EC number:3.1.1.2
| ID: | 3.1.1.2 |
|---|---|
| Description: | Arylesterase. |
| Alternative Name: |
Paraoxonase. A-esterase. |
| Cath: | 3.20.20.140; 3.40.710.10; 3.60.15.10; 3.90.230.10; 2.120.10.30; 2.40.128.130; 3.40.350.10; 3.40.50.1110; 3.40.50.1820; |
3D structure
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External Links
| UniProtKB Enzyme Link: | UniProtKB 3.1.1.2 |
| BRENDA Enzyme Link: | BRENDA 3.1.1.2 |
| KEGG Enzyme Link: | KEGG3.1.1.2 |
| BioCyc Enzyme Link: | BioCyc 3.1.1.2 |
| ExPASy Enzyme Link: | ExPASy3.1.1.2 |
| EC2PDB Enzyme Link: | EC2PDB 3.1.1.2 |
| ExplorEnz Enzyme Link: | ExplorEnz 3.1.1.2 |
| PRIAM enzyme-specific profiles Link: | PRIAM 3.1.1.2 |
| IntEnz Enzyme Link: | IntEnz 3.1.1.2 |
| MEDLINE Enzyme Link: | MEDLINE 3.1.1.2 |
| RHEA:17309 | a phenyl acetate + H2O = a phenol + acetate + H(+) |
| RULE(radius=1) | [*:1]-[C;H0;+0:2](=[*:3])-[O;H0;+0:4]-[*:5].[OH2;+0:6]>>[*:1]-[C;H0;+0:2](=[*:3])-[OH;+0:6].[*:5]-[OH;+0:4] |
| Reaction |  |
| Core-to-Core | No scaffolds atoms were exchanged as a result of the reaction |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Distinction between 'A'-esterases and arylesterases. Implications for esterase classification. | Mackness MI, Thompson HM, Hardy AR, Walker CH | 1987 Jul 1 | 2822017 |
| Nonserine esterases from rat liver cytosol. | Kim DH, Yang YS, Jakoby WB | 1990 Sep | 2152179 |
| Purification of rabbit and human serum paraoxonase. | Furlong CE, Richter RJ, Chapline C, Crabb JW | 1991 Oct 22 | 1718413 |
| Quorum quenching enzyme activity is widely conserved in the sera of mammalian species. | Yang F, Wang LH, Wang J, Dong YH, Hu JY, Zhang LH | 2005 Jul 4 | 15963993 |
| Structure-reactivity studies of serum paraoxonase PON1 suggest that its native activity is lactonase. | Khersonsky O, Tawfik DS | 2005 Apr 26 | 15835926 |
| Human paraoxonases (PON1, PON2, and PON3) are lactonases with overlapping and distinct substrate specificities. | Draganov DI, Teiber JF, Speelman A, Osawa Y, Sunahara R, La Du BN | 2005 Jun | 15772423 |
| Structure of an aryl esterase from Pseudomonas fluorescens. | Cheeseman JD, Tocilj A, Park S, Schrag JD, Kazlauskas RJ | 2004 Jul | 15213385 |
| Structure and evolution of the serum paraoxonase family of detoxifying and anti-atherosclerotic enzymes. | Harel M, Aharoni A, Gaidukov L, Brumshtein B, Khersonsky O, Meged R, Dvir H, Ravelli RB, McCarthy A, Toker L, Silman I, Sussman JL, Tawfik DS | 2004 May | 15098021 |