EC number:2.8.1.12
Enzyme
Download| EC Tree |
| 2. Transferases |
| 2.8 Transferring sulfur-containing groups |
| 2.8.1 Sulfurtransferases |
| ID: | 2.8.1.12 |
|---|---|
| Description: | Molybdopterin synthase. |
| Alternative Name: |
MPT synthase. |
| Cath: | 3.90.1170.40; 3.40.250.10; |
3D structure
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External Links
| UniProtKB Enzyme Link: | UniProtKB 2.8.1.12 |
| BRENDA Enzyme Link: | BRENDA 2.8.1.12 |
| KEGG Enzyme Link: | KEGG2.8.1.12 |
| BioCyc Enzyme Link: | BioCyc 2.8.1.12 |
| ExPASy Enzyme Link: | ExPASy2.8.1.12 |
| EC2PDB Enzyme Link: | EC2PDB 2.8.1.12 |
| ExplorEnz Enzyme Link: | ExplorEnz 2.8.1.12 |
| PRIAM enzyme-specific profiles Link: | PRIAM 2.8.1.12 |
| IntEnz Enzyme Link: | IntEnz 2.8.1.12 |
| MEDLINE Enzyme Link: | MEDLINE 2.8.1.12 |
| RHEA:26333 | 2 [molybdopterin-synthase sulfur-carrier protein]-C-terminal Gly-NH-CH2-C(O)SH + cyclic pyranopterin phosphate + H2O = 2 [molybdopterin-synthase sulfur-carrier protein]-C-terminal Gly-Gly + 4 H(+) + molybdopterin |
| RULE(radius=1) | [*:1]-[C;H0;+0:2](=[*:3])-[SH;+0:4].[*:5]-[C;H0;+0:6](=[*:7])-[SH;+0:8].[*:9]-[CH;+0:10](-[O;H0;+0:11]-[*:12])-[C;H0;+0:13](-[*:14])=[O;H0;+0:15].[OH2;+0:16]>>([*:9]-[C;H0;+0:10](-[SH;+0:4])=[C;H0;+0:13](-[*:14])-[SH;+0:8].[*:12]-[OH;+0:11]).[*:5]-[C;H0;+0:6](=[*:7])-[OH;+0:15].[*:1]-[C;H0;+0:2](=[*:3])-[OH;+0:16] |
| Reaction |  |
| Core-to-Core |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Investigation of the early steps of molybdopterin biosynthesis in Escherichia coli through the use of in vivo labeling studies. | Wuebbens MM, Rajagopalan KV | 1995 Jan 20 | 7836363 |
| Crystal structure of a molybdopterin synthase-precursor Z complex: insight into its sulfur transfer mechanism and its role in molybdenum cofactor deficiency. | Daniels JN, Wuebbens MM, Rajagopalan KV, Schindelin H | 2008 Jan 15 | 18092812 |
| Evidence for the physiological role of a rhodanese-like protein for the biosynthesis of the molybdenum cofactor in humans. | Matthies A, Rajagopalan KV, Mendel RR, Leimkühler S | 2004 Apr 20 | 15073332 |
| The tetrahydropyranopterin structure of the sulfur-free and metal-free molybdenum cofactor precursor. | Santamaria-Araujo JA, Fischer B, Otte T, Nimtz M, Mendel RR, Wray V, Schwarz G | 2004 Apr 16 | 14761975 |
| Mechanistic studies of human molybdopterin synthase reaction and characterization of mutants identified in group B patients of molybdenum cofactor deficiency. | Leimkuhler S, Freuer A, Araujo JA, Rajagopalan KV, Mendel RR | 2003 Jul 11 | 12732628 |
| Structural studies of molybdopterin synthase provide insights into its catalytic mechanism. | Rudolph MJ, Wuebbens MM, Turque O, Rajagopalan KV, Schindelin H | 2003 Apr 18 | 12571227 |
| Mechanistic and mutational studies of Escherichia coli molybdopterin synthase clarify the final step of molybdopterin biosynthesis. | Wuebbens MM, Rajagopalan KV | 2003 Apr 18 | 12571226 |
| Crystal structure of molybdopterin synthase and its evolutionary relationship to ubiquitin activation. | Rudolph MJ, Wuebbens MM, Rajagopalan KV, Schindelin H | 2001 Jan | 11135669 |