EC number:2.7.8.43
Enzyme
Download| EC Tree |
| 2. Transferases |
| 2.7 Transferring phosphorus-containing groups |
| 2.7.8 Transferases for other substituted phosphate groups |
| ID: | 2.7.8.43 |
|---|---|
| Description: | Lipid A phosphoethanolamine transferase. |
| Alternative Name: |
Lipid A PEA transferase. |
3D structure
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External Links
| UniProtKB Enzyme Link: | UniProtKB 2.7.8.43 |
| BRENDA Enzyme Link: | BRENDA 2.7.8.43 |
| KEGG Enzyme Link: | KEGG2.7.8.43 |
| BioCyc Enzyme Link: | BioCyc 2.7.8.43 |
| ExPASy Enzyme Link: | ExPASy2.7.8.43 |
| EC2PDB Enzyme Link: | EC2PDB 2.7.8.43 |
| ExplorEnz Enzyme Link: | ExplorEnz 2.7.8.43 |
| PRIAM enzyme-specific profiles Link: | PRIAM 2.7.8.43 |
| IntEnz Enzyme Link: | IntEnz 2.7.8.43 |
| MEDLINE Enzyme Link: | MEDLINE 2.7.8.43 |
| RHEA:46904 | a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + H(+) + lipid A hexaacyl 1-(2-aminoethyl diphosphate) = a 1,2-diacyl-sn-glycerol + lipid A 1,4'-bis(2-aminoethyl diphosphate) |
| RULE(radius=1) | [*:1]-[O;H0;+0:2]-[P;H0;+0:3](=[*:4])(-[*:5])-[*:6].[*:7]-[OH;+0:8].[H+;H0:9]>>[*:7]-[O;H0;+0:8]-[P;H0;+0:3](=[*:4])(-[*:5])-[*:6].[*:1]-[OH;+0:2] |
| Reaction |  |
| Core-to-Core | No scaffolds atoms were exchanged as a result of the reaction |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| The structure of the neisserial lipooligosaccharide phosphoethanolamine transferase A (LptA) required for resistance to polymyxin. | Wanty C, Anandan A, Piek S, Walshe J, Ganguly J, Carlson RW, Stubbs KA, Kahler CM, Vrielink A | 2013 Sep 23 | 23810904 |
| Cloning, expression, purification and crystallization of an endotoxin-biosynthesis enzyme from Neisseria meningitidis. | Anandan A, Piek S, Kahler CM, Vrielink A | 2012 Dec 1 | 23192031 |
| Activation of PmrA inhibits LpxT-dependent phosphorylation of lipid A promoting resistance to antimicrobial peptides. | Herrera CM, Hankins JV, Trent MS | 2010 Jun | 20384697 |
| A link between the assembly of flagella and lipooligosaccharide of the Gram-negative bacterium Campylobacter jejuni. | Cullen TW, Trent MS | 2010 Mar 16 | 20194750 |
| Periplasmic cleavage and modification of the 1-phosphate group of Helicobacter pylori lipid A. | Tran AX, Karbarz MJ, Wang X, Raetz CR, McGrath SC, Cotter RJ, Trent MS | 2004 Dec 31 | 15489235 |
| RHEA:46900 | a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + H(+) + lipid A (E. coli) = a 1,2-diacyl-sn-glycerol + lipid A 4'-(2-aminoethyl diphosphate) (E. coli) |
| RULE(radius=1) | [*:1]-[O;H0;+0:2]-[P;H0;+0:3](=[*:4])(-[*:5])-[*:6].[*:7]-[OH;+0:8].[H+;H0:9]>>[*:7]-[O;H0;+0:8]-[P;H0;+0:3](=[*:4])(-[*:5])-[*:6].[*:1]-[OH;+0:2] |
| Reaction |  |
| Core-to-Core | No scaffolds atoms were exchanged as a result of the reaction |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| The structure of the neisserial lipooligosaccharide phosphoethanolamine transferase A (LptA) required for resistance to polymyxin. | Wanty C, Anandan A, Piek S, Walshe J, Ganguly J, Carlson RW, Stubbs KA, Kahler CM, Vrielink A | 2013 Sep 23 | 23810904 |
| Cloning, expression, purification and crystallization of an endotoxin-biosynthesis enzyme from Neisseria meningitidis. | Anandan A, Piek S, Kahler CM, Vrielink A | 2012 Dec 1 | 23192031 |
| Activation of PmrA inhibits LpxT-dependent phosphorylation of lipid A promoting resistance to antimicrobial peptides. | Herrera CM, Hankins JV, Trent MS | 2010 Jun | 20384697 |
| A link between the assembly of flagella and lipooligosaccharide of the Gram-negative bacterium Campylobacter jejuni. | Cullen TW, Trent MS | 2010 Mar 16 | 20194750 |
| Periplasmic cleavage and modification of the 1-phosphate group of Helicobacter pylori lipid A. | Tran AX, Karbarz MJ, Wang X, Raetz CR, McGrath SC, Cotter RJ, Trent MS | 2004 Dec 31 | 15489235 |
| RHEA:46896 | a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + H(+) + lipid A (E. coli) = a 1,2-diacyl-sn-glycerol + lipid A hexaacyl 1-(2-aminoethyl diphosphate) |
| RULE(radius=1) | [*:1]-[O;H0;+0:2]-[P;H0;+0:3](=[*:4])(-[*:5])-[*:6].[*:7]-[OH;+0:8].[H+;H0:9]>>[*:1]-[OH;+0:2].[*:4]=[P;H0;+0:3](-[*:5])(-[*:6])-[O;H0;+0:8]-[*:7] |
| Reaction |  |
| Core-to-Core | No scaffolds atoms were exchanged as a result of the reaction |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| The structure of the neisserial lipooligosaccharide phosphoethanolamine transferase A (LptA) required for resistance to polymyxin. | Wanty C, Anandan A, Piek S, Walshe J, Ganguly J, Carlson RW, Stubbs KA, Kahler CM, Vrielink A | 2013 Sep 23 | 23810904 |
| Cloning, expression, purification and crystallization of an endotoxin-biosynthesis enzyme from Neisseria meningitidis. | Anandan A, Piek S, Kahler CM, Vrielink A | 2012 Dec 1 | 23192031 |
| Activation of PmrA inhibits LpxT-dependent phosphorylation of lipid A promoting resistance to antimicrobial peptides. | Herrera CM, Hankins JV, Trent MS | 2010 Jun | 20384697 |
| A link between the assembly of flagella and lipooligosaccharide of the Gram-negative bacterium Campylobacter jejuni. | Cullen TW, Trent MS | 2010 Mar 16 | 20194750 |
| Periplasmic cleavage and modification of the 1-phosphate group of Helicobacter pylori lipid A. | Tran AX, Karbarz MJ, Wang X, Raetz CR, McGrath SC, Cotter RJ, Trent MS | 2004 Dec 31 | 15489235 |