EC number:3.1.1.34

Enzyme

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     3. Hydrolases
        3.1 Acting on ester bonds
            3.1.1 Carboxylic-ester hydrolases
ID:3.1.1.34
Description:Lipoprotein lipase.
Alternative Name: Diglyceride lipase.
Diacylglycerol lipase.
Clearing factor lipase.
Prosite: PDOC00110;
PDB:
PDBScop

3D structure

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PDB

References

External Links

UniProtKB Enzyme Link: UniProtKB 3.1.1.34
BRENDA Enzyme Link: BRENDA 3.1.1.34
KEGG Enzyme Link: KEGG3.1.1.34
BioCyc Enzyme Link: BioCyc 3.1.1.34
ExPASy Enzyme Link: ExPASy3.1.1.34
EC2PDB Enzyme Link: EC2PDB 3.1.1.34
ExplorEnz Enzyme Link: ExplorEnz 3.1.1.34
PRIAM enzyme-specific profiles Link: PRIAM 3.1.1.34
IntEnz Enzyme Link: IntEnz 3.1.1.34
MEDLINE Enzyme Link: MEDLINE 3.1.1.34

EC number:3.1.1.34

MSA:

3.1.1.34;
Phylogenetic Tree:

3.1.1.34;
Uniprot:
M-CSA:
RHEA:12044 a triacylglycerol + H2O = a diacylglycerol + a fatty acid + H(+)
RULE(radius=1) [*:1]-[O;H0;+0:2]-[C;H0;+0:3](-[*:4])=[*:5].[OH2;+0:6]>>[*:4]-[C;H0;+0:3](=[*:5])-[OH;+0:6].[*:1]-[OH;+0:2]
Reaction
Core-to-Core No scaffolds atoms were exchanged as a result of the reaction

References

TitleAuthorsDatePubMed ID
Molecular characterization of human ABHD2 as TAG lipase and ester hydrolase.M NK, V B S C T, G K V, B CS, Guntupalli S, J S B2016 Aug27247428
Purification and characterization of a catalytic domain of rat intestinal phospholipase B/lipase associated with brush border membranes.Tojo H, Ichida T, Okamoto M1998 Jan 239442064
Human hepatic and lipoprotein lipase: the loop covering the catalytic site mediates lipase substrate specificity.Dugi KA, Dichek HL, Santamarina-Fojo S1995 Oct 277592706
The TGL2 gene of Saccharomyces cerevisiae encodes an active acylglycerol lipase located in the mitochondria.Ham HJ, Rho HJ, Shin SK, Yoon HJ2010 Jan 2919959834
Expression, regulation, and triglyceride hydrolase activity of Adiponutrin family members.Lake AC, Sun Y, Li JL, Kim JE, Johnson JW, Li D, Revett T, Shih HH, Liu W, Paulsen JE, Gimeno RE2005 Nov16150821
Tgl4p and Tgl5p, two triacylglycerol lipases of the yeast Saccharomyces cerevisiae are localized to lipid particles.Athenstaedt K, Daum G2005 Nov 1116135509
Fat mobilization in adipose tissue is promoted by adipose triglyceride lipase.Zimmermann R, Strauss JG, Haemmerle G, Schoiswohl G, Birner-Gruenberger R, Riederer M, Lass A, Neuberger G, Eisenhaber F, Hermetter A, Zechner R2004 Nov 1915550674
YMR313c/TGL3 encodes a novel triacylglycerol lipase located in lipid particles of Saccharomyces cerevisiae.Athenstaedt K, Daum G2003 Jun 2712682047
Characterization of the lipolytic activity of endothelial lipase.McCoy MG, Sun GS, Marchadier D, Maugeais C, Glick JM, Rader DJ2002 Jun12032167
Hormone-sensitive lipase deficiency in mice causes diglyceride accumulation in adipose tissue, muscle, and testis.Haemmerle G, Zimmermann R, Hayn M, Theussl C, Waeg G, Wagner E, Sattler W, Magin TM, Wagner EF, Zechner R2002 Feb 1511717312
Purification and characterization of bovine pancreatic bile salt-activated lipase.Tanaka H, Mierau I, Ito F1999 May10220579
Saccharomyces cerevisiae lipid droplet associated enzyme Ypr147cp shows both TAG lipase and ester hydrolase activities.M NK, V B S C T, B CS, J S B2018 May 2129491250