EC number:2.7.7.6

Enzyme

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     2. Transferases
        2.7 Transferring phosphorus-containing groups
            2.7.7 Nucleotidyltransferases
ID:2.7.7.6
Description:DNA-directed RNA polymerase.
Alternative Name: RNA polymerase III.
RNA polymerase II.
RNA polymerase I.
RNA nucleotidyltransferase (DNA-directed).
DNA-dependent RNA polymerase.
Prosite: PDOC00106; PDOC00896; PDOC00889; PDOC00856; PDOC00855; PDOC00854; PDOC00790; PDOC00411; PDOC00410;
PDB:
PDBScop
5OIK 8080900; 8080901; 8027470; 8039849;
5FLM 8080900; 8080901;
6GMH 8080898; 8080899; 8027470; 8039849;
6EXV 8080898; 8080899;
3H0G 8080894; 8080895; 8080894; 8080895;
 » show all
Cath: 1.10.10.10; 1.10.10.1950; 1.10.10.1980; 1.10.10.1990; 1.10.10.60; 1.10.10.870; 1.10.10.930; 1.10.1220.10; 1.10.1220.100; 1.10.132.30;

3D structure

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PDB

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5OIK; 5FLM; 6GMH; 6EXV; 3H0G; 6C6U; 5U0S; 5MY1; 5LVF; 3D9O; 5SVA; 5IY6; 4GWQ; 4A93; 5C4A; 4BBS; 3PO3; 1Y1Y; 1XPP; 5IYD; 3HOZ; 2R92; 4X67; 3S1N; 5M5X; 6I84; 4A3C; 3J0K; 2E2I; 6F44; 6HLS; 6EU2; 5W64; 5OA1; 5N61; 5FJA; 4C3I; 5VVS; 5U5Q; 5OT2; 4BY7; 4BXX; 4A3J; 4A3E; 3HOX; 2VUM; 2R7Z; 2JA5; 1Y1W; 6BLO; 3S2H; 3S1Q; 3S14; 3M4O; 3GTQ; 3CQZ; 2YU9; 2NVX; 1TWA; 1R9S; 1R5U; 1I3Q; 4V1O; 1PQV; 3GTM; 2JA6; 5W4U; 5N60; 5VVR; 5IP9; 5C44; 4BY1; 4A3M; 4A3I; 4A3D; 3I4N; 3HOW; 3H3V; 1WCM; 6BM2; 3RZD; 3K7A; 3GTP; 3GTL; 3GTK; 3GTG; 2NVQ; 2E2J; 1SFO; 1I6H; 1I50; 5C4X; 5C3E; 4BBR; 4A3K; 4A3F; 3HOY; 3FKI; 2B8K; 6BM4; 6BLP; 5C4J; 3S2D; 3S1R; 3S1M; 3S16; 3M3Y; 2NVY; 2NVT; 1TWG; 1R9T; 1K83; 3HOU; 2JA7; 1TWF; 3QT1; 5IP7; 4BXZ; 4A3L; 4A3G; 4A3B; 3K1F; 3I4M; 3HOV; 2R93; 2JA8; 2B63; 1Y77; 1NT9; 5OQJ; 6BQF; 5W51; 4Y52; 4X6A; 4V1M; 3S17; 3GTO; 3GTJ; 2NVZ; 2E2H; 1TWH; 1TWC; 1NIK; 6F42; 6EU0; 6HLR; 6HLQ; 6H68; 6H67; 6EU1; 5W66; 5W5Y; 5N5Z; 5N5Y; 5M64; 5M5Y; 5M3F; 5LMX; 5G5L; 5FJ9; 4C3H; 6CNF; 6CND; 4C2M; 5W1T; 5VSW; 6GML; 3EQL; 2A68; 1ZYR; 5D4D; 5TMC; 4OIQ; 4MQ9; 5I2D; 5XJ0; 5VO8; 4OIO; 4OIN; 3DXJ; 5VOI; 4Q4Z; 5E17; 2A6E; 4G7Z; 4Q5S; 5TMF; 4OIP; 3WOD; 4GZZ; 4GZY; 2A69; 1IW7; 2PPB; 2O5I; 5X22; 5E18; 4OIR; 5D4E; 4G7H; 2CW0; 2BE5; 4WQS; 6ASG; 5D4C; 4G7O; 2A6H; 2O5J; 4WQT; 3AOI; 3AOH; 5X21; 1SMY; 5IYA; 4YLO; 4YLN; 4YG2; 4YFX; 4YFN; 4YFK; 4XSZ; 4XSY; 4XSX; 5UAH; 5W1S; 4MEY; 4KN7; 4JK1; 1S0V; 1H38; 4RNP; 3E3J; 1ARO; 3E2E; 2PI5; 2PI4; 1S77; 1S76; 1QLN; 1MSW; 1CEZ; 5IY9; 6GYL; 5FYW; 5FMF; 6GYM; 6CNB; 4V1N; 6GYK; 5FZ5; 6F41; 1Y1V; 1EF4; 5IY7; 1QKL; 6F40; 6HKO; 6EU3; 5W65; 5M5W; 5M3M; 5FJ8; 4C3J; 3J1N; 4Y7N; 3S15; 3RZO; 6CNC; 1DZF; 1EIK; 4KN4; 4KMU; 4JK2; 6BYU; 5UAL; 5UAJ; 5UAG; 5UAQ; 4ZH4; 4ZH3; 6CA0; 6C9Y; 5VT0; 4YLP; 6CUX; 5UAC; 4S20; 6N61; 6N60; 6GH6; 6GFW; 6FLP; 6C6T; 6C6S; 6BJS; 6ASX; 6ALH; 6ALG; 6ALF; 5NSS; 5NSR; 5IPN; 5IPM; 5IPL; 3LU0; 4MEX; 6GH5; 5NWT; 6FLQ; 5EZK; 5BYH; 5TJG; 1I6V; 4XLP; 2GHO; 1L9U; 5OQM; 4XLQ; 1HQM; 1YNN; 4XLS; 1L9Z; 4XLR; 4XLN; 1YNJ; 5IYB; 5IY8; 5IYC; 3IYD; 6M7J; 6FED; 6FBV; 6F6W; 6EYD; 6ERQ; 6ERP; 6EEC; 6EE8; 6EDT; 6DVE; 6DVD; 6DVC; 6DVB; 6DV9; 6DCF; 6CCV; 6CCE; 6C06; 6C05; 6C04; 6BZO; 5ZX3; 5ZX2; 5VI8; 5VI5; 5UHG; 5UHF; 5UHE; 5UHD; 5UHC; 5UHB; 5UHA; 5UH9; 5UH8; 5UH6; 5UH5; 5TW1; 5OLA; 4ZH2; 4QJV; 4QIW; 4BOC; 3SPA; 3PO2; 3HKZ; 2PMZ; 2PA8;

