EC number:2.8.2.4
Enzyme
Download| EC Tree |
| 2. Transferases |
| 2.8 Transferring sulfur-containing groups |
| 2.8.2 Sulfotransferases |
| ID: | 2.8.2.4 |
|---|---|
| Description: | Estrone sulfotransferase. |
| Cath: | 3.40.50.300; |
3D structure
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External Links
| UniProtKB Enzyme Link: | UniProtKB 2.8.2.4 |
| BRENDA Enzyme Link: | BRENDA 2.8.2.4 |
| KEGG Enzyme Link: | KEGG2.8.2.4 |
| BioCyc Enzyme Link: | BioCyc 2.8.2.4 |
| ExPASy Enzyme Link: | ExPASy2.8.2.4 |
| EC2PDB Enzyme Link: | EC2PDB 2.8.2.4 |
| ExplorEnz Enzyme Link: | ExplorEnz 2.8.2.4 |
| PRIAM enzyme-specific profiles Link: | PRIAM 2.8.2.4 |
| IntEnz Enzyme Link: | IntEnz 2.8.2.4 |
| MEDLINE Enzyme Link: | MEDLINE 2.8.2.4 |
| RHEA:15973 | 3'-phosphoadenylyl sulfate + estrone = adenosine 3',5'-bisphosphate + estrone 3-sulfate + H(+) |
| RULE(radius=1) | [*:1]-[O;H0;+0:2]-[S;H0;+0:3](=[*:4])(=[*:5])-[*:6].[*:7]-[OH;+0:8]>>[*:1]-[OH;+0:2].[*:4]=[S;H0;+0:3](=[*:5])(-[*:6])-[O;H0;+0:8]-[*:7] |
| Reaction |  |
| Core-to-Core | No scaffolds atoms were exchanged as a result of the reaction |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| The sulfuryl transfer mechanism. Crystal structure of a vanadate complex of estrogen sulfotransferase and mutational analysis. | Kakuta Y, Petrotchenko EV, Pedersen LC, Negishi M | 1998 Oct 16 | 9765259 |
| Bacterial expression and characterization of a cDNA for human liver estrogen sulfotransferase. | Falany CN, Krasnykh V, Falany JL | 1995 Jun | 7779757 |
| Structural and chemical profiling of the human cytosolic sulfotransferases. | Allali-Hassani A, Pan PW, Dombrovski L, Najmanovich R, Tempel W, Dong A, Loppnau P, Martin F, Thornton J, Edwards AM, Bochkarev A, Plotnikov AN, Vedadi M, Arrowsmith CH | 2007 May | 17425406 |
| Transition state of the sulfuryl transfer reaction of estrogen sulfotransferase. | Hoff RH, Czyryca PG, Sun M, Leyh TS, Hengge AC | 2006 Oct 13 | 16899461 |
| Crystal structure of the human estrogen sulfotransferase-PAPS complex: evidence for catalytic role of Ser137 in the sulfuryl transfer reaction. | Pedersen LC, Petrotchenko E, Shevtsov S, Negishi M | 2002 May 17 | 11884392 |