EC number:3.1.3.25
Enzyme
Download| EC Tree |
| 3. Hydrolases |
| 3.1 Acting on ester bonds |
| 3.1.3 Phosphoric-monoester hydrolases |
3D structure
Click one PDB to see exact 3D structure provided by NGL.
Note: Use your mouse to drag, rotate, and zoom in and out of the structure. Mouse-over to identify atoms and bonds. Mouse controls documentation.| PDB |
6B66;
6B65;
6B64;
6B63;
6B62;
6B61;
6B60;
6B5Z;
1LBZ;
1LBY;
1LBX;
1LBW;
1LBV;
1QGX;
1KA1;
1KA0;
1K9Z;
1K9Y;
1INP;
6GJ0;
6GIU;
4AS4;
2HHM;
1IME;
1IMD;
1IMC;
1IMB;
1IMA;
1AWB;
1IMF;
1JP4;
1G0I;
1G0H;
1DK4;
6IB8;
6IB7;
5ZON;
5YHT;
5ESY;
5DJK;
5DJJ;
5DJI;
5DJH;
5DJG;
5DJF;
4AS5;
2WEF;
2QFL;
2Q74;
2PCR;
2P3V;
2P3N;
2FVZ;
2DDK;
2CZK;
2CZI;
2CZH;
2BJI;
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References
External Links
| UniProtKB Enzyme Link: | UniProtKB 3.1.3.25 |
| BRENDA Enzyme Link: | BRENDA 3.1.3.25 |
| KEGG Enzyme Link: | KEGG3.1.3.25 |
| BioCyc Enzyme Link: | BioCyc 3.1.3.25 |
| ExPASy Enzyme Link: | ExPASy3.1.3.25 |
| EC2PDB Enzyme Link: | EC2PDB 3.1.3.25 |
| ExplorEnz Enzyme Link: | ExplorEnz 3.1.3.25 |
| PRIAM enzyme-specific profiles Link: | PRIAM 3.1.3.25 |
| IntEnz Enzyme Link: | IntEnz 3.1.3.25 |
| MEDLINE Enzyme Link: | MEDLINE 3.1.3.25 |
| RHEA:24056 | a myo-inositol phosphate + H2O = myo-inositol + phosphate |
| RULE(radius=1) | [*:1]=[P;H0;+0:2](-[*:3])(-[*:4])-[O;H0;+0:5]-[*:6].[OH2;+0:7]>>[*:6]-[OH;+0:5].[*:1]=[P;H0;+0:2](-[*:3])(-[*:4])-[OH;+0:7] |
| Reaction |  |
| Core-to-Core | No scaffolds atoms were exchanged as a result of the reaction |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Rv2131c from Mycobacterium tuberculosis is a CysQ 3'-phosphoadenosine-5'-phosphatase. | Hatzios SK, Iavarone AT, Bertozzi CR | 2008 May 27 | 18454554 |
| Cloning and expression of the inositol monophosphatase gene from Methanococcus jannaschii and characterization of the enzyme. | Chen L, Roberts MF | 1998 Jul | 9647837 |
| Brain inositol monophosphatase identified as a galactose 1-phosphatase. | Parthasarathy R, Parthasarathy L, Vadnal R | 1997 Dec 5 | 9462881 |
| A novel human myo-inositol monophosphatase gene, IMP.18p, maps to a susceptibility region for bipolar disorder. | Yoshikawa T, Turner G, Esterling LE, Sanders AR, Detera-Wadleigh SD | 1997 Sep | 9322233 |
| The contribution of lysine-36 to catalysis by human myo-inositol monophosphatase. | Ganzhorn AJ, Lepage P, Pelton PD, Strasser F, Vincendon P, Rondeau JM | 1996 Aug 20 | 8718889 |
| Plant inositol monophosphatase is a lithium-sensitive enzyme encoded by a multigene family. | Gillaspy GE, Keddie JS, Oda K, Gruissem W | 1995 Dec | 8718627 |
| Structural analysis of inositol monophosphatase complexes with substrates. | Bone R, Frank L, Springer JP, Pollack SJ, Osborne SA, Atack JR, Knowles MR, McAllister G, Ragan CI, Broughton HB | 1994 Aug 16 | 8068620 |
| D-myoinositol 1-phosphate as product of cyclization of glucose 6-phosphate and substrate for a specific phosphatase in rat testis. | Eisenberg F Jr | 1967 Apr 10 | 4290245 |
| The purification and properties of myo-inositol monophosphatase from bovine brain. | Gee NS, Ragan CI, Watling KJ, Aspley S, Jackson RG, Reid GG, Gani D, Shute JK | 1988 Feb 1 | 2833231 |
| Spatiotemporal control of phosphatidylinositol 4-phosphate by Sac2 regulates endocytic recycling. | Hsu F, Hu F, Mao Y | 2015 Apr 13 | 25869669 |
| Sac2/INPP5F is an inositol 4-phosphatase that functions in the endocytic pathway. | Nakatsu F, Messa M, Nández R, Czapla H, Zou Y, Strittmatter SM, De Camilli P | 2015 Apr 13 | 25869668 |
| VTC4 is a bifunctional enzyme that affects myoinositol and ascorbate biosynthesis in plants. | Torabinejad J, Donahue JL, Gunesekera BN, Allen-Daniels MJ, Gillaspy GE | 2009 Jun | 19339506 |
