EC number:2.7.7.n1
| ID: | 2.7.7.n1 |
|---|---|
| Description: | Protein adenylyltransferase. |
| Cath: | 1.10.3290.10; 1.20.120.1520; 1.20.1260.70; 1.20.1280.280; 1.20.1440.370; 3.30.460.110; 1.25.40.10; 2.40.50.140; |
3D structure
Click one PDB to see exact 3D structure provided by NGL.
Note: Use your mouse to drag, rotate, and zoom in and out of the structure. Mouse-over to identify atoms and bonds. Mouse controls documentation.References
| RHEA:54292 | ATP + L-threonyl-[protein] = diphosphate + O(4)-(5'-adenylyl)-L-threonyl-[protein] |
| RULE(radius=1) | [*:1]-[OH;+0:2].[*:3]=[P;H0;+0:4](-[*:5])(-[*:6])-[O;H0;+0:7]-[*:8]>>[*:8]-[OH;+0:7].[*:3]=[P;H0;+0:4](-[*:5])(-[*:6])-[O;H0;+0:2]-[*:1] |
| Reaction |  |
| Core-to-Core | No scaffolds atoms were exchanged as a result of the reaction |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Protein AMPylation by an Evolutionarily Conserved Pseudokinase. | Sreelatha A, Yee SS, Lopez VA, Park BC, Kinch LN, Pilch S, Servage KA, Zhang J, Jiou J, Karasiewicz-Urbańska M, Łobocka M, Grishin NV, Orth K, Kucharczyk R, Pawłowski K, Tomchick DR, Tagliabracci VS | 2018 Oct 18 | 30270044 |
| Kinetic and structural insights into the mechanism of AMPylation by VopS Fic domain. | Luong P, Kinch LN, Brautigam CA, Grishin NV, Tomchick DR, Orth K | 2010 Jun 25 | 20410310 |
| AMPylation of Rho GTPases by Vibrio VopS disrupts effector binding and downstream signaling. | Yarbrough ML, Li Y, Kinch LN, Grishin NV, Ball HL, Orth K | 2009 Jan 9 | 19039103 |
| RHEA:54288 | ATP + L-tyrosyl-[protein] = diphosphate + O(4)-(5'-adenylyl)-L-tyrosyl-[protein] |
| RULE(radius=1) | [*:1]-[OH;+0:2].[*:3]=[P;H0;+0:4](-[*:5])(-[*:6])-[O;H0;+0:7]-[*:8]>>[*:8]-[OH;+0:7].[*:3]=[P;H0;+0:4](-[*:5])(-[*:6])-[O;H0;+0:2]-[*:1] |
| Reaction |  |
| Core-to-Core | |
| Core-to-Core |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Protein AMPylation by an Evolutionarily Conserved Pseudokinase. | Sreelatha A, Yee SS, Lopez VA, Park BC, Kinch LN, Pilch S, Servage KA, Zhang J, Jiou J, Karasiewicz-Urbańska M, Łobocka M, Grishin NV, Orth K, Kucharczyk R, Pawłowski K, Tomchick DR, Tagliabracci VS | 2018 Oct 18 | 30270044 |
| Fic domain-catalyzed adenylylation: insight provided by the structural analysis of the type IV secretion system effector BepA. | Palanivelu DV, Goepfert A, Meury M, Guye P, Dehio C, Schirmer T | 2011 Mar | 21213248 |
| The Legionella effector protein DrrA AMPylates the membrane traffic regulator Rab1b. | Müller MP, Peters H, Blümer J, Blankenfeldt W, Goody RS, Itzen A | 2010 Aug 20 | 20651120 |
| Structural basis of Fic-mediated adenylylation. | Xiao J, Worby CA, Mattoo S, Sankaran B, Dixon JE | 2010 Aug | 20622875 |
| The fic domain: regulation of cell signaling by adenylylation. | Worby CA, Mattoo S, Kruger RP, Corbeil LB, Koller A, Mendez JC, Zekarias B, Lazar C, Dixon JE | 2009 Apr 10 | 19362538 |