encoding CDP-diacylglycerol synthase in Saccharomyces cerevisiae is essential for cell growth.	Shen H, Heacock PN, Clancey CJ, Dowhan W	1996 Jan 12	8557688
Tam41 is a CDP-diacylglycerol synthase required for cardiolipin biosynthesis in mitochondria.	Tamura Y, Harada Y, Nishikawa S, Yamano K, Kamiya M, Shiota T, Kuroda T, Kuge O, Sesaki H, Imai K, Tomii K, Endo T	2013 May 7	23623749
Mitochondrial CDP-diacylglycerol synthase activity is due to the peripheral protein, TAMM41 and not due to the integral membrane protein, CDP-diacylglycerol synthase 1.	Blunsom NJ, Gomez-Espinosa E, Ashlin TG, Cockcroft S	2018 Mar	29253589