EC number:2.8.1.15
Enzyme
Download| EC Tree |
| 2. Transferases |
| 2.8 Transferring sulfur-containing groups |
| 2.8.1 Sulfurtransferases |
| ID: | 2.8.1.15 |
|---|---|
| Description: | tRNA-5-methyluridine(54) 2-sulfurtransferase. |
3D structure
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External Links
| UniProtKB Enzyme Link: | UniProtKB 2.8.1.15 |
| BRENDA Enzyme Link: | BRENDA 2.8.1.15 |
| KEGG Enzyme Link: | KEGG2.8.1.15 |
| BioCyc Enzyme Link: | BioCyc 2.8.1.15 |
| ExPASy Enzyme Link: | ExPASy2.8.1.15 |
| EC2PDB Enzyme Link: | EC2PDB 2.8.1.15 |
| ExplorEnz Enzyme Link: | ExplorEnz 2.8.1.15 |
| PRIAM enzyme-specific profiles Link: | PRIAM 2.8.1.15 |
| IntEnz Enzyme Link: | IntEnz 2.8.1.15 |
| MEDLINE Enzyme Link: | MEDLINE 2.8.1.15 |
| RHEA:52720 | 5-methyluridine(54) in tRNA + [TtuB sulfur-carrier protein]-Gly-NH-CH2-C(O)SH + ATP + H2O = 5-methyl-2-thiouridine(54) in tRNA + [TtuB sulfur-carrier protein]-C-terminal Gly-Gly + AMP + diphosphate + 2 H(+) |
| RULE(radius=1) | [*:1]-[C;H0;+0:2](=[*:3])-[SH;+0:4].[*:5]-[O;H0;+0:6]-[P;H0;+0:7](-[*:8])(=[*:9])-[*:10].[*:11]:[c;H0;+0:12](:[*:13])=[O;H0;+0:14].[OH2;+0:15]>>[*:1]-[C;H0;+0:2](=[*:3])-[OH;+0:14].[*:5]-[OH;+0:6].[*:8]-[P;H0;+0:7](=[*:9])(-[*:10])-[OH;+0:15].[*:11]:[c;H0;+0:12](:[*:13])=[S;H0;+0:4] |
| Reaction |  |
| Core-to-Core |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Crystallographic study of the 2-thioribothymidine-synthetic complex TtuA-TtuB from Thermus thermophilus. | Chen M, Narai S, Omura N, Shigi N, Chimnaronk S, Tanaka Y, Yao M | 2016 Oct 1 | 27710943 |
| Crystallographic and mutational studies on the tRNA thiouridine synthetase TtuA. | Nakagawa H, Kuratani M, Goto-Ito S, Ito T, Katsura K, Terada T, Shirouzu M, Sekine S, Shigi N, Yokoyama S | 2013 Jul | 23444054 |
| Identification of two tRNA thiolation genes required for cell growth at extremely high temperatures. | Shigi N, Sakaguchi Y, Suzuki T, Watanabe K | 2006 May 19 | 16547008 |
| Temperature-dependent biosynthesis of 2-thioribothymidine of Thermus thermophilus tRNA. | Shigi N, Suzuki T, Terada T, Shirouzu M, Yokoyama S, Watanabe K | 2006 Jan 27 | 16317006 |