Enzyme

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     3. Hydrolases
        3.1 Acting on ester bonds
            3.1.2 Thioester hydrolases
ID:3.1.2.2
Description:Palmitoyl-CoA hydrolase.
Alternative Name: Long-chain fatty-acyl-CoA hydrolase.
Prosite: PDOC00112;
PDB:
PDBScop
Cath: 3.40.710.10; 2.40.128.130; 3.40.50.1110; 3.40.50.1820; 2.60.40.2240; 3.10.129.10; 3.10.129.90;

3D structure

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References

External Links

UniProtKB Enzyme Link: UniProtKB 3.1.2.2
BRENDA Enzyme Link: BRENDA 3.1.2.2
KEGG Enzyme Link: KEGG3.1.2.2
BioCyc Enzyme Link: BioCyc 3.1.2.2
ExPASy Enzyme Link: ExPASy3.1.2.2
EC2PDB Enzyme Link: EC2PDB 3.1.2.2
ExplorEnz Enzyme Link: ExplorEnz 3.1.2.2
PRIAM enzyme-specific profiles Link: PRIAM 3.1.2.2
IntEnz Enzyme Link: IntEnz 3.1.2.2
MEDLINE Enzyme Link: MEDLINE 3.1.2.2
MSA:

3.1.2.2;

Phylogenetic Tree:

3.1.2.2;

Uniprot:
M-CSA:
RHEA:16645 H2O + hexadecanoyl-CoA = CoA + H(+) + hexadecanoate
RULE(radius=1) [*:1]=[C;H0;+0:2](-[*:3])-[S;H0;+0:4]-[*:5].[OH2;+0:6]>>[*:5]-[SH;+0:4].[*:1]=[C;H0;+0:2](-[*:3])-[OH;+0:6]
Reaction
Core-to-Core No scaffolds atoms were exchanged as a result of the reaction

References

TitleAuthorsDatePubMed ID
Peroxisome proliferator-induced acyl-CoA thioesterase from rat liver cytosol: molecular cloning and functional expression in Chinese hamster ovary cells.Engberg ST, Aoyama T, Alexson SE, Hashimoto T, Svensson LT1997 Apr 159163348
The thioesterase I of Escherichia coli has arylesterase activity and shows stereospecificity for protease substrates.Lee YL, Chen JC, Shaw JF1997 Feb 139070299
Roles of Ser101, Asp236, and His237 in catalysis of thioesterase II and of the C-terminal region of the enzyme in its interaction with fatty acid synthase.Tai MH, Chirala SS, Wakil SJ1993 Mar 18446599
Purification and properties of long-chain acyl-CoA hydrolases from the liver cytosol of rats treated with peroxisome proliferator.Yamada J, Matsumoto I, Furihata T, Sakuma M, Suga T1994 Jan7906114
Animal fatty acid synthetase. A novel arrangement of the beta-ketoacyl synthetase sites comprising domains of the two subunits.Stoops JK, Wakil SJ1981 May 256112225
Human brown fat inducible thioesterase variant 2 cellular localization and catalytic function.Chen D, Latham J, Zhao H, Bisoffi M, Farelli J, Dunaway-Mariano D2012 Sep 422897136
Acyl coenzyme A thioesterase Them5/Acot15 is involved in cardiolipin remodeling and fatty liver development.Zhuravleva E, Gut H, Hynx D, Marcellin D, Bleck CK, Genoud C, Cron P, Keusch JJ, Dummler B, Esposti MD, Hemmings BA2012 Jul22586271
The Akt C-terminal modulator protein is an acyl-CoA thioesterase of the Hotdog-Fold family.Zhao H, Martin BM, Bisoffi M, Dunaway-Mariano D2009 Jun 2319453107
Mycobacterium tuberculosis Rv3802c encodes a phospholipase/thioesterase and is inhibited by the antimycobacterial agent tetrahydrolipstatin.Parker SK, Barkley RM, Rino JG, Vasil ML200919169353
Identification and characterization of Escherichia coli thioesterase III that functions in fatty acid beta-oxidation.Nie L, Ren Y, Schulz H2008 Jul 2218576672
Identification of a type III thioesterase reveals the function of an operon crucial for Mtb virulence.Wang F, Langley R, Gulten G, Wang L, Sacchettini JC2007 May17524985
Analysis of the mouse and human acyl-CoA thioesterase (ACOT) gene clusters shows that convergent, functional evolution results in a reduced number of human peroxisomal ACOTs.Hunt MC, Rautanen A, Westin MA, Svensson LT, Alexson SE2006 Sep16940157
The human bile acid-CoA:amino acid N-acyltransferase functions in the conjugation of fatty acids to glycine.O'Byrne J, Hunt MC, Rai DK, Saeki M, Alexson SE2003 Sep 512810727
Characterization of an acyl-coA thioesterase that functions as a major regulator of peroxisomal lipid metabolism.Hunt MC, Solaas K, Kase BF, Alexson SE2002 Jan 1111673457
Biochemical and Structural Characterization of TesA, a Major Thioesterase Required for Outer-Envelope Lipid Biosynthesis in Mycobacterium tuberculosis.Nguyen PC, Nguyen VS, Martin BP, Fourquet P, Camoin L, Spilling CD, Cavalier JF, Cambillau C, Canaan S2018 Dec 730292819