EC number:2.7.8.7

Enzyme

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     2. Transferases
        2.7 Transferring phosphorus-containing groups
            2.7.8 Transferases for other substituted phosphate groups
ID:2.7.8.7
Description:Holo-[acyl-carrier-protein] synthase.
Alternative Name: PPTase.
P-pant transferase.
L-aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl
Holosynthase.
Holo-ACP synthetase.
Holo-ACP synthase.
transferase.
Alpha-aminoadipic semialdehyde dehydrogenase-phosphopantetheinyl
Acyl carrier protein synthetase.
Acyl carrier protein synthase.
Acyl carrier protein holoprotein (holo-ACP) synthetase.
ACPS.
4'-phosphopantetheinyl transferase.
Cath: 1.10.110.40; 1.10.1200.10; 1.10.1470.20; 1.10.287.1960; 1.10.287.3140; 1.20.1050.120; 1.20.5.3540; 3.20.20.70; 3.30.1120.10; 3.30.1120.100;

3D structure

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PDB

References

External Links

UniProtKB Enzyme Link: UniProtKB 2.7.8.7
BRENDA Enzyme Link: BRENDA 2.7.8.7
KEGG Enzyme Link: KEGG2.7.8.7
BioCyc Enzyme Link: BioCyc 2.7.8.7
ExPASy Enzyme Link: ExPASy2.7.8.7
EC2PDB Enzyme Link: EC2PDB 2.7.8.7
ExplorEnz Enzyme Link: ExplorEnz 2.7.8.7
PRIAM enzyme-specific profiles Link: PRIAM 2.7.8.7
IntEnz Enzyme Link: IntEnz 2.7.8.7
MEDLINE Enzyme Link: MEDLINE 2.7.8.7

EC number:2.7.8.7

MSA:

2.7.8.7;
Phylogenetic Tree:

2.7.8.7;
Uniprot:
M-CSA:
RHEA:12068 apo-[ACP] + CoA = adenosine 3',5'-bisphosphate + H(+) + holo-[ACP]
RULE(radius=1) [*:1]-[OH;+0:2].[*:3]-[P;H0;+0:4](=[*:5])(-[*:6])-[O;H0;+0:7]-[*:8]>>[*:8]-[OH;+0:7].[*:3]-[P;H0;+0:4](=[*:5])(-[*:6])-[O;H0;+0:2]-[*:1]
Reaction
Core-to-Core No scaffolds atoms were exchanged as a result of the reaction

References

TitleAuthorsDatePubMed ID
Identification of a Mycobacterium tuberculosis gene cluster encoding the biosynthetic enzymes for assembly of the virulence-conferring siderophore mycobactin.Quadri LE, Sello J, Keating TA, Weinreb PH, Walsh CT1998 Nov9831524
Detection of soluble co-factor dependent protein expression in vivo: application to the 4'-phosphopantetheinyl transferase PptT from Mycobacterium tuberculosis.Rottier K, Faille A, Prudhomme T, Leblanc C, Chalut C, Cabantous S, Guilhot C, Mourey L, Pedelacq JD2013 Sep23916562
Cloning, expression, and characterization of a human 4'-phosphopantetheinyl transferase with broad substrate specificity.Joshi AK, Zhang L, Rangan VS, Smith S2003 Aug 2912815048