EC number:2.7.8.27
Enzyme
Download| EC Tree |
| 2. Transferases |
| 2.7 Transferring phosphorus-containing groups |
| 2.7.8 Transferases for other substituted phosphate groups |
| ID: | 2.7.8.27 |
|---|---|
| Description: | Sphingomyelin synthase. |
| Alternative Name: |
SM synthase. Phosphatidylcholine:ceramide cholinephosphotransferase. |
| Cath: | 1.10.150.50; |
3D structure
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External Links
| UniProtKB Enzyme Link: | UniProtKB 2.7.8.27 |
| BRENDA Enzyme Link: | BRENDA 2.7.8.27 |
| KEGG Enzyme Link: | KEGG2.7.8.27 |
| BioCyc Enzyme Link: | BioCyc 2.7.8.27 |
| ExPASy Enzyme Link: | ExPASy2.7.8.27 |
| EC2PDB Enzyme Link: | EC2PDB 2.7.8.27 |
| ExplorEnz Enzyme Link: | ExplorEnz 2.7.8.27 |
| PRIAM enzyme-specific profiles Link: | PRIAM 2.7.8.27 |
| IntEnz Enzyme Link: | IntEnz 2.7.8.27 |
| MEDLINE Enzyme Link: | MEDLINE 2.7.8.27 |
| RHEA:18765 | a 1,2-diacyl-sn-glycero-3-phosphocholine + an N-acylsphing-4-enine = a 1,2-diacyl-sn-glycerol + sphingomyelin |
| RULE(radius=1) | [*:1]-[O;H0;+0:2]-[P;H0;+0:3](=[*:4])(-[*:5])-[*:6].[*:7]-[OH;+0:8]>>[*:1]-[OH;+0:2].[*:4]=[P;H0;+0:3](-[*:5])(-[*:6])-[O;H0;+0:8]-[*:7] |
| Reaction |  |
| Core-to-Core | No scaffolds atoms were exchanged as a result of the reaction |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Cell-free synthesis and functional characterization of sphingolipid synthases from parasitic trypanosomatid protozoa. | Sevova ES, Goren MA, Schwartz KJ, Hsu FF, Turk J, Fox BG, Bangs JD | 2010 Jul 2 | 20457606 |
| Sphingomyelin synthase SMS2 displays dual activity as ceramide phosphoethanolamine synthase. | Ternes P, Brouwers JF, van den Dikkenberg J, Holthuis JC | 2009 Nov | 19454763 |
| Developmentally regulated sphingolipid synthesis in African trypanosomes. | Sutterwala SS, Hsu FF, Sevova ES, Schwartz KJ, Zhang K, Key P, Turk J, Beverley SM, Bangs JD | 2008 Oct | 18699867 |
| Both sphingomyelin synthases SMS1 and SMS2 are required for sphingomyelin homeostasis and growth in human HeLa cells. | Tafesse FG, Huitema K, Hermansson M, van der Poel S, van den Dikkenberg J, Uphoff A, Somerharju P, Holthuis JC | 2007 Jun 15 | 17449912 |
| The multigenic sphingomyelin synthase family. | Tafesse FG, Ternes P, Holthuis JC | 2006 Oct 6 | 16905542 |
| Expression cloning of a human cDNA restoring sphingomyelin synthesis and cell growth in sphingomyelin synthase-defective lymphoid cells. | Yamaoka S, Miyaji M, Kitano T, Umehara H, Okazaki T | 2004 Apr 30 | 14976195 |
| Identification of a family of animal sphingomyelin synthases. | Huitema K, van den Dikkenberg J, Brouwers JF, Holthuis JC | 2004 Jan 14 | 14685263 |