EC number:3.1.3.33
Enzyme
Download| EC Tree |
| 3. Hydrolases |
| 3.1 Acting on ester bonds |
| 3.1.3 Phosphoric-monoester hydrolases |
| ID: | 3.1.3.33 |
|---|---|
| Description: | Polynucleotide 5'-phosphatase. |
| Alternative Name: |
Polynucleotide 5'-triphosphatase. 5'-polynucleotidase. |
| Cath: | 3.20.100.10; 3.20.100.20; 3.30.1490.430; 3.30.470.140; 3.30.470.30; 4.10.87.10; 3.90.190.10; 3.90.70.110; 2.40.50.140; 3.40.220.10; |
3D structure
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External Links
| UniProtKB Enzyme Link: | UniProtKB 3.1.3.33 |
| BRENDA Enzyme Link: | BRENDA 3.1.3.33 |
| KEGG Enzyme Link: | KEGG3.1.3.33 |
| BioCyc Enzyme Link: | BioCyc 3.1.3.33 |
| ExPASy Enzyme Link: | ExPASy3.1.3.33 |
| EC2PDB Enzyme Link: | EC2PDB 3.1.3.33 |
| ExplorEnz Enzyme Link: | ExplorEnz 3.1.3.33 |
| PRIAM enzyme-specific profiles Link: | PRIAM 3.1.3.33 |
| IntEnz Enzyme Link: | IntEnz 3.1.3.33 |
| MEDLINE Enzyme Link: | MEDLINE 3.1.3.33 |
| RHEA:11008 | a 5'-triphospho-(purine-ribonucleotide)-[mRNA] + H2O = a 5'-diphospho-(purine-ribonucleotide)-[mRNA] + H(+) + phosphate |
| RULE(radius=1) | [*:1]-[O;H0;+0:2]-[P;H0;+0:3](=[*:4])(-[*:5])-[*:6].[OH2;+0:7]>>[*:1]-[OH;+0:2].[*:4]=[P;H0;+0:3](-[*:5])(-[*:6])-[OH;+0:7] |
| Reaction |  |
| Core-to-Core | No scaffolds atoms were exchanged as a result of the reaction |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| An RNA 5'-triphosphatase related to the protein tyrosine phosphatases. | Takagi T, Moore CR, Diehn F, Buratowski S | 1997 Jun 13 | 9200605 |
| mRNA capping: biological functions and applications. | Ramanathan A, Robb GB, Chan SH | 2016 Sep 19 | 27317694 |
| Biochemical analysis of the multifunctional vaccinia mRNA capping enzyme encoded by a temperature sensitive virus mutant. | Tate J, Boldt RL, McFadden BD, D'Costa SM, Lewandowski NM, Shatzer AN, Gollnick P, Condit RC | 2016 Jan | 26496697 |
| Enzymology of RNA cap synthesis. | Ghosh A, Lima CD | 2010 Jul-Aug | 21956912 |
| Structural insights to how mammalian capping enzyme reads the CTD code. | Ghosh A, Shuman S, Lima CD | 2011 Jul 22 | 21683636 |
| Chlorella virus RNA triphosphatase. Mutational analysis and mechanism of inhibition by tripolyphosphate. | Gong C, Shuman S | 2002 May 3 | 11844801 |
| Structure and mechanism of the RNA triphosphatase component of mammalian mRNA capping enzyme. | Changela A, Ho CK, Martins A, Shuman S, Mondragón A | 2001 May 15 | 11350947 |
| Structure and mechanism of yeast RNA triphosphatase: an essential component of the mRNA capping apparatus. | Lima CD, Wang LK, Shuman S | 1999 Nov 24 | 10589681 |