EC number:3.1.1.64
| ID: | 3.1.1.64 |
|---|---|
| Description: | Retinoid isomerohydrolase. |
| Alternative Name: |
All-trans-retinylester 11-cis isomerohydrolase. All-trans-retinyl-palmitate hydrolase. |
3D structure
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External Links
| UniProtKB Enzyme Link: | UniProtKB 3.1.1.64 |
| BRENDA Enzyme Link: | BRENDA 3.1.1.64 |
| KEGG Enzyme Link: | KEGG3.1.1.64 |
| BioCyc Enzyme Link: | BioCyc 3.1.1.64 |
| ExPASy Enzyme Link: | ExPASy3.1.1.64 |
| EC2PDB Enzyme Link: | EC2PDB 3.1.1.64 |
| ExplorEnz Enzyme Link: | ExplorEnz 3.1.1.64 |
| PRIAM enzyme-specific profiles Link: | PRIAM 3.1.1.64 |
| IntEnz Enzyme Link: | IntEnz 3.1.1.64 |
| MEDLINE Enzyme Link: | MEDLINE 3.1.1.64 |
| RHEA:31775 | all-trans-retinyl hexadecanoate + H2O = 11-cis-retinol + H(+) + hexadecanoate |
| RULE(radius=1) | [*:1]=[C;H0;+0:2](-[*:3])-[O;H0;+0:4]-[*:5].[OH2;+0:6]>>[*:5]-[OH;+0:4].[*:1]=[C;H0;+0:2](-[*:3])-[OH;+0:6] |
| Reaction |  |
| Core-to-Core | No scaffolds atoms were exchanged as a result of the reaction |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Hydrolysis of 11-cis- and all-trans-retinyl palmitate by homogenates of human retinal epithelial cells. | Blaner WS, Das SR, Gouras P, Flood MT | 1987 Jan 5 | 3793734 |
| Purified RPE65 shows isomerohydrolase activity after reassociation with a phospholipid membrane. | Nikolaeva O, Takahashi Y, Moiseyev G, Ma JX | 2009 Jun | 19490105 |
| Identification of key residues determining isomerohydrolase activity of human RPE65. | Takahashi Y, Moiseyev G, Ma JX | 2014 Sep 26 | 25112876 |
| RHEA:31771 | an all-trans-retinyl ester + H2O = 11-cis-retinol + a fatty acid + H(+) |
| RULE(radius=1) | [*:1]-[C;H0;+0:2](=[*:3])-[O;H0;+0:4]-[*:5].[OH2;+0:6]>>[*:1]-[C;H0;+0:2](=[*:3])-[OH;+0:6].[*:5]-[OH;+0:4] |
| Reaction |  |
| Core-to-Core | No scaffolds atoms were exchanged as a result of the reaction |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Fatty acid transport protein 4 (FATP4) prevents light-induced degeneration of cone and rod photoreceptors by inhibiting RPE65 isomerase. | Li S, Lee J, Zhou Y, Gordon WC, Hill JM, Bazan NG, Miner JH, Jin M | 2013 Feb 13 | 23407971 |
| An alternative isomerohydrolase in the retinal Müller cells of a cone-dominant species. | Takahashi Y, Moiseyev G, Chen Y, Nikolaeva O, Ma JX | 2011 Aug | 21676174 |
| Importance of membrane structural integrity for RPE65 retinoid isomerization activity. | Golczak M, Kiser PD, Lodowski DT, Maeda A, Palczewski K | 2010 Mar 26 | 20100834 |
| Crystal structure of native RPE65, the retinoid isomerase of the visual cycle. | Kiser PD, Golczak M, Lodowski DT, Chance MR, Palczewski K | 2009 Oct 13 | 19805034 |
| Purified RPE65 shows isomerohydrolase activity after reassociation with a phospholipid membrane. | Nikolaeva O, Takahashi Y, Moiseyev G, Ma JX | 2009 Jun | 19490105 |
| RPE65 is the isomerohydrolase in the retinoid visual cycle. | Moiseyev G, Chen Y, Takahashi Y, Wu BX, Ma JX | 2005 Aug 30 | 16116091 |
| Rpe65 is the retinoid isomerase in bovine retinal pigment epithelium. | Jin M, Li S, Moghrabi WN, Sun H, Travis GH | 2005 Aug 12 | 16096063 |