EC number:2.7.7.87
Enzyme
Download| EC Tree |
| 2. Transferases |
| 2.7 Transferring phosphorus-containing groups |
| 2.7.7 Nucleotidyltransferases |
| ID: | 2.7.7.87 |
|---|---|
| Description: | L-threonylcarbamoyladenylate synthase. |
| Cath: | 3.90.870.10; 3.40.50.11030; |
3D structure
Click one PDB to see exact 3D structure provided by NGL.
Note: Use your mouse to drag, rotate, and zoom in and out of the structure. Mouse-over to identify atoms and bonds. Mouse controls documentation.References
External Links
| UniProtKB Enzyme Link: | UniProtKB 2.7.7.87 |
| BRENDA Enzyme Link: | BRENDA 2.7.7.87 |
| KEGG Enzyme Link: | KEGG2.7.7.87 |
| BioCyc Enzyme Link: | BioCyc 2.7.7.87 |
| ExPASy Enzyme Link: | ExPASy2.7.7.87 |
| EC2PDB Enzyme Link: | EC2PDB 2.7.7.87 |
| ExplorEnz Enzyme Link: | ExplorEnz 2.7.7.87 |
| PRIAM enzyme-specific profiles Link: | PRIAM 2.7.7.87 |
| IntEnz Enzyme Link: | IntEnz 2.7.7.87 |
| MEDLINE Enzyme Link: | MEDLINE 2.7.7.87 |
| RHEA:36407 | ATP + hydrogencarbonate + L-threonine = diphosphate + H2O + L-threonylcarbamoyladenylate |
| RULE(radius=1) | [*:1]-[NH2;+0:2].[*:3]=[C;H0;+0:4](-[OH;+0:5])-[OH;+0:6].[*:7]=[P;H0;+0:8](-[*:9])(-[*:10])-[O;H0;+0:11]-[*:12]>>[*:12]-[OH;+0:11].[*:7]=[P;H0;+0:8](-[*:9])(-[*:10])-[O;H0;+0:5]-[C;H0;+0:4](=[*:3])-[NH;+0:2]-[*:1].[OH2;+0:6] |
| Reaction |  |
| Core-to-Core | No scaffolds atoms were exchanged as a result of the reaction |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Reconstitution and characterization of eukaryotic N6-threonylcarbamoylation of tRNA using a minimal enzyme system. | Wan LC, Mao DY, Neculai D, Strecker J, Chiovitti D, Kurinov I, Poda G, Thevakumaran N, Yuan F, Szilard RK, Lissina E, Nislow C, Caudy AA, Durocher D, Sicheri F | 2013 Jul | 23620299 |
| In vitro biosynthesis of a universal t6A tRNA modification in Archaea and Eukarya. | Perrochia L, Crozat E, Hecker A, Zhang W, Bareille J, Collinet B, van Tilbeurgh H, Forterre P, Basta T | 2013 Feb 1 | 23258706 |
| Mechanism of N6-threonylcarbamoyladenonsine (t(6)A) biosynthesis: isolation and characterization of the intermediate threonylcarbamoyl-AMP. | Lauhon CT | 2012 Nov 6 | 23072323 |
| YrdC exhibits properties expected of a subunit for a tRNA threonylcarbamoyl transferase. | Harris KA, Jones V, Bilbille Y, Swairjo MA, Agris PF | 2011 Sep | 21775474 |
| Crystal structure of Sulfolobus tokodaii Sua5 complexed with L-threonine and AMPPNP. | Kuratani M, Kasai T, Akasaka R, Higashijima K, Terada T, Kigawa T, Shinkai A, Bessho Y, Yokoyama S | 2011 Jul | 21538543 |
| The universal YrdC/Sua5 family is required for the formation of threonylcarbamoyladenosine in tRNA. | El Yacoubi B, Lyons B, Cruz Y, Reddy R, Nordin B, Agnelli F, Williamson JR, Schimmel P, Swairjo MA, de Crécy-Lagard V | 2009 May | 19287007 |