EC number:3.1.1.47
| ID: | 3.1.1.47 | ||
|---|---|---|---|
| Description: | 1-alkyl-2-acetylglycerophosphocholine esterase. | ||
| Alternative Name: |
Platelet-activating factor acetylhydrolase. PAF acetylhydrolase. PAF 2-acylhydrolase. LDL-PLA(2). LDL-associated phospholipase A(2). 2-acetyl-1-alkylglycerophosphocholine esterase. | ||
| Prosite: | PDOC00110; | ||
| PDB: |
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||
| Cath: | 3.40.50.1110; 3.40.50.1820; |
3D structure
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External Links
| UniProtKB Enzyme Link: | UniProtKB 3.1.1.47 |
| BRENDA Enzyme Link: | BRENDA 3.1.1.47 |
| KEGG Enzyme Link: | KEGG3.1.1.47 |
| BioCyc Enzyme Link: | BioCyc 3.1.1.47 |
| ExPASy Enzyme Link: | ExPASy3.1.1.47 |
| EC2PDB Enzyme Link: | EC2PDB 3.1.1.47 |
| ExplorEnz Enzyme Link: | ExplorEnz 3.1.1.47 |
| PRIAM enzyme-specific profiles Link: | PRIAM 3.1.1.47 |
| IntEnz Enzyme Link: | IntEnz 3.1.1.47 |
| MEDLINE Enzyme Link: | MEDLINE 3.1.1.47 |
| RHEA:17777 | 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine + H2O = 1-O-alkyl-sn-glycero-3-phosphocholine + acetate + H(+) |
| RULE(radius=1) | [*:1]-[O;H0;+0:2]-[C;H0;+0:3](=[*:4])-[*:5].[OH2;+0:6]>>[*:1]-[OH;+0:2].[*:4]=[C;H0;+0:3](-[*:5])-[OH;+0:6] |
| Reaction |  |
| Core-to-Core | No scaffolds atoms were exchanged as a result of the reaction |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Cloning and expression of cDNA encoding rat liver 60-kDa lysophospholipase containing an asparaginase-like region and ankyrin repeat. | Sugimoto H, Odani S, Yamashita S | 1998 May 15 | 9575212 |
| Hydrolysis and transesterification of platelet-activating factor by lecithin-cholesterol acyltransferase. | Liu M, Subbaiah PV | 1994 Jun 21 | 8016111 |
| Anti-inflammatory properties of a platelet-activating factor acetylhydrolase. | Tjoelker LW, Wilder C, Eberhardt C, Stafforini DM, Dietsch G, Schimpf B, Hooper S, Le Trong H, Cousens LS, Zimmerman GA, Yamada Y, McIntyre TM, Prescott SM, Gray PW | 1995 Apr 6 | 7700381 |
| Plasma platelet activating factor-acetylhydrolase (PAF-AH). | Karasawa K, Harada A, Satoh N, Inoue K, Setaka M | 2003 Mar | 12547653 |
| Platelet-activating factor acetylhydrolase (PAF-AH). | Arai H, Koizumi H, Aoki J, Inoue K | 2002 May | 11983068 |
| Platelet-activating factor acetylhydrolases: broad substrate specificity and lipoprotein binding does not modulate the catalytic properties of the plasma enzyme. | Min JH, Wilder C, Aoki J, Arai H, Inoue K, Paul L, Gelb MH | 2001 Apr 17 | 11294621 |
| Targeted disruption of the murine lecithin:cholesterol acyltransferase gene is associated with reductions in plasma paraoxonase and platelet-activating factor acetylhydrolase activities but not in apolipoprotein J concentration. | Forte TM, Oda MN, Knoff L, Frei B, Suh J, Harmony JA, Stuart WD, Rubin EM, Ng DS | 1999 Jul | 10393212 |
| Molecular basis of the interaction between plasma platelet-activating factor acetylhydrolase and low density lipoprotein. | Stafforini DM, Tjoelker LW, McCormick SP, Vaitkus D, McIntyre TM, Gray PW, Young SG, Prescott SM | 1999 Mar 12 | 10066756 |