EC number:3.1.1.79
| ID: | 3.1.1.79 | ||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Description: | Hormone-sensitive lipase. | ||||||||||||||||||
| Alternative Name: |
HSL. | ||||||||||||||||||
| Prosite: | PDOC00903; | ||||||||||||||||||
| PDB: |
» hide |
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| Cath: | 1.10.510.10; 1.10.8.10; 3.30.200.20; 3.30.310.80; |
3D structure
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Note: Use your mouse to drag, rotate, and zoom in and out of the structure. Mouse-over to identify atoms and bonds. Mouse controls documentation.References
External Links
| UniProtKB Enzyme Link: | UniProtKB 3.1.1.79 |
| BRENDA Enzyme Link: | BRENDA 3.1.1.79 |
| KEGG Enzyme Link: | KEGG3.1.1.79 |
| BioCyc Enzyme Link: | BioCyc 3.1.1.79 |
| ExPASy Enzyme Link: | ExPASy3.1.1.79 |
| EC2PDB Enzyme Link: | EC2PDB 3.1.1.79 |
| ExplorEnz Enzyme Link: | ExplorEnz 3.1.1.79 |
| PRIAM enzyme-specific profiles Link: | PRIAM 3.1.1.79 |
| IntEnz Enzyme Link: | IntEnz 3.1.1.79 |
| MEDLINE Enzyme Link: | MEDLINE 3.1.1.79 |
| RHEA:32731 | a diacylglycerol + H2O = a fatty acid + a monoacylglycerol + H(+) |
| RULE(radius=1) | [*:1]-[C;H0;+0:2](=[*:3])-[O;H0;+0:4]-[*:5].[OH2;+0:6]>>[*:1]-[C;H0;+0:2](=[*:3])-[OH;+0:6].[*:5]-[OH;+0:4] |
| Reaction |  |
| Core-to-Core | No scaffolds atoms were exchanged as a result of the reaction |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Hormone-sensitive lipase deficiency in mice causes diglyceride accumulation in adipose tissue, muscle, and testis. | Haemmerle G, Zimmermann R, Hayn M, Theussl C, Waeg G, Wagner E, Sattler W, Magin TM, Wagner EF, Zechner R | 2002 Feb 15 | 11717312 |
| RHEA:15245 | a monoacylglycerol + H2O = a fatty acid + glycerol + H(+) |
| RULE(radius=1) | [*:1]-[C;H0;+0:2](=[*:3])-[O;H0;+0:4]-[*:5].[OH2;+0:6]>>[*:1]-[C;H0;+0:2](=[*:3])-[OH;+0:6].[*:5]-[OH;+0:4] |
| Reaction |  |
| Core-to-Core | No scaffolds atoms were exchanged as a result of the reaction |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Identification of Yju3p as functional orthologue of mammalian monoglyceride lipase in the yeast Saccharomycescerevisiae. | Heier C, Taschler U, Rengachari S, Oberer M, Wolinski H, Natter K, Kohlwein SD, Leber R, Zimmermann R | 2010 Sep | 20554061 |
| RHEA:12044 | a triacylglycerol + H2O = a diacylglycerol + a fatty acid + H(+) |
| RULE(radius=1) | [*:1]-[O;H0;+0:2]-[C;H0;+0:3](-[*:4])=[*:5].[OH2;+0:6]>>[*:4]-[C;H0;+0:3](=[*:5])-[OH;+0:6].[*:1]-[OH;+0:2] |
| Reaction |  |
| Core-to-Core | No scaffolds atoms were exchanged as a result of the reaction |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Molecular characterization of human ABHD2 as TAG lipase and ester hydrolase. | M NK, V B S C T, G K V, B CS, Guntupalli S, J S B | 2016 Aug | 27247428 |
| Purification and characterization of a catalytic domain of rat intestinal phospholipase B/lipase associated with brush border membranes. | Tojo H, Ichida T, Okamoto M | 1998 Jan 23 | 9442064 |
| Human hepatic and lipoprotein lipase: the loop covering the catalytic site mediates lipase substrate specificity. | Dugi KA, Dichek HL, Santamarina-Fojo S | 1995 Oct 27 | 7592706 |
| The TGL2 gene of Saccharomyces cerevisiae encodes an active acylglycerol lipase located in the mitochondria. | Ham HJ, Rho HJ, Shin SK, Yoon HJ | 2010 Jan 29 | 19959834 |
| Expression, regulation, and triglyceride hydrolase activity of Adiponutrin family members. | Lake AC, Sun Y, Li JL, Kim JE, Johnson JW, Li D, Revett T, Shih HH, Liu W, Paulsen JE, Gimeno RE | 2005 Nov | 16150821 |
| Tgl4p and Tgl5p, two triacylglycerol lipases of the yeast Saccharomyces cerevisiae are localized to lipid particles. | Athenstaedt K, Daum G | 2005 Nov 11 | 16135509 |
| Fat mobilization in adipose tissue is promoted by adipose triglyceride lipase. | Zimmermann R, Strauss JG, Haemmerle G, Schoiswohl G, Birner-Gruenberger R, Riederer M, Lass A, Neuberger G, Eisenhaber F, Hermetter A, Zechner R | 2004 Nov 19 | 15550674 |
| YMR313c/TGL3 encodes a novel triacylglycerol lipase located in lipid particles of Saccharomyces cerevisiae. | Athenstaedt K, Daum G | 2003 Jun 27 | 12682047 |
| Characterization of the lipolytic activity of endothelial lipase. | McCoy MG, Sun GS, Marchadier D, Maugeais C, Glick JM, Rader DJ | 2002 Jun | 12032167 |
| Hormone-sensitive lipase deficiency in mice causes diglyceride accumulation in adipose tissue, muscle, and testis. | Haemmerle G, Zimmermann R, Hayn M, Theussl C, Waeg G, Wagner E, Sattler W, Magin TM, Wagner EF, Zechner R | 2002 Feb 15 | 11717312 |
| Purification and characterization of bovine pancreatic bile salt-activated lipase. | Tanaka H, Mierau I, Ito F | 1999 May | 10220579 |
| Saccharomyces cerevisiae lipid droplet associated enzyme Ypr147cp shows both TAG lipase and ester hydrolase activities. | M NK, V B S C T, B CS, J S B | 2018 May 21 | 29491250 |