EC number:3.1.12.2
Enzyme
Download| EC Tree |
| 3. Hydrolases |
| 3.1 Acting on ester bonds |
| 3.1.12 Exodeoxyribonucleases producing 3'-phosphomonoesters |
| ID: | 3.1.12.2 |
|---|---|
| Description: | DNA-3'-diphospho-5'-guanosine diphosphatase. |
| Alternative Name: |
DNA-3'pp5'G guanylate hydrolase. Aprataxin. |
3D structure
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External Links
| UniProtKB Enzyme Link: | UniProtKB 3.1.12.2 |
| BRENDA Enzyme Link: | BRENDA 3.1.12.2 |
| KEGG Enzyme Link: | KEGG3.1.12.2 |
| BioCyc Enzyme Link: | BioCyc 3.1.12.2 |
| ExPASy Enzyme Link: | ExPASy3.1.12.2 |
| EC2PDB Enzyme Link: | EC2PDB 3.1.12.2 |
| ExplorEnz Enzyme Link: | ExplorEnz 3.1.12.2 |
| PRIAM enzyme-specific profiles Link: | PRIAM 3.1.12.2 |
| IntEnz Enzyme Link: | IntEnz 3.1.12.2 |
| MEDLINE Enzyme Link: | MEDLINE 3.1.12.2 |
| RHEA:52140 | (DNA)-3'-diphospho-5'-guanosine + H2O = (DNA)-3'-phosphate + GMP + 2 H(+) |
| RULE(radius=1) | [*:1]-[P;H0;+0:2](=[*:3])(-[*:4])-[O;H0;+0:5]-[*:6].[OH2;+0:7]>>[*:6]-[OH;+0:5].[*:1]-[P;H0;+0:2](=[*:3])(-[*:4])-[OH;+0:7] |
| Reaction |  |
| Core-to-Core | |
| Core-to-Core |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| DNA3'pp5'G de-capping activity of aprataxin: effect of cap nucleoside analogs and structural basis for guanosine recognition. | Chauleau M, Jacewicz A, Shuman S | 2015 Jul 13 | 26007660 |
| Impact of DNA3'pp5'G capping on repair reactions at DNA 3' ends. | Das U, Chauleau M, Ordonez H, Shuman S | 2014 Aug 5 | 25049385 |