EC number:3.1.1.78
| ID: | 3.1.1.78 |
|---|---|
| Description: | Polyneuridine-aldehyde esterase. |
| Alternative Name: |
Polyneuridine aldehyde esterase. PNAE. |
| Cath: | 3.40.50.1820; |
3D structure
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External Links
| UniProtKB Enzyme Link: | UniProtKB 3.1.1.78 |
| BRENDA Enzyme Link: | BRENDA 3.1.1.78 |
| KEGG Enzyme Link: | KEGG3.1.1.78 |
| BioCyc Enzyme Link: | BioCyc 3.1.1.78 |
| ExPASy Enzyme Link: | ExPASy3.1.1.78 |
| EC2PDB Enzyme Link: | EC2PDB 3.1.1.78 |
| ExplorEnz Enzyme Link: | ExplorEnz 3.1.1.78 |
| PRIAM enzyme-specific profiles Link: | PRIAM 3.1.1.78 |
| IntEnz Enzyme Link: | IntEnz 3.1.1.78 |
| MEDLINE Enzyme Link: | MEDLINE 3.1.1.78 |
| RHEA:17501 | H2O + polyneuridine aldehyde = 16-epivellosimine + CO2 + methanol |
| RULE(radius=1) | [*:1]-[C;H0;+0:2](-[*:3])(-[*:4])-[C;H0;+0:5](=[*:6])-[O;H0;+0:7]-[CH3;+0:8].[OH2;+0:9]>>[*:1]-[CH;+0:2](-[*:3])-[*:4].[*:6]=[C;H0;+0:5]=[O;H0;+0:7].[CH3;+0:8]-[OH;+0:9] |
| Reaction |  |
| Core-to-Core | No scaffolds atoms were exchanged as a result of the reaction |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Structural basis and enzymatic mechanism of the biosynthesis of C9- from C10-monoterpenoid indole alkaloids. | Yang L, Hill M, Wang M, Panjikar S, Stöckigt J | 2009 | 19496101 |
| Potential active-site residues in polyneuridine aldehyde esterase, a central enzyme of indole alkaloid biosynthesis, by modelling and site-directed mutagenesis. | Mattern-Dogru E, Ma X, Hartmann J, Decker H, Stöckigt J | 2002 Jun | 12071952 |
| The gene encoding polyneuridine aldehyde esterase of monoterpenoid indole alkaloid biosynthesis in plants is an ortholog of the alpha/betahydrolase super family. | Dogru E, Warzecha H, Seibel F, Haebel S, Lottspeich F, Stöckigt J | 2000 Mar | 10691977 |