EC number:2.8.2.14
Enzyme
Download| EC Tree |
| 2. Transferases |
| 2.8 Transferring sulfur-containing groups |
| 2.8.2 Sulfotransferases |
| ID: | 2.8.2.14 |
|---|---|
| Description: | Bile-salt sulfotransferase. |
| Alternative Name: |
Glycolithocholate sulfotransferase. Bile salt:3'phosphoadenosine-5'-phosphosulfate:sulfotransferase. Bile acid:3'-phosphoadenosine-5'-phosphosulfate sulfotransferase. Bile acid sulfotransferase I. BAST I. |
| Cath: | 3.40.50.300; |
3D structure
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External Links
| UniProtKB Enzyme Link: | UniProtKB 2.8.2.14 |
| BRENDA Enzyme Link: | BRENDA 2.8.2.14 |
| KEGG Enzyme Link: | KEGG2.8.2.14 |
| BioCyc Enzyme Link: | BioCyc 2.8.2.14 |
| ExPASy Enzyme Link: | ExPASy2.8.2.14 |
| EC2PDB Enzyme Link: | EC2PDB 2.8.2.14 |
| ExplorEnz Enzyme Link: | ExplorEnz 2.8.2.14 |
| PRIAM enzyme-specific profiles Link: | PRIAM 2.8.2.14 |
| IntEnz Enzyme Link: | IntEnz 2.8.2.14 |
| MEDLINE Enzyme Link: | MEDLINE 2.8.2.14 |
| RHEA:14013 | 3'-phosphoadenylyl sulfate + taurolithocholate = adenosine 3',5'-bisphosphate + H(+) + taurolithocholate sulfate |
| RULE(radius=1) | [*:1]-[O;H0;+0:2]-[S;H0;+0:3](=[*:4])(=[*:5])-[*:6].[*:7]-[OH;+0:8]>>[*:1]-[OH;+0:2].[*:4]=[S;H0;+0:3](=[*:5])(-[*:6])-[O;H0;+0:8]-[*:7] |
| Reaction |  |
| Core-to-Core | No scaffolds atoms were exchanged as a result of the reaction |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Evidence for an ordered reaction mechanism for bile salt: 3'phosphoadenosine-5'-phosphosulfate: sulfotransferase from rhesus monkey liver that catalyzes the sulfation of the hepatotoxin glycolithocholate. | Barnes S, Waldrop R, Crenshaw J, King RJ, Taylor KB | 1986 Nov | 3470420 |
| Bile acid sulfotransferase I from rat liver sulfates bile acids and 3-hydroxy steroids: purification, N-terminal amino acid sequence, and kinetic properties. | Barnes S, Buchina ES, King RJ, McBurnett T, Taylor KB | 1989 Apr | 2754334 |
| The enzymes, regulation, and genetics of bile acid synthesis. | Russell DW | 2003 | 12543708 |
| RHEA:10908 | 3'-phosphoadenylyl sulfate + glycolithocholate = adenosine 3',5'-bisphosphate + H(+) + sulfoglycolithocholate |
| RULE(radius=1) | [*:1]-[O;H0;+0:2]-[S;H0;+0:3](=[*:4])(=[*:5])-[*:6].[*:7]-[OH;+0:8]>>[*:1]-[OH;+0:2].[*:4]=[S;H0;+0:3](=[*:5])(-[*:6])-[O;H0;+0:8]-[*:7] |
| Reaction |  |
| Core-to-Core | No scaffolds atoms were exchanged as a result of the reaction |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Evidence for an ordered reaction mechanism for bile salt: 3'phosphoadenosine-5'-phosphosulfate: sulfotransferase from rhesus monkey liver that catalyzes the sulfation of the hepatotoxin glycolithocholate. | Barnes S, Waldrop R, Crenshaw J, King RJ, Taylor KB | 1986 Nov | 3470420 |
| Bile acid sulfotransferase I from rat liver sulfates bile acids and 3-hydroxy steroids: purification, N-terminal amino acid sequence, and kinetic properties. | Barnes S, Buchina ES, King RJ, McBurnett T, Taylor KB | 1989 Apr | 2754334 |
| The enzymes, regulation, and genetics of bile acid synthesis. | Russell DW | 2003 | 12543708 |