EC number:3.1.11.7
Enzyme
Download| EC Tree |
| 3. Hydrolases |
| 3.1 Acting on ester bonds |
| 3.1.11 Exodeoxyribonucleases producing 5'-phosphomonoesters |
| ID: | 3.1.11.7 |
|---|---|
| Description: | Adenosine-5'-diphospho-5'-(DNA) diphosphatase. |
| Alternative Name: |
Aprataxin. 5'-app5'-DNA adenylate hydrolase. |
3D structure
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External Links
| UniProtKB Enzyme Link: | UniProtKB 3.1.11.7 |
| BRENDA Enzyme Link: | BRENDA 3.1.11.7 |
| KEGG Enzyme Link: | KEGG3.1.11.7 |
| BioCyc Enzyme Link: | BioCyc 3.1.11.7 |
| ExPASy Enzyme Link: | ExPASy3.1.11.7 |
| EC2PDB Enzyme Link: | EC2PDB 3.1.11.7 |
| ExplorEnz Enzyme Link: | ExplorEnz 3.1.11.7 |
| PRIAM enzyme-specific profiles Link: | PRIAM 3.1.11.7 |
| IntEnz Enzyme Link: | IntEnz 3.1.11.7 |
| MEDLINE Enzyme Link: | MEDLINE 3.1.11.7 |
| RHEA:52132 | adenosine-5'-diphospho-5'-(ribonucleotide)-(DNA) + H2O = 5'-phospho-(ribonucleotide)-(DNA) + AMP + 2 H(+) |
| RULE(radius=1) | [*:1]-[O;H0;+0:2]-[P;H0;+0:3](=[*:4])(-[*:5])-[*:6].[OH2;+0:7]>>[*:1]-[OH;+0:2].[*:4]=[P;H0;+0:3](-[*:5])(-[*:6])-[OH;+0:7] |
| Reaction |  |
| Core-to-Core | |
| Core-to-Core |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Aprataxin resolves adenylated RNA-DNA junctions to maintain genome integrity. | Tumbale P, Williams JS, Schellenberg MJ, Kunkel TA, Williams RS | 2014 Feb 6 | 24362567 |
| The neurodegenerative disease protein aprataxin resolves abortive DNA ligation intermediates. | Ahel I, Rass U, El-Khamisy SF, Katyal S, Clements PM, McKinnon PJ, Caldecott KW, West SC | 2006 Oct 12 | 16964241 |
| RHEA:52128 | adenosine-5'-diphospho-5'-(DNA) + H2O = AMP + 2 H(+) + phospho-5'-(DNA) |
| RULE(radius=1) | [*:1]-[P;H0;+0:2](=[*:3])(-[*:4])-[O;H0;+0:5]-[*:6].[OH2;+0:7]>>[*:6]-[OH;+0:5].[*:1]-[P;H0;+0:2](=[*:3])(-[*:4])-[OH;+0:7] |
| Reaction |  |
| Core-to-Core | |
| Core-to-Core |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Aprataxin resolves adenylated RNA-DNA junctions to maintain genome integrity. | Tumbale P, Williams JS, Schellenberg MJ, Kunkel TA, Williams RS | 2014 Feb 6 | 24362567 |
| The neurodegenerative disease protein aprataxin resolves abortive DNA ligation intermediates. | Ahel I, Rass U, El-Khamisy SF, Katyal S, Clements PM, McKinnon PJ, Caldecott KW, West SC | 2006 Oct 12 | 16964241 |