Enzyme

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EC Tree
     3. Hydrolases
        3.1 Acting on ester bonds
            3.1.3 Phosphoric-monoester hydrolases
ID:3.1.3.100
Description:Thiamine phosphate phosphatase.

3D structure

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References

External Links

UniProtKB Enzyme Link: UniProtKB 3.1.3.100
BRENDA Enzyme Link: BRENDA 3.1.3.100
KEGG Enzyme Link: KEGG3.1.3.100
BioCyc Enzyme Link: BioCyc 3.1.3.100
ExPASy Enzyme Link: ExPASy3.1.3.100
EC2PDB Enzyme Link: EC2PDB 3.1.3.100
ExplorEnz Enzyme Link: ExplorEnz 3.1.3.100
PRIAM enzyme-specific profiles Link: PRIAM 3.1.3.100
IntEnz Enzyme Link: IntEnz 3.1.3.100
MEDLINE Enzyme Link: MEDLINE 3.1.3.100
MSA:

3.1.3.100;

Phylogenetic Tree:

3.1.3.100;

Uniprot:
M-CSA:
RHEA:47948 H2O + thiamine phosphate = phosphate + thiamine
RULE(radius=1) [*:1]=[P;H0;+0:2](-[*:3])(-[*:4])-[O;H0;+0:5]-[*:6].[OH2;+0:7]>>[*:6]-[OH;+0:5].[*:1]=[P;H0;+0:2](-[*:3])(-[*:4])-[OH;+0:7]
Reaction
Core-to-Core No scaffolds atoms were exchanged as a result of the reaction

References

TitleAuthorsDatePubMed ID
Arabidopsis TH2 Encodes the Orphan Enzyme Thiamin Monophosphate Phosphatase.Mimura M, Zallot R, Niehaus TD, Hasnain G, Gidda SK, Nguyen TN, Anderson EM, Mullen RT, Brown G, Yakunin AF, de Crécy-Lagard V, Gregory JF 3rd, McCarty DR, Hanson AD2016 Oct27677881
Bacterial and plant HAD enzymes catalyse a missing phosphatase step in thiamin diphosphate biosynthesis.Hasnain G, Roje S, Sa N, Zallot R, Ziemak MJ, de Crécy-Lagard V, Gregory JF 3rd, Hanson AD2016 Jan 1526537753
[Identification of thiamine monophosphate hydrolyzing enzymes in chicken liver].Kolos IK, Makarchikov AF2014 Nov-Dec25816604
The vitamin B1 metabolism of Staphylococcus aureus is controlled at enzymatic and transcriptional levels.Müller IB, Bergmann B, Groves MR, Couto I, Amaral L, Begley TP, Walter RD, Wrenger C2009 Nov 319888457
Thiamine in Schizosaccharomyces pombe: dephosphorylation, intracellular pool, biosynthesis and transport.Schweingruber AM, Dlugonski J, Edenharter E, Schweingruber ME1991 Apr1868574
Pathway of thiamine pyrophosphate synthesis in Micrococcus denitrificans.Sanemori H, Egi Y, Kawasaki T1976 Jun181359
High affinity of acid phosphatase encoded by PHO3 gene in Saccharomyces cerevisiae for thiamin phosphates.Nosaka K1990 Feb 92407294
A th-1 Mutant of Arabidopsis thaliana Is Defective for a Thiamin-Phosphate-Synthesizing Enzyme: Thiamin Phosphate Pyrophosphorylase.Komeda Y, Tanaka M, Nishimune T1988 Oct16666289