EC number:2.8.2.18
Enzyme
Download| EC Tree |
| 2. Transferases |
| 2.8 Transferring sulfur-containing groups |
| 2.8.2 Sulfotransferases |
| ID: | 2.8.2.18 |
|---|---|
| Description: | Cortisol sulfotransferase. |
| Alternative Name: |
Glucocorticosteroid sulfotransferase. |
3D structure
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External Links
| UniProtKB Enzyme Link: | UniProtKB 2.8.2.18 |
| BRENDA Enzyme Link: | BRENDA 2.8.2.18 |
| KEGG Enzyme Link: | KEGG2.8.2.18 |
| BioCyc Enzyme Link: | BioCyc 2.8.2.18 |
| ExPASy Enzyme Link: | ExPASy2.8.2.18 |
| EC2PDB Enzyme Link: | EC2PDB 2.8.2.18 |
| ExplorEnz Enzyme Link: | ExplorEnz 2.8.2.18 |
| PRIAM enzyme-specific profiles Link: | PRIAM 2.8.2.18 |
| IntEnz Enzyme Link: | IntEnz 2.8.2.18 |
| MEDLINE Enzyme Link: | MEDLINE 2.8.2.18 |
| RHEA:11884 | 3'-phosphoadenylyl sulfate + cortisol = adenosine 3',5'-bisphosphate + cortisol 21-sulfate + H(+) |
| RULE(radius=1) | [*:1]-[O;H0;+0:2]-[S;H0;+0:3](=[*:4])(=[*:5])-[*:6].[*:7]-[OH;+0:8]>>[*:1]-[OH;+0:2].[*:4]=[S;H0;+0:3](=[*:5])(-[*:6])-[O;H0;+0:8]-[*:7] |
| Reaction |  |
| Core-to-Core | No scaffolds atoms were exchanged as a result of the reaction |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Enzymatic sulfation of steroids. XVII. The properties of the glucocorticoid sulfotransferase activity of guinea pig liver cytosol. | Singer SS, Brill B | 1982 Sep 14 | 6957246 |
| Enzymatic sulfation of steroids: I. The enzymatic basis for the sex difference in cortisol sulfation by rat liver preparations. | Singer SS, Giera D, Johnson J, Sylvester S | 1976 Apr | 1278101 |