EC number:2.7.7.52

Enzyme

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     2. Transferases
        2.7 Transferring phosphorus-containing groups
            2.7.7 Nucleotidyltransferases
ID:2.7.7.52
Description:RNA uridylyltransferase.
Alternative Name: TUT.
Terminal uridylyltransferase.
Cath: 1.10.1410.10; 3.30.460.10; 3.30.70.330;

3D structure

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PDB

References

External Links

UniProtKB Enzyme Link: UniProtKB 2.7.7.52
BRENDA Enzyme Link: BRENDA 2.7.7.52
KEGG Enzyme Link: KEGG2.7.7.52
BioCyc Enzyme Link: BioCyc 2.7.7.52
ExPASy Enzyme Link: ExPASy2.7.7.52
EC2PDB Enzyme Link: EC2PDB 2.7.7.52
ExplorEnz Enzyme Link: ExplorEnz 2.7.7.52
PRIAM enzyme-specific profiles Link: PRIAM 2.7.7.52
IntEnz Enzyme Link: IntEnz 2.7.7.52
MEDLINE Enzyme Link: MEDLINE 2.7.7.52

EC number:2.7.7.52

MSA:

2.7.7.52;
Phylogenetic Tree:

2.7.7.52;
Uniprot:
M-CSA:
RHEA:14785 RNA(n) + UTP = diphosphate + RNA(n)-3'-uridine ribonucleotide
RULE(radius=1) [*:1]-[OH;+0:2].[*:3]-[P;H0;+0:4](=[*:5])(-[*:6])-[O;H0;+0:7]-[*:8]>>[*:8]-[OH;+0:7].[*:3]-[P;H0;+0:4](=[*:5])(-[*:6])-[O;H0;+0:2]-[*:1]
Reaction
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References

TitleAuthorsDatePubMed ID
Terminal uridylyl transferase of Vigna unguiculata: purification and characterization of an enzyme catalyzing the addition of a single UMP residue to the 3'-end of an RNA primer.Zabel P, Dorssers L, Wernars K, Van Kammen A1981 Jun 116269049
Distinct and cooperative activities of HESO1 and URT1 nucleotidyl transferases in microRNA turnover in Arabidopsis.Tu B, Liu L, Xu C, Zhai J, Li S, Lopez MA, Zhao Y, Yu Y, Ramachandran V, Ren G, Yu B, Li S, Meyers BC, Mo B, Chen X2015 Apr25928405
Structural plasticity of Cid1 provides a basis for its distributive RNA terminal uridylyl transferase activity.Yates LA, Durrant BP, Fleurdépine S, Harlos K, Norbury CJ, Gilbert RJ2015 Mar 1125712096
A critical switch in the enzymatic properties of the Cid1 protein deciphered from its product-bound crystal structure.Munoz-Tello P, Gabus C, Thore S2014 Mar24322298
Uridylation prevents 3' trimming of oligoadenylated mRNAs.Sement FM, Ferrier E, Zuber H, Merret R, Alioua M, Deragon JM, Bousquet-Antonelli C, Lange H, Gagliardi D2013 Aug23748567
Crystal structures of the Cid1 poly (U) polymerase reveal the mechanism for UTP selectivity.Lunde BM, Magler I, Meinhart A2012 Oct22885303
Structural basis for the activity of a cytoplasmic RNA terminal uridylyl transferase.Yates LA, Fleurdépine S, Rissland OS, De Colibus L, Harlos K, Norbury CJ, Gilbert RJC2012 Aug22751018
TUT4 in concert with Lin28 suppresses microRNA biogenesis through pre-microRNA uridylation.Heo I, Joo C, Kim YK, Ha M, Yoon MJ, Cho J, Yeom KH, Han J, Kim VN2009 Aug 2119703396
Zcchc11-dependent uridylation of microRNA directs cytokine expression.Jones MR, Quinton LJ, Blahna MT, Neilson JR, Fu S, Ivanov AR, Wolf DA, Mizgerd JP2009 Sep19701194
Decapping is preceded by 3' uridylation in a novel pathway of bulk mRNA turnover.Rissland OS, Norbury CJ2009 Jun19430462
A family of poly(U) polymerases.Kwak JE, Wickens M2007 Jun17449726
Efficient RNA polyuridylation by noncanonical poly(A) polymerases.Rissland OS, Mikulasova A, Norbury CJ2007 May17353264