EC number:3.1.1.5

Enzyme

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EC Tree
     3. Hydrolases
        3.1 Acting on ester bonds
            3.1.1 Carboxylic-ester hydrolases
ID:3.1.1.5
Description:Lysophospholipase.
Alternative Name: Phospholipase B.
Lysolecithinase.
Lecithinase B.
Prosite: PDOC00279;
PDB:
PDBScop
6FOF 8030773; 8043152; 8030773; 8043152; 8030773; 8043152; 8030773; 8043152; 8030773; 8043152; 8030773; 8043152; 8030773; 8043152; 8030773; 8043152; 8030773; 8043152; 8030773; 8043152; 8030773; 8043152; 8030773; 8043152;
3AYE 8030773; 8043152; 8030773; 8043152;
3AYC 8030773; 8043152; 8030773; 8043152;
3AYA 8030773; 8043152; 8030773; 8043152;
6QGF 8030773; 8043152;
 » show all
Cath: 3.40.1090.10; 3.40.710.10; 2.40.128.130; 2.40.160.20; 3.40.50.1110; 3.40.50.1820; 2.60.40.150;

3D structure

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PDB

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6FOF; 3AYE; 3AYC; 3AYA; 6QGF; 6QGE; 6I77; 6I76; 6I75; 6I74; 6G0V; 6FK2; 6F6Y; 6F2Q; 6EYM; 6EXY; 6EOL; 6EOG; 6B8K; 5ODY; 5OAX; 5NFC; 5NFB; 5NFA; 5NF9; 5NF7; 5IUQ; 5H9R; 5H9P; 5EXO; 5E8A; 5E89; 5E88; 4XBN; 4RL7; 4R9D; 4R9C; 4R9B; 4R9A; 4LBO; 4LBN; 4LBM; 4LBL; 4LBK; 4LBJ; 4JCK; 4JC1; 4BM8; 4BLJ; 4BLI; 3ZSM; 3ZSL; 3ZSK; 3ZSJ; 3T1M; 3T1L; 3AYD; 2XG3; 2NN8; 2NMO; 2NMN; 1KJR; 1KJL; 1A3K; 1WLW; 1WLD; 1WLC; 1IS6; 1IS5; 1IS4; 1IS3; 1ULG; 1ULD; 1ULF; 1ULE; 1ULC; 1UL9; 1C1L; 1C1F; 6A1Y; 6A1X; 6A1V; 6A1T; 6A1S; 5YT4; 5XRP; 5XRO; 5XRN; 5XRM; 5XRL; 5XRK; 5XRJ; 5XRI; 5XRH; 5XRG; 1QKQ; 1LCL; 1HDK; 1G86; 1GAN; 1A78; 1QMJ; 4UW5; 5H9S; 5H9Q; 5GAL; 4Y26; 4XBQ; 4UW6; 4UW4; 4UW3; 3ZXF; 3ZXE; 3GAL; 2GAL; 1BKZ; 5EWS; 5DG1; 5DG2; 1HLC; 1SLC; 1SLB; 1SLT; 1SLA; 4Q26; 3W59; 3W58; 6F83; 6B94; 5MWX; 5MWT; 4Y24; 4Y22; 4Y20; 4Y1Z; 4Y1Y; 4Y1X; 4Y1V; 4XBL; 4Q2F; 4Q27; 4Q1R; 4Q1P; 3T2T; 3OYW; 3OY8; 2ZKN; 2KM2; 1W6Q; 1W6P; 1W6O; 1W6N; 1W6M; 1GZW; 4GAL; 6I78; 6A66; 6A65; 6A64; 6A63; 6A62; 6A1U; 5Y03; 5XG8; 5XG7; 5VWG; 5T7U; 5T7T; 5T7S; 5T7I; 5JPG; 5JP5; 5IT6; 5GZG; 5GZF; 5GZE; 5GZD; 5GZC; 5DUX; 5DUW; 5DUV; 5DUU; 5CBL; 4YM3; 4YM2; 4YM1; 4YM0; 4YLZ; 4Y1U; 4XZP; 4NO4; 4LBQ; 4HAN; 4GXL; 4GA9; 4FQZ; 4BME; 4BMB; 3WV6; 3WLU; 3WG4; 3WG3; 3WG2; 3WG1; 3VKO; 3VKN; 3VKM; 3VKL; 3OJB; 3NV4; 3NV3; 3NV2; 3NV1; 3M3Q; 3M3O; 3M3E; 3M3C; 3M2M; 3LSE; 3LSD; 3I8T; 3DUI; 3B9C; 3APB; 3AP9; 3AP7; 3AP6; 3AP5; 3AP4; 3AFK; 2ZHN; 2ZHM; 2ZHL; 2ZHK; 2ZGU; 2ZGT; 2ZGS; 2ZGR; 2ZGQ; 2ZGP; 2ZGO; 2ZGN; 2ZGM; 2ZGL; 2ZGK; 2YY1; 2YXS; 2YV8; 2YRO; 2WKK; 2R0H; 2R0F; 2JJ6; 2EAL; 2EAK; 2DYC; 2D6P; 2D6O; 2D6N; 2D6M; 2D6L; 2D6K; 1X50; 1WW7; 1WW6; 1WW5; 1WW4;

References

External Links

UniProtKB Enzyme Link: UniProtKB 3.1.1.5
BRENDA Enzyme Link: BRENDA 3.1.1.5
KEGG Enzyme Link: KEGG3.1.1.5
BioCyc Enzyme Link: BioCyc 3.1.1.5
ExPASy Enzyme Link: ExPASy3.1.1.5
EC2PDB Enzyme Link: EC2PDB 3.1.1.5
ExplorEnz Enzyme Link: ExplorEnz 3.1.1.5
PRIAM enzyme-specific profiles Link: PRIAM 3.1.1.5
IntEnz Enzyme Link: IntEnz 3.1.1.5
MEDLINE Enzyme Link: MEDLINE 3.1.1.5

EC number:3.1.1.5

MSA:

3.1.1.5;
Phylogenetic Tree:

3.1.1.5;
Uniprot:
M-CSA:
RHEA:15177 a 1-acyl-sn-glycero-3-phosphocholine + H2O = a fatty acid + H(+) + sn-glycerol 3-phosphocholine
RULE(radius=1) [*:1]-[C;H0;+0:2](=[*:3])-[O;H0;+0:4]-[*:5].[OH2;+0:6]>>[*:1]-[C;H0;+0:2](=[*:3])-[OH;+0:6].[*:5]-[OH;+0:4]
Reaction
Core-to-Core No scaffolds atoms were exchanged as a result of the reaction

References

TitleAuthorsDatePubMed ID
Purification, characterization, and inhibition by phosphatidic acid of lysophospholipase transacylase from rat liver.Sugimoto H, Yamashita S1994 Feb 258119970
The highly selective production of 2-arachidonoyl lysophosphatidylcholine catalyzed by purified calcium-independent phospholipase A2gamma: identification of a novel enzymatic mediator for the generation of a key branch point intermediate in eicosanoid signaling.Yan W, Jenkins CM, Han X, Mancuso DJ, Sims HF, Yang K, Gross RW2005 Jul 2215908428
Human neuropathy target esterase catalyzes hydrolysis of membrane lipids.van Tienhoven M, Atkins J, Li Y, Glynn P2002 Jun 711927584