EC number:2.7.7.60

Enzyme

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     2. Transferases
        2.7 Transferring phosphorus-containing groups
            2.7.7 Nucleotidyltransferases
ID:2.7.7.60
Description:2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase.
Alternative Name: MEP cytidylyltransferase.
MCT.
4-diphosphocytidyl-2-C-methyl-D-erythritol synthase.
Cath: 3.30.1330.50; 3.90.550.10;

3D structure

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PDB

References

External Links

UniProtKB Enzyme Link: UniProtKB 2.7.7.60
BRENDA Enzyme Link: BRENDA 2.7.7.60
KEGG Enzyme Link: KEGG2.7.7.60
BioCyc Enzyme Link: BioCyc 2.7.7.60
ExPASy Enzyme Link: ExPASy2.7.7.60
EC2PDB Enzyme Link: EC2PDB 2.7.7.60
ExplorEnz Enzyme Link: ExplorEnz 2.7.7.60
PRIAM enzyme-specific profiles Link: PRIAM 2.7.7.60
IntEnz Enzyme Link: IntEnz 2.7.7.60
MEDLINE Enzyme Link: MEDLINE 2.7.7.60

EC number:2.7.7.60

MSA:

2.7.7.60;
Phylogenetic Tree:

2.7.7.60;
Uniprot:
M-CSA:
RHEA:13429 2-C-methyl-D-erythritol 4-phosphate + CTP + H(+) = 4-CDP-2-C-methyl-D-erythritol + diphosphate
RULE(radius=1) [*:1]-[OH;+0:2].[*:3]-[P;H0;+0:4](=[*:5])(-[*:6])-[O;H0;+0:7]-[*:8].[H+;H0:9]>>[*:8]-[OH;+0:7].[*:3]-[P;H0;+0:4](=[*:5])(-[*:6])-[O;H0;+0:2]-[*:1]
Reaction
Core-to-Core No scaffolds atoms were exchanged as a result of the reaction

References

TitleAuthorsDatePubMed ID
Biosynthesis of isoprenoids: characterization of a functionally active recombinant 2-C-methyl-D-erythritol 4-phosphate cytidyltransferase (IspD) from Mycobacterium tuberculosis H37Rv.Shi W, Feng J, Zhang M, Lai X, Xu S, Zhang X, Wang H2007 Nov 3018047786
Characterization of the Mycobacterium tuberculosis 4-diphosphocytidyl-2-C-methyl-D-erythritol synthase: potential for drug development.Eoh H, Brown AC, Buetow L, Hunter WN, Parish T, Kaur D, Brennan PJ, Crick DC2007 Dec17921290