| Rv2131c gene product: an unconventional enzyme that is both inositol monophosphatase and fructose-1,6-bisphosphatase. | Gu X, Chen M, Shen H, Jiang X, Huang Y, Wang H | 2006 Jan 20 | 16325768 |
| A highly specific L-galactose-1-phosphate phosphatase on the path to ascorbate biosynthesis. | Laing WA, Bulley S, Wright M, Cooney J, Jensen D, Barraclough D, MacRae E | 2004 Nov 30 | 15550539 |
| cDNA cloning of human and rat brain myo-inositol monophosphatase. Expression and characterization of the human recombinant enzyme. | McAllister G, Whiting P, Hammond EA, Knowles MR, Atack JR, Bailey FJ, Maigetter R, Ragan CI | 1992 Jun 15 | 1377913 |
| Crystal structure of a dual activity IMPase/FBPase (AF2372) from Archaeoglobus fulgidus. The story of a mobile loop. | Stieglitz KA, Johnson KA, Yang H, Roberts MF, Seaton BA, Head JF, Stec B | 2002 Jun 21 | 11940584 |
| Purification and biochemical characterization of Mycobacterium tuberculosis SuhB, an inositol monophosphatase involved in inositol biosynthesis. | Nigou J, Dover LG, Besra GS | 2002 Apr 2 | 11914086 |
| MJ0109 is an enzyme that is both an inositol monophosphatase and the 'missing' archaeal fructose-1,6-bisphosphatase. | Stec B, Yang H, Johnson KA, Chen L, Roberts MF | 2000 Nov | 11062561 |
| Overexpression, purification, and analysis of complementation behavior of E. coli SuhB protein: comparison with bacterial and archaeal inositol monophosphatases. | Chen L, Roberts MF | 2000 Apr 11 | 10747806 |
| Characterization of a tetrameric inositol monophosphatase from the hyperthermophilic bacterium Thermotoga maritima. | Chen L, Roberts MF | 1999 Oct | 10508089 |
| RHEA:27670 | 1D-myo-inositol 1-phosphate + H2O = myo-inositol + phosphate |
| RULE(radius=1) | [*:1]=[P;H0;+0:2](-[*:3])(-[*:4])-[O;H0;+0:5]-[*:6].[OH2;+0:7]>>[*:6]-[OH;+0:5].[*:1]=[P;H0;+0:2](-[*:3])(-[*:4])-[OH;+0:7] |
| Reaction |  |
| Core-to-Core | No scaffolds atoms were exchanged as a result of the reaction |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| A novel human myo-inositol monophosphatase gene, IMP.18p, maps to a susceptibility region for bipolar disorder. | Yoshikawa T, Turner G, Esterling LE, Sanders AR, Detera-Wadleigh SD | 1997 Sep | 9322233 |
| D-myoinositol 1-phosphate as product of cyclization of glucose 6-phosphate and substrate for a specific phosphatase in rat testis. | Eisenberg F Jr | 1967 Apr 10 | 4290245 |
| The purification and properties of myo-inositol monophosphatase from bovine brain. | Gee NS, Ragan CI, Watling KJ, Aspley S, Jackson RG, Reid GG, Gani D, Shute JK | 1988 Feb 1 | 2833231 |
| RHEA:30735 | 1D-myo-inositol 4-phosphate + H2O = myo-inositol + phosphate |
| RULE(radius=1) | [*:1]=[P;H0;+0:2](-[*:3])(-[*:4])-[O;H0;+0:5]-[*:6].[OH2;+0:7]>>[*:6]-[OH;+0:5].[*:1]=[P;H0;+0:2](-[*:3])(-[*:4])-[OH;+0:7] |
| Reaction |  |
| Core-to-Core | No scaffolds atoms were exchanged as a result of the reaction |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| A novel human myo-inositol monophosphatase gene, IMP.18p, maps to a susceptibility region for bipolar disorder. | Yoshikawa T, Turner G, Esterling LE, Sanders AR, Detera-Wadleigh SD | 1997 Sep | 9322233 |
| D-myoinositol 1-phosphate as product of cyclization of glucose 6-phosphate and substrate for a specific phosphatase in rat testis. | Eisenberg F Jr | 1967 Apr 10 | 4290245 |
| The purification and properties of myo-inositol monophosphatase from bovine brain. | Gee NS, Ragan CI, Watling KJ, Aspley S, Jackson RG, Reid GG, Gani D, Shute JK | 1988 Feb 1 | 2833231 |
| RHEA:30739 | 1D-myo-inositol 3-phosphate + H2O = myo-inositol + phosphate |
