EC number:2.8.2.1
Enzyme
Download| EC Tree |
| 2. Transferases |
| 2.8 Transferring sulfur-containing groups |
| 2.8.2 Sulfotransferases |
| ID: | 2.8.2.1 |
|---|---|
| Description: | Aryl sulfotransferase. |
| Alternative Name: |
Sulfokinase. Phenol sulfotransferase. |
| Cath: | 3.40.50.300; |
3D structure
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External Links
| UniProtKB Enzyme Link: | UniProtKB 2.8.2.1 |
| BRENDA Enzyme Link: | BRENDA 2.8.2.1 |
| KEGG Enzyme Link: | KEGG2.8.2.1 |
| BioCyc Enzyme Link: | BioCyc 2.8.2.1 |
| ExPASy Enzyme Link: | ExPASy2.8.2.1 |
| EC2PDB Enzyme Link: | EC2PDB 2.8.2.1 |
| ExplorEnz Enzyme Link: | ExplorEnz 2.8.2.1 |
| PRIAM enzyme-specific profiles Link: | PRIAM 2.8.2.1 |
| IntEnz Enzyme Link: | IntEnz 2.8.2.1 |
| MEDLINE Enzyme Link: | MEDLINE 2.8.2.1 |
| RHEA:12164 | 3'-phosphoadenylyl sulfate + a phenol = a phenyl sulfate + adenosine 3',5'-bisphosphate + H(+) |
| RULE(radius=1) | [*:1]-[O;H0;+0:2]-[S;H0;+0:3](=[*:4])(=[*:5])-[*:6].[*:7]-[OH;+0:8]>>[*:1]-[OH;+0:2].[*:4]=[S;H0;+0:3](=[*:5])(-[*:6])-[O;H0;+0:8]-[*:7] |
| Reaction |  |
| Core-to-Core | No scaffolds atoms were exchanged as a result of the reaction |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| The structure of human SULT1A1 crystallized with estradiol. An insight into active site plasticity and substrate inhibition with multi-ring substrates. | Gamage NU, Tsvetanov S, Duggleby RG, McManus ME, Martin JL | 2005 Dec 16 | 16221673 |
| The molecular basis for the broad substrate specificity of human sulfotransferase 1A1. | Berger I, Guttman C, Amar D, Zarivach R, Aharoni A | 2011 | 22069470 |
| Directed evolution of sulfotransferases and paraoxonases by ancestral libraries. | Alcolombri U, Elias M, Tawfik DS | 2011 Aug 26 | 21723874 |
| Crystal structures of SULT1A2 and SULT1A1 *3: insights into the substrate inhibition and the role of Tyr149 in SULT1A2. | Lu J, Li H, Zhang J, Li M, Liu MY, An X, Liu MC, Chang W | 2010 May 28 | 20417180 |
| Structure of a human carcinogen-converting enzyme, SULT1A1. Structural and kinetic implications of substrate inhibition. | Gamage NU, Duggleby RG, Barnett AC, Tresillian M, Latham CF, Liyou NE, McManus ME, Martin JL | 2003 Feb 28 | 12471039 |