Enzyme

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     3. Hydrolases
        3.1 Acting on ester bonds
            3.1.1 Carboxylic-ester hydrolases
ID:3.1.1.101
Description:Poly(ethylene terephthalate) hydrolase.
Alternative Name: PETase.
PET hydrolase.

3D structure

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References

External Links

UniProtKB Enzyme Link: UniProtKB 3.1.1.101
BRENDA Enzyme Link: BRENDA 3.1.1.101
KEGG Enzyme Link: KEGG3.1.1.101
BioCyc Enzyme Link: BioCyc 3.1.1.101
ExPASy Enzyme Link: ExPASy3.1.1.101
EC2PDB Enzyme Link: EC2PDB 3.1.1.101
ExplorEnz Enzyme Link: ExplorEnz 3.1.1.101
PRIAM enzyme-specific profiles Link: PRIAM 3.1.1.101
IntEnz Enzyme Link: IntEnz 3.1.1.101
MEDLINE Enzyme Link: MEDLINE 3.1.1.101
MSA:

3.1.1.101;

Phylogenetic Tree:

3.1.1.101;

Uniprot:
M-CSA:
RHEA:49528 (ethylene terephthalate)(n) + H2O = (ethylene terephthalate)(n-1) + 4-[(2-hydroxyethoxy)carbonyl]benzoate + H(+)
RULE(radius=1) [*:1]-[O;H0;+0:2]-[C;H0;+0:3](=[*:4])-[*:5].[OH2;+0:6]>>[*:1]-[OH;+0:2].[*:4]=[C;H0;+0:3](-[*:5])-[OH;+0:6]
Reaction
Core-to-Core More

References

TitleAuthorsDatePubMed ID
Protein Crystallography and Site-Direct Mutagenesis Analysis of the Poly(ethylene terephthalate) Hydrolase PETase from Ideonella sakaiensis.Liu B, He L, Wang L, Li T, Li C, Liu H, Luo Y, Bao R2018 Mar 3029603535
Structural insight into molecular mechanism of poly(ethylene terephthalate) degradation.Joo S, Cho IJ, Seo H, Son HF, Sagong HY, Shin TJ, Choi SY, Lee SY, Kim KJ2018 Jan 2629374183
Structural insight into catalytic mechanism of PET hydrolase.Han X, Liu W, Huang JW, Ma J, Zheng Y, Ko TP, Xu L, Cheng YS, Chen CC, Guo RT2017 Dec 1329235460
Characterization and engineering of a plastic-degrading aromatic polyesterase.Austin HP, Allen MD, Donohoe BS, Rorrer NA, Kearns FL, Silveira RL, Pollard BC, Dominick G, Duman R, El Omari K, Mykhaylyk V, Wagner A, Michener WE, Amore A, Skaf MS, Crowley MF, Thorne AW, Johnson CW, Woodcock HL, McGeehan JE, Beckham GT2018 May 829666242
A bacterium that degrades and assimilates poly(ethylene terephthalate).Yoshida S, Hiraga K, Takehana T, Taniguchi I, Yamaji H, Maeda Y, Toyohara K, Miyamoto K, Kimura Y, Oda K2016 Mar 1126965627