Enzyme

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EC Tree
     3. Hydrolases
        3.1 Acting on ester bonds
            3.1.1 Carboxylic-ester hydrolases
ID:3.1.1.77
Description:Acyloxyacyl hydrolase.
Cath: 2.40.160.20;

3D structure

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References

External Links

UniProtKB Enzyme Link: UniProtKB 3.1.1.77
BRENDA Enzyme Link: BRENDA 3.1.1.77
KEGG Enzyme Link: KEGG3.1.1.77
BioCyc Enzyme Link: BioCyc 3.1.1.77
ExPASy Enzyme Link: ExPASy3.1.1.77
EC2PDB Enzyme Link: EC2PDB 3.1.1.77
ExplorEnz Enzyme Link: ExplorEnz 3.1.1.77
PRIAM enzyme-specific profiles Link: PRIAM 3.1.1.77
IntEnz Enzyme Link: IntEnz 3.1.1.77
MEDLINE Enzyme Link: MEDLINE 3.1.1.77
MSA:

3.1.1.77;

Phylogenetic Tree:

3.1.1.77;

Uniprot:
M-CSA:
RHEA:12032 a 3-(acyloxy)acyl derivative of bacterial toxin + H2O = 3-hydroxyacyl derivative of bacterial toxin + a fatty acid + H(+)
RULE(radius=1) [*:1]-[C;H0;+0:2](=[*:3])-[O;H0;+0:4]-[*:5].[OH2;+0:6]>>[*:1]-[C;H0;+0:2](=[*:3])-[OH;+0:6].[*:5]-[OH;+0:4]
Reaction
Core-to-Core No scaffolds atoms were exchanged as a result of the reaction

References

TitleAuthorsDatePubMed ID
Deacylation of structurally diverse lipopolysaccharides by human acyloxyacyl hydrolase.Erwin AL, Munford RS1990 Sep 252398058
Role of pagL and lpxO in Bordetella bronchiseptica lipid A biosynthesis.MacArthur I, Jones JW, Goodlett DR, Ernst RK, Preston A2011 Sep21764941
Expression and characterization of recombinant human acyloxyacyl hydrolase, a leukocyte enzyme that deacylates bacterial lipopolysaccharides.Hagen FS, Grant FJ, Kuijper JL, Slaughter CA, Moomaw CR, Orth K, O'Hara PJ, Munford RS1991 Aug 271883828
Crystal structure and catalytic mechanism of the LPS 3-O-deacylase PagL from Pseudomonas aeruginosa.Rutten L, Geurtsen J, Lambert W, Smolenaers JJ, Bonvin AM, de Haan A, van der Ley P, Egmond MR, Gros P, Tommassen J2006 May 216632613
The Pseudomonas aeruginosa lipid A deacylase: selection for expression and loss within the cystic fibrosis airway.Ernst RK, Adams KN, Moskowitz SM, Kraig GM, Kawasaki K, Stead CM, Trent MS, Miller SI2006 Jan16352835
Acyloxyacyl hydrolase, a leukocyte enzyme that deacylates bacterial lipopolysaccharides, has phospholipase, lysophospholipase, diacylglycerollipase, and acyltransferase activities in vitro.Munford RS, Hunter JP1992 May 151577781
Dissemination of lipid A deacylases (pagL) among gram-negative bacteria: identification of active-site histidine and serine residues.Geurtsen J, Steeghs L, Hove JT, van der Ley P, Tommassen J2005 Mar 415611102