References

External Links

UniProtKB Enzyme Link: UniProtKB 2.7.7.6
BRENDA Enzyme Link: BRENDA 2.7.7.6
KEGG Enzyme Link: KEGG2.7.7.6
BioCyc Enzyme Link: BioCyc 2.7.7.6
ExPASy Enzyme Link: ExPASy2.7.7.6
EC2PDB Enzyme Link: EC2PDB 2.7.7.6
ExplorEnz Enzyme Link: ExplorEnz 2.7.7.6
PRIAM enzyme-specific profiles Link: PRIAM 2.7.7.6
IntEnz Enzyme Link: IntEnz 2.7.7.6
MEDLINE Enzyme Link: MEDLINE 2.7.7.6

EC number:2.7.7.6

MSA:

2.7.7.6;
Phylogenetic Tree:

2.7.7.6;
Uniprot:
M-CSA:
RHEA:21248 a ribonucleoside 5'-triphosphate + RNA(n) = diphosphate + RNA(n+1)
RULE(radius=1) [*:1]-[O;H0;+0:2]-[P;H0;+0:3](=[*:4])(-[*:5])-[*:6].([*:7]-[OH;+0:8].[*:9]=[P;H0;+0:10](-[*:11])(-[*:12])-[O;H0;+0:13]-[*:14])>>([*:7]-[O;H0;+0:8]-[P;H0;+0:3](=[*:4])(-[*:5])-[*:6].[*:9]=[P;H0;+0:10](-[*:11])(-[*:12])-[O;H0;+0:2]-[*:1]).[*:14]-[OH;+0:13]
Reaction
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References

TitleAuthorsDatePubMed ID
Molecular structures of DNA-dependent RNA polymerases (II) from calf thymus and rat liver.Weaver RF, Blatti SP, Rutter WJ1971 Dec5289245
Transfer RNA-primed oligoadenylate synthesis in maize seedlings. II. Primer, substrate and metal specificities and size of product.Mans RJ, Walter TJ1971 Sep 304946277
Detection of polyadenylic acid sequences in viral and eukaryotic RNA(polu(U)-cellulose columns-poly(U) filters-fiberglass-HeLa cells-bacteriophage T4).Sheldon R, Jurale C, Kates J1972 Feb4501121