Enzyme

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EC Tree
     3. Hydrolases
        3.1 Acting on ester bonds
            3.1.1 Carboxylic-ester hydrolases
ID:3.1.1.17
Description:Gluconolactonase.
Alternative Name: Lactonase.
Aldonolactonase.
Cath: 2.120.10.30; 3.40.50.1360;

3D structure

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References

External Links

UniProtKB Enzyme Link: UniProtKB 3.1.1.17
BRENDA Enzyme Link: BRENDA 3.1.1.17
KEGG Enzyme Link: KEGG3.1.1.17
BioCyc Enzyme Link: BioCyc 3.1.1.17
ExPASy Enzyme Link: ExPASy3.1.1.17
EC2PDB Enzyme Link: EC2PDB 3.1.1.17
ExplorEnz Enzyme Link: ExplorEnz 3.1.1.17
PRIAM enzyme-specific profiles Link: PRIAM 3.1.1.17
IntEnz Enzyme Link: IntEnz 3.1.1.17
MEDLINE Enzyme Link: MEDLINE 3.1.1.17
MSA:

3.1.1.17;

Phylogenetic Tree:

3.1.1.17;

Uniprot:
M-CSA:
RHEA:10440 D-glucono-1,5-lactone + H2O = D-gluconate + H(+)
RULE(radius=1) [*:1]-[C;H0;+0:2](=[*:3])-[O;H0;+0:4]-[*:5].[OH2;+0:6]>>([*:1]-[C;H0;+0:2](=[*:3])-[OH;+0:6].[*:5]-[OH;+0:4])
Reaction
Core-to-Core No scaffolds atoms were exchanged as a result of the reaction

References

TitleAuthorsDatePubMed ID
A novel carbohydrate:acceptor oxidoreductase from Microdochium nivale.Xu F, Golightly EJ, Fuglsang CC, Schneider P, Duke KR, Lam L, Christensen S, Brown KM, Jørgensen CT, Brown SH2001 Feb11179980
Structural basis of the γ-lactone-ring formation in ascorbic acid biosynthesis by the senescence marker protein-30/gluconolactonase.Aizawa S, Senda M, Harada A, Maruyama N, Ishida T, Aigaki T, Ishigami A, Senda T201323349732
Crystal structure of human senescence marker protein 30: insights linking structural, enzymatic, and physiological functions .Chakraborti S, Bahnson BJ2010 Apr 2720329768
Senescence marker protein 30 functions as gluconolactonase in L-ascorbic acid biosynthesis, and its knockout mice are prone to scurvy.Kondo Y, Inai Y, Sato Y, Handa S, Kubo S, Shimokado K, Goto S, Nishikimi M, Maruyama N, Ishigami A2006 Apr 1116585534
Coimmobilization of gluconolactonase with glucose oxidase for improvement in kinetic property of enzymatically induced volume collapse in ionic gels.Ogawa K, Nakajima-Kambe T, Nakahara T, Kokufuta E2002 May-Jun12005536