EC number:2.8.2.23
Enzyme
Download| EC Tree |
| 2. Transferases |
| 2.8 Transferring sulfur-containing groups |
| 2.8.2 Sulfotransferases |
| ID: | 2.8.2.23 |
|---|---|
| Description: | [Heparan sulfate]-glucosamine 3-sulfotransferase 1. |
| Alternative Name: |
Heparin-glucosamine 3-O-sulfotransferase. Heparan sulfate D-glucosaminyl 3-O-sulfotransferase. Glucosaminyl 3-O-sulfotransferase. 3-OST-1. 3'-phosphoadenylyl-sulfate:heparin-glucosamine 3-O-sulfotransferase. |
| Cath: | 3.40.50.300; |
3D structure
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External Links
| UniProtKB Enzyme Link: | UniProtKB 2.8.2.23 |
| BRENDA Enzyme Link: | BRENDA 2.8.2.23 |
| KEGG Enzyme Link: | KEGG2.8.2.23 |
| BioCyc Enzyme Link: | BioCyc 2.8.2.23 |
| ExPASy Enzyme Link: | ExPASy2.8.2.23 |
| EC2PDB Enzyme Link: | EC2PDB 2.8.2.23 |
| ExplorEnz Enzyme Link: | ExplorEnz 2.8.2.23 |
| PRIAM enzyme-specific profiles Link: | PRIAM 2.8.2.23 |
| IntEnz Enzyme Link: | IntEnz 2.8.2.23 |
| MEDLINE Enzyme Link: | MEDLINE 2.8.2.23 |
| RHEA:15461 | 3'-phosphoadenylyl sulfate + alpha-D-glucosaminyl-[heparan sulfate](n) = 3-sulfo-alpha-D-glucosaminyl-[heparan sulfate](n) + adenosine 3',5'-bisphosphate + H(+) |
| RULE(radius=1) | [*:1]-[O;H0;+0:2]-[S;H0;+0:3](=[*:4])(=[*:5])-[*:6].[*:7]-[OH;+0:8]>>[*:1]-[OH;+0:2].[*:4]=[S;H0;+0:3](=[*:5])(-[*:6])-[O;H0;+0:8]-[*:7] |
| Reaction |  |
| Core-to-Core | No scaffolds atoms were exchanged as a result of the reaction |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Expression of heparan sulfate D-glucosaminyl 3-O-sulfotransferase isoforms reveals novel substrate specificities. | Liu J, Shworak NW, Sinaÿ P, Schwartz JJ, Zhang L, Fritze LM, Rosenberg RD | 1999 Feb 19 | 9988768 |
| Multiple isoforms of heparan sulfate D-glucosaminyl 3-O-sulfotransferase. Isolation, characterization, and expression of human cdnas and identification of distinct genomic loci. | Shworak NW, Liu J, Petros LM, Zhang L, Kobayashi M, Copeland NG, Jenkins NA, Rosenberg RD | 1999 Feb 19 | 9988767 |