EC number:3.1.2.22
| ID: | 3.1.2.22 |
|---|---|
| Description: | Palmitoyl-protein hydrolase. |
| Alternative Name: |
Palmitoyl-protein thioesterase. |
| Cath: | 3.40.50.1820; |
3D structure
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External Links
| UniProtKB Enzyme Link: | UniProtKB 3.1.2.22 |
| BRENDA Enzyme Link: | BRENDA 3.1.2.22 |
| KEGG Enzyme Link: | KEGG3.1.2.22 |
| BioCyc Enzyme Link: | BioCyc 3.1.2.22 |
| ExPASy Enzyme Link: | ExPASy3.1.2.22 |
| EC2PDB Enzyme Link: | EC2PDB 3.1.2.22 |
| ExplorEnz Enzyme Link: | ExplorEnz 3.1.2.22 |
| PRIAM enzyme-specific profiles Link: | PRIAM 3.1.2.22 |
| IntEnz Enzyme Link: | IntEnz 3.1.2.22 |
| MEDLINE Enzyme Link: | MEDLINE 3.1.2.22 |
| RHEA:19233 | H2O + S-hexadecanoyl-L-cysteinyl-[protein] = H(+) + hexadecanoate + L-cysteinyl-[protein] |
| RULE(radius=1) | [*:1]=[C;H0;+0:2](-[*:3])-[S;H0;+0:4]-[*:5].[OH2;+0:6]>>[*:5]-[SH;+0:4].[*:1]=[C;H0;+0:2](-[*:3])-[OH;+0:6] |
| Reaction |  |
| Core-to-Core | No scaffolds atoms were exchanged as a result of the reaction |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| cDNA and genomic cloning of human palmitoyl-protein thioesterase (PPT), the enzyme defective in infantile neuronal ceroid lipofuscinosis. | Schriner JE, Yi W, Hofmann SL | 1996 Jun 15 | 8786130 |
| Lysosomal targeting of palmitoyl-protein thioesterase. | Verkruyse LA, Hofmann SL | 1996 Jun 28 | 8663305 |
| Assay and isolation of palmitoyl-protein thioesterase from bovine brain using palmitoylated H-Ras as substrate. | Camp LA, Hofmann SL | 1995 | 7651163 |
| pdf1, a palmitoyl protein thioesterase 1 Ortholog in Schizosaccharomyces pombe: a yeast model of infantile Batten disease. | Cho SK, Hofmann SL | 2004 Apr | 15075260 |
| The crystal structure of palmitoyl protein thioesterase 1 and the molecular basis of infantile neuronal ceroid lipofuscinosis. | Bellizzi JJ 3rd, Widom J, Kemp C, Lu JY, Das AK, Hofmann SL, Clardy J | 2000 Apr 25 | 10781062 |