EC number:2.8.2.35
Enzyme
Download| EC Tree |
| 2. Transferases |
| 2.8 Transferring sulfur-containing groups |
| 2.8.2 Sulfotransferases |
| ID: | 2.8.2.35 |
|---|---|
| Description: | Dermatan 4-sulfotransferase. |
| Alternative Name: |
Dermatan-specific N-acetylgalactosamine 4-O-sulfotransferase. Dermatan N-acetylgalactosamine 4-O-sulfotransferase. CHST14 protein. |
3D structure
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External Links
| UniProtKB Enzyme Link: | UniProtKB 2.8.2.35 |
| BRENDA Enzyme Link: | BRENDA 2.8.2.35 |
| KEGG Enzyme Link: | KEGG2.8.2.35 |
| BioCyc Enzyme Link: | BioCyc 2.8.2.35 |
| ExPASy Enzyme Link: | ExPASy2.8.2.35 |
| EC2PDB Enzyme Link: | EC2PDB 2.8.2.35 |
| ExplorEnz Enzyme Link: | ExplorEnz 2.8.2.35 |
| PRIAM enzyme-specific profiles Link: | PRIAM 2.8.2.35 |
| IntEnz Enzyme Link: | IntEnz 2.8.2.35 |
| MEDLINE Enzyme Link: | MEDLINE 2.8.2.35 |
| RHEA:48052 | n 3'-phosphoadenylyl sulfate + dermatan = n adenosine 3',5'-bisphosphate + dermatan 4'-sulfate + n H(+) |
| RULE(radius=1) | [*:1]-[O;H0;+0:2]-[S;H0;+0:3](=[*:4])(=[*:5])-[*:6].[*:7]-[OH;+0:8]>>[*:1]-[OH;+0:2].[*:4]=[S;H0;+0:3](=[*:5])(-[*:6])-[O;H0;+0:8]-[*:7] |
| Reaction |  |
| Core-to-Core | No scaffolds atoms were exchanged as a result of the reaction |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Dermatan 4-O-sulfotransferase 1 is pivotal in the formation of iduronic acid blocks in dermatan sulfate. | Pacheco B, Maccarana M, Malmström A | 2009 Nov | 19661164 |
| Chondroitin sulfate/dermatan sulfate hybrid chains in the development of cerebellum. Spatiotemporal regulation of the expression of critical disulfated disaccharides by specific sulfotransferases. | Mitsunaga C, Mikami T, Mizumoto S, Fukuda J, Sugahara K | 2006 Jul 14 | 16702220 |
| Specificities of three distinct human chondroitin/dermatan N-acetylgalactosamine 4-O-sulfotransferases demonstrated using partially desulfated dermatan sulfate as an acceptor: implication of differential roles in dermatan sulfate biosynthesis. | Mikami T, Mizumoto S, Kago N, Kitagawa H, Sugahara K | 2003 Sep 19 | 12847091 |
| Molecular cloning and characterization of a dermatan-specific N-acetylgalactosamine 4-O-sulfotransferase. | Evers MR, Xia G, Kang HG, Schachner M, Baenziger JU | 2001 Sep 28 | 11470797 |