EC number:2.7.9.6

Enzyme

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     2. Transferases
        2.7 Transferring phosphorus-containing groups
            2.7.9 Phosphotransferases with paired acceptors
ID:2.7.9.6
Description:Rifampicin phosphotransferase.

3D structure

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PDB

References

External Links

UniProtKB Enzyme Link: UniProtKB 2.7.9.6
BRENDA Enzyme Link: BRENDA 2.7.9.6
KEGG Enzyme Link: KEGG2.7.9.6
BioCyc Enzyme Link: BioCyc 2.7.9.6
ExPASy Enzyme Link: ExPASy2.7.9.6
EC2PDB Enzyme Link: EC2PDB 2.7.9.6
ExplorEnz Enzyme Link: ExplorEnz 2.7.9.6
PRIAM enzyme-specific profiles Link: PRIAM 2.7.9.6
IntEnz Enzyme Link: IntEnz 2.7.9.6
MEDLINE Enzyme Link: MEDLINE 2.7.9.6

EC number:2.7.9.6

MSA:

2.7.9.6;
Phylogenetic Tree:

2.7.9.6;
Uniprot:
M-CSA:
RHEA:56304 ATP + H2O + rifampicin = 21-phosphorifampicin + AMP + 2 H(+) + phosphate
RULE(radius=1) [*:1]-[OH;+0:2].[*:3]=[P;H0;+0:4](-[*:5])(-[*:6])-[O;H0;+0:7]-[P;H0;+0:8](=[*:9])(-[*:10])-[O;H0;+0:11]-[*:12].[OH2;+0:13]>>[*:1]-[O;H0;+0:2]-[P;H0;+0:8](=[*:9])(-[*:10])-[OH;+0:7].[*:12]-[OH;+0:11].[*:3]=[P;H0;+0:4](-[*:5])(-[*:6])-[OH;+0:13]
Reaction
Core-to-Core No scaffolds atoms were exchanged as a result of the reaction

References

TitleAuthorsDatePubMed ID
Rifampin phosphotransferase is an unusual antibiotic resistance kinase.Stogios PJ, Cox G, Spanogiannopoulos P, Pillon MC, Waglechner N, Skarina T, Koteva K, Guarné A, Savchenko A, Wright GD2016 Apr 2227103605
A rifamycin inactivating phosphotransferase family shared by environmental and pathogenic bacteria.Spanogiannopoulos P, Waglechner N, Koteva K, Wright GD2014 May 1324778229