EC number:2.7.8.2
Enzyme
Download| EC Tree |
| 2. Transferases |
| 2.7 Transferring phosphorus-containing groups |
| 2.7.8 Transferases for other substituted phosphate groups |
| ID: | 2.7.8.2 | ||
|---|---|---|---|
| Description: | Diacylglycerol cholinephosphotransferase. | ||
| Alternative Name: |
Phosphorylcholine--glyceride transferase. Cholinephosphotransferase. Alkylacylglycerol cholinephosphotransferase. 1-alkyl-2-acetylglycerol cholinephosphotransferase. | ||
| Prosite: | PDOC00321; | ||
| PDB: |
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| Cath: | 1.10.1610.10; 3.40.50.10210; |
3D structure
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External Links
| UniProtKB Enzyme Link: | UniProtKB 2.7.8.2 |
| BRENDA Enzyme Link: | BRENDA 2.7.8.2 |
| KEGG Enzyme Link: | KEGG2.7.8.2 |
| BioCyc Enzyme Link: | BioCyc 2.7.8.2 |
| ExPASy Enzyme Link: | ExPASy2.7.8.2 |
| EC2PDB Enzyme Link: | EC2PDB 2.7.8.2 |
| ExplorEnz Enzyme Link: | ExplorEnz 2.7.8.2 |
| PRIAM enzyme-specific profiles Link: | PRIAM 2.7.8.2 |
| IntEnz Enzyme Link: | IntEnz 2.7.8.2 |
| MEDLINE Enzyme Link: | MEDLINE 2.7.8.2 |
| RHEA:36183 | a 1-O-alkyl-2-acetyl-sn-glycerol + CDP-choline = 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine + CMP + H(+) |
| RULE(radius=1) | [*:1]-[O;H0;+0:2]-[P;H0;+0:3](=[*:4])(-[*:5])-[*:6].[*:7]-[OH;+0:8]>>[*:1]-[OH;+0:2].[*:4]=[P;H0;+0:3](-[*:5])(-[*:6])-[O;H0;+0:8]-[*:7] |
| Reaction |  |
| Core-to-Core | No scaffolds atoms were exchanged as a result of the reaction |
| RHEA:36179 | 1-O-alkyl-2-acyl-sn-glycerol + CDP-choline = 1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine + CMP + H(+) |
| RULE(radius=1) | [*:1]-[O;H0;+0:2]-[P;H0;+0:3](=[*:4])(-[*:5])-[*:6].[*:7]-[OH;+0:8]>>[*:1]-[OH;+0:2].[*:4]=[P;H0;+0:3](-[*:5])(-[*:6])-[O;H0;+0:8]-[*:7] |
| Reaction |  |
| Core-to-Core | No scaffolds atoms were exchanged as a result of the reaction |
| RHEA:32939 | a 1,2-diacyl-sn-glycerol + CDP-choline = a 1,2-diacyl-sn-glycero-3-phosphocholine + CMP + H(+) |
| RULE(radius=1) | [*:1]-[O;H0;+0:2]-[P;H0;+0:3](=[*:4])(-[*:5])-[*:6].[*:7]-[OH;+0:8]>>[*:1]-[OH;+0:2].[*:4]=[P;H0;+0:3](-[*:5])(-[*:6])-[O;H0;+0:8]-[*:7] |
| Reaction |  |
| Core-to-Core | No scaffolds atoms were exchanged as a result of the reaction |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Biosynthesis of 1-alkyl-2-acetyl-sn-glycero-3-phosphocholine (platelet activating factor and a hypotensive lipid) by cholinephosphotransferase in various rat tissues. | Renooij W, Snyder F | 1981 Feb 23 | 6260215 |
| sn-1,2-diacylglycerol choline- and ethanolaminephosphotransferases in Saccharomyces cerevisiae. Mixed micellar analysis of the CPT1 and EPT1 gene products. | Hjelmstad RH, Bell RM | 1991 Mar 5 | 1847919 |
| Cloning and expression of a human choline/ethanolaminephosphotransferase: synthesis of phosphatidylcholine and phosphatidylethanolamine. | Henneberry AL, McMaster CR | 1999 Apr 15 | 10191259 |