| RULE(radius=1) | [*:1]=[P;H0;+0:2](-[*:3])(-[*:4])-[O;H0;+0:5]-[*:6].[OH2;+0:7]>>[*:6]-[OH;+0:5].[*:1]=[P;H0;+0:2](-[*:3])(-[*:4])-[OH;+0:7] |
| Reaction |  |
| Core-to-Core | No scaffolds atoms were exchanged as a result of the reaction |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| A novel human myo-inositol monophosphatase gene, IMP.18p, maps to a susceptibility region for bipolar disorder. | Yoshikawa T, Turner G, Esterling LE, Sanders AR, Detera-Wadleigh SD | 1997 Sep | 9322233 |
| D-myoinositol 1-phosphate as product of cyclization of glucose 6-phosphate and substrate for a specific phosphatase in rat testis. | Eisenberg F Jr | 1967 Apr 10 | 4290245 |
| The purification and properties of myo-inositol monophosphatase from bovine brain. | Gee NS, Ragan CI, Watling KJ, Aspley S, Jackson RG, Reid GG, Gani D, Shute JK | 1988 Feb 1 | 2833231 |
| RHEA:44152 | 1D-myo-inositol 2-phosphate + H2O = myo-inositol + phosphate |
| RULE(radius=1) | [*:1]=[P;H0;+0:2](-[*:3])(-[*:4])-[O;H0;+0:5]-[*:6].[OH2;+0:7]>>[*:6]-[OH;+0:5].[*:1]=[P;H0;+0:2](-[*:3])(-[*:4])-[OH;+0:7] |
| Reaction |  |
| Core-to-Core | No scaffolds atoms were exchanged as a result of the reaction |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| A novel human myo-inositol monophosphatase gene, IMP.18p, maps to a susceptibility region for bipolar disorder. | Yoshikawa T, Turner G, Esterling LE, Sanders AR, Detera-Wadleigh SD | 1997 Sep | 9322233 |
| D-myoinositol 1-phosphate as product of cyclization of glucose 6-phosphate and substrate for a specific phosphatase in rat testis. | Eisenberg F Jr | 1967 Apr 10 | 4290245 |
| The purification and properties of myo-inositol monophosphatase from bovine brain. | Gee NS, Ragan CI, Watling KJ, Aspley S, Jackson RG, Reid GG, Gani D, Shute JK | 1988 Feb 1 | 2833231 |
| RHEA:44156 | 1D-myo-inositol 5-phosphate + H2O = myo-inositol + phosphate |
| RULE(radius=1) | [*:1]=[P;H0;+0:2](-[*:3])(-[*:4])-[O;H0;+0:5]-[*:6].[OH2;+0:7]>>[*:6]-[OH;+0:5].[*:1]=[P;H0;+0:2](-[*:3])(-[*:4])-[OH;+0:7] |
| Reaction |  |
| Core-to-Core | No scaffolds atoms were exchanged as a result of the reaction |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| A novel human myo-inositol monophosphatase gene, IMP.18p, maps to a susceptibility region for bipolar disorder. | Yoshikawa T, Turner G, Esterling LE, Sanders AR, Detera-Wadleigh SD | 1997 Sep | 9322233 |
| D-myoinositol 1-phosphate as product of cyclization of glucose 6-phosphate and substrate for a specific phosphatase in rat testis. | Eisenberg F Jr | 1967 Apr 10 | 4290245 |
| The purification and properties of myo-inositol monophosphatase from bovine brain. | Gee NS, Ragan CI, Watling KJ, Aspley S, Jackson RG, Reid GG, Gani D, Shute JK | 1988 Feb 1 | 2833231 |
| RHEA:44160 | 1D-myo-inositol 6-phosphate + H2O = myo-inositol + phosphate |
| RULE(radius=1) | [*:1]=[P;H0;+0:2](-[*:3])(-[*:4])-[O;H0;+0:5]-[*:6].[OH2;+0:7]>>[*:6]-[OH;+0:5].[*:1]=[P;H0;+0:2](-[*:3])(-[*:4])-[OH;+0:7] |
| Reaction |  |
| Core-to-Core | No scaffolds atoms were exchanged as a result of the reaction |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| A novel human myo-inositol monophosphatase gene, IMP.18p, maps to a susceptibility region for bipolar disorder. | Yoshikawa T, Turner G, Esterling LE, Sanders AR, Detera-Wadleigh SD | 1997 Sep | 9322233 |
| D-myoinositol 1-phosphate as product of cyclization of glucose 6-phosphate and substrate for a specific phosphatase in rat testis. | Eisenberg F Jr | 1967 Apr 10 | 4290245 |
| The purification and properties of myo-inositol monophosphatase from bovine brain. | Gee NS, Ragan CI, Watling KJ, Aspley S, Jackson RG, Reid GG, Gani D, Shute JK | 1988 Feb 1 | 2833231 |