EC number:3.1.3.36

Enzyme

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     3. Hydrolases
        3.1 Acting on ester bonds
            3.1.3 Phosphoric-monoester hydrolases
ID:3.1.3.36
Description:Phosphoinositide 5-phosphatase.
Alternative Name: Type II inositol-1,4,5-trisphosphate 5-phosphatase.
Type II inositol polyphosphate 5-phosphatase.
Triphosphoinositide phosphomonoesterase.
Triphosphoinositide phosphatase.
PtdIns(4,5)P(2) phosphatase.
Polyphosphoinositol lipid 5-phosphatase.
Phosphatidylinositol-bisphosphatase.
Phosphatidylinositol 4,5-bisphosphate phosphatase.
Phosphatidyl-myo-inositol-4,5-bisphosphate phosphatase.
Phosphatidyl-inositol-bisphosphate phosphatase.
IP(3) phosphatase.
Inositol triphosphate 5-phosphomonoesterase.
Inositol 1,4,5-triphosphate 5-phosphomonoesterase.
Diphosphoinositide phosphatase.
Cath: 1.10.555.10; 3.30.70.330; 3.60.10.10; 2.30.29.110; 2.60.40.10;

3D structure

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PDB

References

External Links

UniProtKB Enzyme Link: UniProtKB 3.1.3.36
BRENDA Enzyme Link: BRENDA 3.1.3.36
KEGG Enzyme Link: KEGG3.1.3.36
BioCyc Enzyme Link: BioCyc 3.1.3.36
ExPASy Enzyme Link: ExPASy3.1.3.36
EC2PDB Enzyme Link: EC2PDB 3.1.3.36
ExplorEnz Enzyme Link: ExplorEnz 3.1.3.36
PRIAM enzyme-specific profiles Link: PRIAM 3.1.3.36
IntEnz Enzyme Link: IntEnz 3.1.3.36
MEDLINE Enzyme Link: MEDLINE 3.1.3.36

EC number:3.1.3.36

MSA:

3.1.3.36;
Phylogenetic Tree:

3.1.3.36;
Uniprot:
M-CSA:
RHEA:22764 a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + H2O = 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate) + phosphate
RULE(radius=1) [*:1]-[O;H0;+0:2]-[P;H0;+0:3](=[*:4])(-[*:5])-[*:6].[OH2;+0:7]>>[*:1]-[OH;+0:2].[*:4]=[P;H0;+0:3](-[*:5])(-[*:6])-[OH;+0:7]
Reaction
Core-to-Core No scaffolds atoms were exchanged as a result of the reaction

References

TitleAuthorsDatePubMed ID
A new pathway for synthesis of phosphatidylinositol-4,5-bisphosphate.Rameh LE, Tolias KF, Duckworth BC, Cantley LC1997 Nov 139367159
The isolation and characterization of a cDNA encoding phospholipid-specific inositol polyphosphate 5-phosphatase.Kisseleva MV, Wilson MP, Majerus PW2000 Jun 3010764818