EC number:3.1.1.25
| ID: | 3.1.1.25 |
|---|---|
| Description: | 1,4-lactonase. |
| Alternative Name: |
Gamma-lactonase. |
3D structure
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External Links
| UniProtKB Enzyme Link: | UniProtKB 3.1.1.25 |
| BRENDA Enzyme Link: | BRENDA 3.1.1.25 |
| KEGG Enzyme Link: | KEGG3.1.1.25 |
| BioCyc Enzyme Link: | BioCyc 3.1.1.25 |
| ExPASy Enzyme Link: | ExPASy3.1.1.25 |
| EC2PDB Enzyme Link: | EC2PDB 3.1.1.25 |
| ExplorEnz Enzyme Link: | ExplorEnz 3.1.1.25 |
| PRIAM enzyme-specific profiles Link: | PRIAM 3.1.1.25 |
| IntEnz Enzyme Link: | IntEnz 3.1.1.25 |
| MEDLINE Enzyme Link: | MEDLINE 3.1.1.25 |
| RHEA:52648 | H2O + L-arabino-1,4-lactone-5-phosphate = 5-phospho-L-arabinonate + H(+) |
| RULE(radius=1) | [*:1]-[C;H0;+0:2](=[*:3])-[O;H0;+0:4]-[*:5].[OH2;+0:6]>>([*:1]-[C;H0;+0:2](=[*:3])-[OH;+0:6].[*:5]-[OH;+0:4]) |
| Reaction |  |
| Core-to-Core | No scaffolds atoms were exchanged as a result of the reaction |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Functional annotation and structural characterization of a novel lactonase hydrolyzing D-xylono-1,4-lactone-5-phosphate and L-arabino-1,4-lactone-5-phosphate. | Korczynska M, Xiang DF, Zhang Z, Xu C, Narindoshvili T, Kamat SS, Williams HJ, Chang SS, Kolb P, Hillerich B, Sauder JM, Burley SK, Almo SC, Swaminathan S, Shoichet BK, Raushel FM | 2014 Jul 22 | 24955762 |
| RHEA:52644 | D-xylono-1,4-lactone-5-phosphate + H2O = 5-phospho-D-xylonate + H(+) |
| RULE(radius=1) | [*:1]-[C;H0;+0:2](=[*:3])-[O;H0;+0:4]-[*:5].[OH2;+0:6]>>([*:1]-[C;H0;+0:2](=[*:3])-[OH;+0:6].[*:5]-[OH;+0:4]) |
| Reaction |  |
| Core-to-Core | No scaffolds atoms were exchanged as a result of the reaction |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Functional annotation and structural characterization of a novel lactonase hydrolyzing D-xylono-1,4-lactone-5-phosphate and L-arabino-1,4-lactone-5-phosphate. | Korczynska M, Xiang DF, Zhang Z, Xu C, Narindoshvili T, Kamat SS, Williams HJ, Chang SS, Kolb P, Hillerich B, Sauder JM, Burley SK, Almo SC, Swaminathan S, Shoichet BK, Raushel FM | 2014 Jul 22 | 24955762 |
| RHEA:44900 | D-galactono-1,4-lactone + H2O = D-galactonate + H(+) |
| RULE(radius=1) | [*:1]-[C;H0;+0:2](=[*:3])-[O;H0;+0:4]-[*:5].[OH2;+0:6]>>([*:1]-[C;H0;+0:2](=[*:3])-[OH;+0:6].[*:5]-[OH;+0:4]) |
| Reaction |  |
| Core-to-Core | No scaffolds atoms were exchanged as a result of the reaction |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Purification and properties of an enzyme in human blood and rat liver microsomes catalyzing the formation and hydrolysis of gamma-lactones. II. Metal ion effects, kinetics, and equilibra. | Fishbein WN, Bessman SP | 1966 Nov 10 | 4958985 |
| Purification and properties of an enzyme in human blood and rat liver microsomes catalyzing the formation and hydrolysis of gamma-lactones. I. Tissue localization, stoichiometry, specificity, distinction from esterase. | Fishbein WN, Bessman SP | 1966 Nov 10 | 4958984 |
| Glucono- -lactonase from Escherichia coli. | Hucho F, Wallenfels K | 1972 Jul 13 | 4625870 |
| RHEA:12745 | a 1,4-lactone + H2O = a 4-hydroxyacid + H(+) |
| RULE(radius=1) | [*:1]-[CH;+0:2](-[*:3])-[O;H0;+0:4]-[*:5].[OH2;+0:6]>>([*:1]-[CH;+0:2](-[*:3])-[OH;+0:6].[*:5]-[OH;+0:4]) |
| Reaction |  |
| Core-to-Core | No scaffolds atoms were exchanged as a result of the reaction |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Purification and properties of an enzyme in human blood and rat liver microsomes catalyzing the formation and hydrolysis of gamma-lactones. II. Metal ion effects, kinetics, and equilibra. | Fishbein WN, Bessman SP | 1966 Nov 10 | 4958985 |
| Purification and properties of an enzyme in human blood and rat liver microsomes catalyzing the formation and hydrolysis of gamma-lactones. I. Tissue localization, stoichiometry, specificity, distinction from esterase. | Fishbein WN, Bessman SP | 1966 Nov 10 | 4958984 |
| Functional annotation and structural characterization of a novel lactonase hydrolyzing D-xylono-1,4-lactone-5-phosphate and L-arabino-1,4-lactone-5-phosphate. | Korczynska M, Xiang DF, Zhang Z, Xu C, Narindoshvili T, Kamat SS, Williams HJ, Chang SS, Kolb P, Hillerich B, Sauder JM, Burley SK, Almo SC, Swaminathan S, Shoichet BK, Raushel FM | 2014 Jul 22 | 24955762 |