EC number:2.8.1.10
Enzyme
Download| EC Tree |
| 2. Transferases |
| 2.8 Transferring sulfur-containing groups |
| 2.8.1 Sulfurtransferases |
| ID: | 2.8.1.10 |
|---|---|
| Description: | Thiazole synthase. |
| Cath: | 3.20.20.70; 3.30.9.10; 3.50.50.60; 3.40.225.10; |
3D structure
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External Links
| UniProtKB Enzyme Link: | UniProtKB 2.8.1.10 |
| BRENDA Enzyme Link: | BRENDA 2.8.1.10 |
| KEGG Enzyme Link: | KEGG2.8.1.10 |
| BioCyc Enzyme Link: | BioCyc 2.8.1.10 |
| ExPASy Enzyme Link: | ExPASy2.8.1.10 |
| EC2PDB Enzyme Link: | EC2PDB 2.8.1.10 |
| ExplorEnz Enzyme Link: | ExplorEnz 2.8.1.10 |
| PRIAM enzyme-specific profiles Link: | PRIAM 2.8.1.10 |
| IntEnz Enzyme Link: | IntEnz 2.8.1.10 |
| MEDLINE Enzyme Link: | MEDLINE 2.8.1.10 |
| RHEA:26297 | 1-deoxy-D-xylulose 5-phosphate + 2-iminoacetate + [sulfur-carrier protein ThiS]-C-terminal Gly-NH-CH2-C(O)SH = 2-[(2R,5Z)-2-carboxy-4-methylthiazol-5(2H)-ylidene]ethyl phosphate + [sulfur-carrier protein ThiS]-C-terminal Gly-Gly + 2 H(+) + 2 H2O |
| RULE(radius=1) | [*:1]-[C;H0;+0:2](=[*:3])-[SH;+0:4].[*:5]-[C;H0;+0:6](=[O;H0;+0:7])-[CH;+0:8](-[OH;+0:9])-[CH;+0:10](-[*:11])-[OH;+0:12].[*:13]=[C;H0;+0:14](-[OH;+0:15])-[CH;+0:16]=[NH;+0:17]>>[*:1]-[C;H0;+0:2](=[*:3])-[OH;+0:12].[*:13]=[C;H0;+0:14](-[OH;+0:9])-[CH;+0:16]1-[N;H0;+0:17]=[C;H0;+0:6](-[*:5])-[C;H0;+0:8](=[CH;+0:10]-[*:11])-[S;H0;+0:4]-1.[OH2;+0:7].[OH2;+0:15] |
| Reaction |  |
| Core-to-Core | No scaffolds atoms were exchanged as a result of the reaction |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| A missing enzyme in thiamin thiazole biosynthesis: identification of TenI as a thiazole tautomerase. | Hazra AB, Han Y, Chatterjee A, Zhang Y, Lai RY, Ealick SE, Begley TP | 2011 Jun 22 | 21534620 |
| Biosynthesis of the thiamin thiazole in Bacillus subtilis: identification of the product of the thiazole synthase-catalyzed reaction. | Hazra A, Chatterjee A, Begley TP | 2009 Mar 11 | 19216519 |
| The biosynthesis of the thiazole phosphate moiety of thiamin: the sulfur transfer mediated by the sulfur carrier protein ThiS. | Dorrestein PC, Zhai H, McLafferty FW, Begley TP | 2004 Oct | 15489164 |
| Thiamin biosynthesis in Bacillus subtilis: structure of the thiazole synthase/sulfur carrier protein complex. | Settembre EC, Dorrestein PC, Zhai H, Chatterjee A, McLafferty FW, Begley TP, Ealick SE | 2004 Sep 21 | 15362849 |
| The biosynthesis of the thiazole phosphate moiety of thiamin (vitamin B1): the early steps catalyzed by thiazole synthase. | Dorrestein PC, Zhai H, Taylor SV, McLafferty FW, Begley TP | 2004 Mar 17 | 15012138 |
| Biosynthesis of the thiazole moiety of thiamin pyrophosphate (vitamin B1). | Park JH, Dorrestein PC, Zhai H, Kinsland C, McLafferty FW, Begley TP | 2003 Oct 28 | 14567704 |