EC number:2.8.3.5
Enzyme
Download| EC Tree |
| 2. Transferases |
| 2.8 Transferring sulfur-containing groups |
| 2.8.3 CoA-transferases |
3D structure
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External Links
| UniProtKB Enzyme Link: | UniProtKB 2.8.3.5 |
| BRENDA Enzyme Link: | BRENDA 2.8.3.5 |
| KEGG Enzyme Link: | KEGG2.8.3.5 |
| BioCyc Enzyme Link: | BioCyc 2.8.3.5 |
| ExPASy Enzyme Link: | ExPASy2.8.3.5 |
| EC2PDB Enzyme Link: | EC2PDB 2.8.3.5 |
| ExplorEnz Enzyme Link: | ExplorEnz 2.8.3.5 |
| PRIAM enzyme-specific profiles Link: | PRIAM 2.8.3.5 |
| IntEnz Enzyme Link: | IntEnz 2.8.3.5 |
| MEDLINE Enzyme Link: | MEDLINE 2.8.3.5 |
| RHEA:25480 | acetoacetate + succinyl-CoA = acetoacetyl-CoA + succinate |
| RULE(radius=1) | [C:1][S:2][C:3](=[O:4])[C:5].[O:10][C:11](=[O:12])[C:13]>>[O:10][C:3](=[O:4])[C:5].[C:1][S:2][C:11](=[O:12])[C:13] |
| Reaction |  |
| Core-to-Core | No scaffolds atoms were exchanged as a result of the reaction |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Cloning and characterization of Helicobacter pylori succinyl CoA:acetoacetate CoA-transferase, a novel prokaryotic member of the CoA-transferase family. | Corthésy-Theulaz IE, Bergonzelli GE, Henry H, Bachmann D, Schorderet DF, Blum AL, Ornston LN | 1997 Oct 10 | 9325289 |
| Identification of glutamate 344 as the catalytic residue in the active site of pig heart CoA transferase. | Rochet JC, Bridger WA | 1994 Jun | 7915164 |
| Purification and properties of succinyl-CoA:3-oxo-acid CoA-transferase from rat brain. | Russell JJ, Patel MS | 1982 May | 6950030 |
| Initial-velocity kinetics of succinoyl-coenzyme A-3-oxo acid coenzyme A-transferase from sheep kidney. | Sharp JA, Edwards MR | 1983 Jul 1 | 6577858 |
| Catalytic role of the conformational change in succinyl-CoA:3-oxoacid CoA transferase on binding CoA. | Fraser ME, Hayakawa K, Brown WD | 2010 Dec 7 | 20977214 |
| Identification of the cysteine residue exposed by the conformational change in pig heart succinyl-CoA:3-ketoacid coenzyme A transferase on binding coenzyme A. | Tammam SD, Rochet JC, Fraser ME | 2007 Sep 25 | 17718512 |
| Structure of the mammalian CoA transferase from pig heart. | Bateman KS, Brownie ER, Wolodko WT, Fraser ME | 2002 Dec 10 | 12463743 |
| Dimeric pig heart succinate-coenzyme A transferase uses only one subunit to support catalysis. | Lloyd AJ, Shoolingin-Jordan PM | 2001 Feb 27 | 11327867 |
| Pig heart CoA transferase exists as two oligomeric forms separated by a large kinetic barrier. | Rochet JC, Brownie ER, Oikawa K, Hicks LD, Fraser ME, James MN, Kay CM, Bridger WA, Wolodko WT | 2000 Sep 19 | 10985774 |
| RHEA:24564 | a 3-oxo acid + succinyl-CoA = a 3-oxoacyl-CoA + succinate |
| RULE(radius=1) | [C:1][S:2][C:3](=[O:4])[C:5].[O:10][C:11](=[O:12])[C:13]>>[O:10][C:3](=[O:4])[C:5].[C:1][S:2][C:11](=[O:12])[C:13] |
| Reaction |  |
| Core-to-Core | No scaffolds atoms were exchanged as a result of the reaction |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Cloning and characterization of Helicobacter pylori succinyl CoA:acetoacetate CoA-transferase, a novel prokaryotic member of the CoA-transferase family. | Corthésy-Theulaz IE, Bergonzelli GE, Henry H, Bachmann D, Schorderet DF, Blum AL, Ornston LN | 1997 Oct 10 | 9325289 |
| Structure of succinyl-CoA:3-ketoacid CoA transferase from Drosophila melanogaster. | Zhang M, Xu HY, Wang YC, Shi ZB, Zhang NN | 2013 Oct | 24100554 |
| Catalytic role of the conformational change in succinyl-CoA:3-oxoacid CoA transferase on binding CoA. | Fraser ME, Hayakawa K, Brown WD | 2010 Dec 7 | 20977214 |
| Identification of the cysteine residue exposed by the conformational change in pig heart succinyl-CoA:3-ketoacid coenzyme A transferase on binding coenzyme A. | Tammam SD, Rochet JC, Fraser ME | 2007 Sep 25 | 17718512 |
| Enzymic synthesis and metabolism of malonyl coenzyme A and glutaryl coenzyme A. | MENON GK, STERN JR | 1960 Dec | 13769479 |
| Enzymes of fatty acid metabolism. IV. Preparation and properties of coenzyme A transferase. | STERN JR, COON MJ, DEL CAMPILLO A, SCHNEIDER MC | 1956 Jul | 13345795 |
| Enzymes of fatty acid metabolism. | LYNEN F, OCHOA S | 1953 Sep-Oct | 13115439 |