EC number:2.7.7.43
Enzyme
Download| EC Tree |
| 2. Transferases |
| 2.7 Transferring phosphorus-containing groups |
| 2.7.7 Nucleotidyltransferases |
| ID: | 2.7.7.43 |
|---|---|
| Description: | N-acylneuraminate cytidylyltransferase. |
| Alternative Name: |
CMP-sialic acid synthetase. CMP-sialate synthase. CMP-sialate pyrophosphorylase. CMP-sialate diphosphorylase. CMP-NeuNAc synthetase. CMP-N-acetylneuraminic acid synthetase. |
| Cath: | 3.90.550.10; 3.40.50.1000; |
3D structure
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External Links
| UniProtKB Enzyme Link: | UniProtKB 2.7.7.43 |
| BRENDA Enzyme Link: | BRENDA 2.7.7.43 |
| KEGG Enzyme Link: | KEGG2.7.7.43 |
| BioCyc Enzyme Link: | BioCyc 2.7.7.43 |
| ExPASy Enzyme Link: | ExPASy2.7.7.43 |
| EC2PDB Enzyme Link: | EC2PDB 2.7.7.43 |
| ExplorEnz Enzyme Link: | ExplorEnz 2.7.7.43 |
| PRIAM enzyme-specific profiles Link: | PRIAM 2.7.7.43 |
| IntEnz Enzyme Link: | IntEnz 2.7.7.43 |
| MEDLINE Enzyme Link: | MEDLINE 2.7.7.43 |
| RHEA:11344 | an N-acylneuraminate + CTP = a CMP-N-acyl-beta-neuraminate + diphosphate |
| RULE(radius=1) | [*:1]-[OH;+0:2].[*:3]-[P;H0;+0:4](=[*:5])(-[*:6])-[O;H0;+0:7]-[*:8]>>[*:8]-[OH;+0:7].[*:3]-[P;H0;+0:4](=[*:5])(-[*:6])-[O;H0;+0:2]-[*:1] |
| Reaction |  |
| Core-to-Core | |
| Core-to-Core |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Mammalian cytidine 5'-monophosphate N-acetylneuraminic acid synthetase: a nuclear protein with evolutionarily conserved structural motifs. | Münster AK, Eckhardt M, Potvin B, Mühlenhoff M, Stanley P, Gerardy-Schahn R | 1998 Aug 4 | 9689047 |
| Characterization of cpsF and its product CMP-N-acetylneuraminic acid synthetase, a group B streptococcal enzyme that can function in K1 capsular polysaccharide biosynthesis in Escherichia coli. | Haft RF, Wessels MR, Mebane MF, Conaty N, Rubens CE | 1996 Feb | 8830246 |
| Purification, properties, and genetic location of Escherichia coli cytidine 5'-monophosphate N-acetylneuraminic acid synthetase. | Vann WF, Silver RP, Abeijon C, Chang K, Aaronson W, Sutton A, Finn CW, Lindner W, Kotsatos M | 1987 Dec 25 | 2826425 |
| Identification and characterization of important residues in the catalytic mechanism of CMP-Neu5Ac synthetase from Neisseria meningitidis. | Horsfall LE, Nelson A, Berry A | 2010 Jul | 20491913 |
| Nuclear localization signal of murine CMP-Neu5Ac synthetase includes residues required for both nuclear targeting and enzymatic activity. | Munster AK, Weinhold B, Gotza B, Muhlenhoff M, Frosch M, Gerardy-Schahn R | 2002 May 31 | 11893746 |
| Cloning and expression of human sialic acid pathway genes to generate CMP-sialic acids in insect cells. | Lawrence SM, Huddleston KA, Tomiya N, Nguyen N, Lee YC, Vann WF, Coleman TA, Betenbaugh MJ | 2001 Mar | 11602804 |
| Kinetic properties of the acylneuraminate cytidylyltransferase from Pasteurella haemolytica A2. | Bravo IG, Barrallo S, Ferrero MA, Rodríguez-Aparicio LB, Martínez-Blanco H, Reglero A | 2001 Sep 15 | 11577688 |
| Molecular cloning of a unique CMP-sialic acid synthetase that effectively utilizes both deaminoneuraminic acid (KDN) and N-acetylneuraminic acid (Neu5Ac) as substrates. | Nakata D, Münster AK, Gerardy-Schahn R, Aoki N, Matsuda T, Kitajima K | 2001 Aug | 11479279 |
| Investigation of the kinetic mechanism of cytidine 5'-monophosphate N-acetylneuraminic acid synthetase from Haemophilus ducreyi with new insights on rate-limiting steps from product inhibition analysis. | Samuels NM, Gibson BW, Miller SM | 1999 May 11 | 10320348 |