EC number:3.1.3.3
Enzyme
Download| EC Tree |
| 3. Hydrolases |
| 3.1 Acting on ester bonds |
| 3.1.3 Phosphoric-monoester hydrolases |
| ID: | 3.1.3.3 |
|---|---|
| Description: | Phosphoserine phosphatase. |
| Cath: | 1.10.1240.30; 1.10.150.210; 1.20.1440.10; 1.20.1440.100; 3.30.70.20; 3.30.70.2020; 3.30.70.260; 3.60.40.10; 3.90.1470.10; 3.40.50.1000; |
3D structure
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External Links
| UniProtKB Enzyme Link: | UniProtKB 3.1.3.3 |
| BRENDA Enzyme Link: | BRENDA 3.1.3.3 |
| KEGG Enzyme Link: | KEGG3.1.3.3 |
| BioCyc Enzyme Link: | BioCyc 3.1.3.3 |
| ExPASy Enzyme Link: | ExPASy3.1.3.3 |
| EC2PDB Enzyme Link: | EC2PDB 3.1.3.3 |
| ExplorEnz Enzyme Link: | ExplorEnz 3.1.3.3 |
| PRIAM enzyme-specific profiles Link: | PRIAM 3.1.3.3 |
| IntEnz Enzyme Link: | IntEnz 3.1.3.3 |
| MEDLINE Enzyme Link: | MEDLINE 3.1.3.3 |
| RHEA:24873 | H2O + O-phospho-D-serine = D-serine + phosphate |
| RULE(radius=1) | [*:1]-[P;H0;+0:2](-[*:3])(=[*:4])-[O;H0;+0:5]-[*:6].[OH2;+0:7]>>[*:6]-[OH;+0:5].[*:1]-[P;H0;+0:2](-[*:3])(=[*:4])-[OH;+0:7] |
| Reaction |  |
| Core-to-Core | No scaffolds atoms were exchanged as a result of the reaction |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Panoramic view of a superfamily of phosphatases through substrate profiling. | Huang H, Pandya C, Liu C, Al-Obaidi NF, Wang M, Zheng L, Toews Keating S, Aono M, Love JD, Evans B, Seidel RD, Hillerich BS, Garforth SJ, Almo SC, Mariano PS, Dunaway-Mariano D, Allen KN, Farelli JD | 2015 Apr 21 | 25848029 |
| Characterization of M. tuberculosis SerB2, an essential HAD-family phosphatase, reveals novel properties. | Yadav GP, Shree S, Maurya R, Rai N, Singh DK, Srivastava KK, Ramachandran R | 2014 | 25521849 |
| High throughput screen identifies small molecule inhibitors specific for Mycobacterium tuberculosis phosphoserine phosphatase. | Arora G, Tiwari P, Mandal RS, Gupta A, Sharma D, Saha S, Singh R | 2014 Sep 5 | 25037224 |
| Discovery and analysis of cofactor-dependent phosphoglycerate mutase homologs as novel phosphoserine phosphatases in Hydrogenobacter thermophilus. | Chiba Y, Oshima K, Arai H, Ishii M, Igarashi Y | 2012 Apr 6 | 22337887 |
| Genome-wide analysis of substrate specificities of the Escherichia coli haloacid dehalogenase-like phosphatase family. | Kuznetsova E, Proudfoot M, Gonzalez CF, Brown G, Omelchenko MV, Borozan I, Carmel L, Wolf YI, Mori H, Savchenko AV, Arrowsmith CH, Koonin EV, Edwards AM, Yakunin AF | 2006 Nov 24 | 16990279 |
| Chronophin, a novel HAD-type serine protein phosphatase, regulates cofilin-dependent actin dynamics. | Gohla A, Birkenfeld J, Bokoch GM | 2005 Jan | 15580268 |
| How calcium inhibits the magnesium-dependent enzyme human phosphoserine phosphatase. | Peeraer Y, Rabijns A, Collet JF, Van Schaftingen E, De Ranter C | 2004 Aug | 15291819 |
| The thrH gene product of Pseudomonas aeruginosa is a dual activity enzyme with a novel phosphoserine:homoserine phosphotransferase activity. | Singh SK, Yang K, Karthikeyan S, Huynh T, Zhang X, Phillips MA, Zhang H | 2004 Mar 26 | 14699121 |
| High-resolution structure of human phosphoserine phosphatase in open conformation. | Peeraer Y, Rabijns A, Verboven C, Collet JF, Van Schaftingen E, De Ranter C | 2003 Jun | 12777757 |
| Molecular basis for the local conformational rearrangement of human phosphoserine phosphatase. | Kim HY, Heo YS, Kim JH, Park MH, Moon J, Kim E, Kwon D, Yoon J, Shin D, Jeong EJ, Park SY, Lee TG, Jeon YH, Ro S, Cho JM, Hwang KY | 2002 Nov 29 | 12213811 |
| Structural characterization of the reaction pathway in phosphoserine phosphatase: crystallographic "snapshots" of intermediate states. | Wang W, Cho HS, Kim R, Jancarik J, Yokota H, Nguyen HH, Grigoriev IV, Wemmer DE, Kim SH | 2002 May 31 | 12051918 |
