EC number:2.9.1.2

Enzyme

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     2. Transferases
        2.9 Transferring selenium-containing groups
            2.9.1 Selenotransferases
ID:2.9.1.2
Description:O-phospho-L-seryl-tRNA(Sec):L-selenocysteinyl-tRNA synthase.
Alternative Name: SepSecS.
O-phosphoseryl-tRNA:selenocysteinyl-tRNA synthase.
O-phosphoseryl-tRNA(Sec) selenium transferase.
Cath: 1.10.10.2160; 1.10.12.40; 3.40.640.10; 3.90.1150.10; 3.40.50.300;

3D structure

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PDB

References

External Links

UniProtKB Enzyme Link: UniProtKB 2.9.1.2
BRENDA Enzyme Link: BRENDA 2.9.1.2
KEGG Enzyme Link: KEGG2.9.1.2
BioCyc Enzyme Link: BioCyc 2.9.1.2
ExPASy Enzyme Link: ExPASy2.9.1.2
EC2PDB Enzyme Link: EC2PDB 2.9.1.2
ExplorEnz Enzyme Link: ExplorEnz 2.9.1.2
PRIAM enzyme-specific profiles Link: PRIAM 2.9.1.2
IntEnz Enzyme Link: IntEnz 2.9.1.2
MEDLINE Enzyme Link: MEDLINE 2.9.1.2

EC number:2.9.1.2

MSA:

2.9.1.2;
Phylogenetic Tree:

2.9.1.2;
Uniprot:
M-CSA:
RHEA:25041 H2O + O-phospho-L-seryl-tRNA(Sec) + selenophosphate = L-selenocysteinyl-tRNA(Sec) + 2 phosphate
RULE(radius=1) [*:1]-[CH2;+0:2]-[O;H0;+0:3]-[*:4].[*:5]-[P;H0;+0:6](-[*:7])(-[OH;+0:8])=[Se;H0;+0:9].[OH2;+0:10]>>[*:1]-[CH2;+0:2]-[SeH;+0:9].[*:4]-[OH;+0:3].[*:5]-[P;H0;+0:6](-[*:7])(=[O;H0;+0:8])-[OH;+0:10]
Reaction
Core-to-Core No scaffolds atoms were exchanged as a result of the reaction

References

TitleAuthorsDatePubMed ID
The human SepSecS-tRNASec complex reveals the mechanism of selenocysteine formation.Palioura S, Sherrer RL, Steitz TA, Söll D, Simonovic M2009 Jul 1719608919
RNA-dependent conversion of phosphoserine forms selenocysteine in eukaryotes and archaea.Yuan J, Palioura S, Salazar JC, Su D, O'Donoghue P, Hohn MJ, Cardoso AM, Whitman WB, Söll D2006 Dec 1217142313