EC number:3.1.2.14
| ID: | 3.1.2.14 |
|---|---|
| Description: | Oleoyl-[acyl-carrier-protein] hydrolase. |
| Alternative Name: |
S-acyl fatty acid synthase thioesterase. Acyl-[acyl-carrier-protein] hydrolase. |
| Cath: | 1.10.110.40; 1.10.1200.10; 1.10.1470.20; 1.10.287.1960; 1.10.287.3140; 1.20.1050.120; 1.20.5.3540; 3.20.20.70; 3.30.1120.10; 3.30.1120.100; |
3D structure
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External Links
| UniProtKB Enzyme Link: | UniProtKB 3.1.2.14 |
| BRENDA Enzyme Link: | BRENDA 3.1.2.14 |
| KEGG Enzyme Link: | KEGG3.1.2.14 |
| BioCyc Enzyme Link: | BioCyc 3.1.2.14 |
| ExPASy Enzyme Link: | ExPASy3.1.2.14 |
| EC2PDB Enzyme Link: | EC2PDB 3.1.2.14 |
| ExplorEnz Enzyme Link: | ExplorEnz 3.1.2.14 |
| PRIAM enzyme-specific profiles Link: | PRIAM 3.1.2.14 |
| IntEnz Enzyme Link: | IntEnz 3.1.2.14 |
| MEDLINE Enzyme Link: | MEDLINE 3.1.2.14 |
| RHEA:15057 | (9Z)-octadecenoyl-[ACP] + H2O = (9Z)-octadecenoate + H(+) + holo-[ACP] |
| RULE(radius=1) | [*:1]-[S;H0;+0:2]-[C;H0;+0:3](=[*:4])-[*:5].[OH2;+0:6]>>[*:1]-[SH;+0:2].[*:4]=[C;H0;+0:3](-[*:5])-[OH;+0:6] |
| Reaction |  |
| Core-to-Core | No scaffolds atoms were exchanged as a result of the reaction |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Purification and properties of fatty acyl thioesterase I from Escherichia coli. | Bonner WM, Bloch K | 1972 May 25 | 4554913 |
| Fat metabolism in higher plants. The function of acyl thioesterases in the metabolism of acyl-coenzymes A and acyl-acyl carrier proteins. | Shine WE, Mancha M, Stumpf PK | 1976 Jan | 3134 |
| Fat metabolism in higher plants. Characterization of plant acyl-ACP and acyl-CoA hydrolases. | Ohlrogge JB, Shine WE, Stumpf PK | 1978 Aug | 30409 |
| Hexanoate synthase, a specialized type I fatty acid synthase in aflatoxin B1 biosynthesis. | Hitchman TS, Schmidt EW, Trail F, Rarick MD, Linz JE, Townsend CA | 2001 Oct | 16256699 |
| Characterization of substrate specificity of plant FatA and FatB acyl-ACP thioesterases. | Salas JJ, Ohlrogge JB | 2002 Jul 1 | 12061798 |
| Human fatty acid synthase: properties and molecular cloning. | Jayakumar A, Tai MH, Huang WY, al-Feel W, Hsu M, Abu-Elheiga L, Chirala SS, Wakil SJ | 1995 Sep 12 | 7567999 |
| RHEA:30123 | H2O + tetradecanoyl-[ACP] = H(+) + holo-[ACP] + tetradecanoate |
| RULE(radius=1) | [*:1]-[S;H0;+0:2]-[C;H0;+0:3](=[*:4])-[*:5].[OH2;+0:6]>>[*:1]-[SH;+0:2].[*:4]=[C;H0;+0:3](-[*:5])-[OH;+0:6] |
| Reaction |  |
| Core-to-Core | No scaffolds atoms were exchanged as a result of the reaction |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| The enigmatic acyl carrier protein phosphodiesterase of Escherichia coli: genetic and enzymological characterization. | Thomas J, Cronan JE | 2005 Oct 14 | 16107329 |
| RHEA:30131 | H2O + octanoyl-[ACP] = H(+) + holo-[ACP] + octanoate |
| RULE(radius=1) | [*:1]-[S;H0;+0:2]-[C;H0;+0:3](=[*:4])-[*:5].[OH2;+0:6]>>[*:1]-[SH;+0:2].[*:4]=[C;H0;+0:3](-[*:5])-[OH;+0:6] |
| Reaction |  |
| Core-to-Core | No scaffolds atoms were exchanged as a result of the reaction |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| The enigmatic acyl carrier protein phosphodiesterase of Escherichia coli: genetic and enzymological characterization. | Thomas J, Cronan JE | 2005 Oct 14 | 16107329 |
| RHEA:41932 | H2O + hexadecanoyl-[ACP] = H(+) + hexadecanoate + holo-[ACP] |
| RULE(radius=1) | [*:1]-[S;H0;+0:2]-[C;H0;+0:3](=[*:4])-[*:5].[OH2;+0:6]>>[*:1]-[SH;+0:2].[*:4]=[C;H0;+0:3](-[*:5])-[OH;+0:6] |
| Reaction |  |
| Core-to-Core | No scaffolds atoms were exchanged as a result of the reaction |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Characterization of substrate specificity of plant FatA and FatB acyl-ACP thioesterases. | Salas JJ, Ohlrogge JB | 2002 Jul 1 | 12061798 |
| The enigmatic acyl carrier protein phosphodiesterase of Escherichia coli: genetic and enzymological characterization. | Thomas J, Cronan JE | 2005 Oct 14 | 16107329 |
| Human fatty acid synthase: assembling recombinant halves of the fatty acid synthase subunit protein reconstitutes enzyme activity. | Jayakumar A, Chirala SS, Wakil SJ | 1997 Nov 11 | 9356448 |
| Cloning and expression of the multifunctional human fatty acid synthase and its subdomains in Escherichia coli. | Jayakumar A, Huang WY, Raetz B, Chirala SS, Wakil SJ | 1996 Dec 10 | 8962082 |
| Cloning and expression in Escherichia coli of a novel thioesterase from Arabidopsis thaliana specific for long-chain acyl-acyl carrier proteins. | Dörmann P, Voelker TA, Ohlrogge JB | 1995 Jan 10 | 7840673 |