| BeF(3)(-) acts as a phosphate analog in proteins phosphorylated on aspartate: structure of a BeF(3)(-) complex with phosphoserine phosphatase. | Cho H, Wang W, Kim R, Yokota H, Damo S, Kim SH, Wemmer D, Kustu S, Yan D | 2001 Jul 17 | 11438683 |
| Plastidic pathway of serine biosynthesis. Molecular cloning and expression of 3-phosphoserine phosphatase from Arabidopsis thaliana. | Ho CL, Noji M, Saito K | 1999 Apr 16 | 10196182 |
| RHEA:21208 | H2O + O-phospho-L-serine = L-serine + phosphate |
| RULE(radius=1) | [*:1]-[P;H0;+0:2](-[*:3])(=[*:4])-[O;H0;+0:5]-[*:6].[OH2;+0:7]>>[*:6]-[OH;+0:5].[*:1]-[P;H0;+0:2](-[*:3])(=[*:4])-[OH;+0:7] |
| Reaction |  |
| Core-to-Core | No scaffolds atoms were exchanged as a result of the reaction |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Panoramic view of a superfamily of phosphatases through substrate profiling. | Huang H, Pandya C, Liu C, Al-Obaidi NF, Wang M, Zheng L, Toews Keating S, Aono M, Love JD, Evans B, Seidel RD, Hillerich BS, Garforth SJ, Almo SC, Mariano PS, Dunaway-Mariano D, Allen KN, Farelli JD | 2015 Apr 21 | 25848029 |
| Characterization of M. tuberculosis SerB2, an essential HAD-family phosphatase, reveals novel properties. | Yadav GP, Shree S, Maurya R, Rai N, Singh DK, Srivastava KK, Ramachandran R | 2014 | 25521849 |
| High throughput screen identifies small molecule inhibitors specific for Mycobacterium tuberculosis phosphoserine phosphatase. | Arora G, Tiwari P, Mandal RS, Gupta A, Sharma D, Saha S, Singh R | 2014 Sep 5 | 25037224 |
| Discovery and analysis of cofactor-dependent phosphoglycerate mutase homologs as novel phosphoserine phosphatases in Hydrogenobacter thermophilus. | Chiba Y, Oshima K, Arai H, Ishii M, Igarashi Y | 2012 Apr 6 | 22337887 |
| Genome-wide analysis of substrate specificities of the Escherichia coli haloacid dehalogenase-like phosphatase family. | Kuznetsova E, Proudfoot M, Gonzalez CF, Brown G, Omelchenko MV, Borozan I, Carmel L, Wolf YI, Mori H, Savchenko AV, Arrowsmith CH, Koonin EV, Edwards AM, Yakunin AF | 2006 Nov 24 | 16990279 |
| Chronophin, a novel HAD-type serine protein phosphatase, regulates cofilin-dependent actin dynamics. | Gohla A, Birkenfeld J, Bokoch GM | 2005 Jan | 15580268 |
| How calcium inhibits the magnesium-dependent enzyme human phosphoserine phosphatase. | Peeraer Y, Rabijns A, Collet JF, Van Schaftingen E, De Ranter C | 2004 Aug | 15291819 |
| The thrH gene product of Pseudomonas aeruginosa is a dual activity enzyme with a novel phosphoserine:homoserine phosphotransferase activity. | Singh SK, Yang K, Karthikeyan S, Huynh T, Zhang X, Phillips MA, Zhang H | 2004 Mar 26 | 14699121 |
| High-resolution structure of human phosphoserine phosphatase in open conformation. | Peeraer Y, Rabijns A, Verboven C, Collet JF, Van Schaftingen E, De Ranter C | 2003 Jun | 12777757 |
| Molecular basis for the local conformational rearrangement of human phosphoserine phosphatase. | Kim HY, Heo YS, Kim JH, Park MH, Moon J, Kim E, Kwon D, Yoon J, Shin D, Jeong EJ, Park SY, Lee TG, Jeon YH, Ro S, Cho JM, Hwang KY | 2002 Nov 29 | 12213811 |
| Structural characterization of the reaction pathway in phosphoserine phosphatase: crystallographic "snapshots" of intermediate states. | Wang W, Cho HS, Kim R, Jancarik J, Yokota H, Nguyen HH, Grigoriev IV, Wemmer DE, Kim SH | 2002 May 31 | 12051918 |
| BeF(3)(-) acts as a phosphate analog in proteins phosphorylated on aspartate: structure of a BeF(3)(-) complex with phosphoserine phosphatase. | Cho H, Wang W, Kim R, Yokota H, Damo S, Kim SH, Wemmer D, Kustu S, Yan D | 2001 Jul 17 | 11438683 |
| Plastidic pathway of serine biosynthesis. Molecular cloning and expression of 3-phosphoserine phosphatase from Arabidopsis thaliana. | Ho CL, Noji M, Saito K | 1999 Apr 16 | 10196182 |