EC number:3.1.3.4
Enzyme
Download| EC Tree |
| 3. Hydrolases |
| 3.1 Acting on ester bonds |
| 3.1.3 Phosphoric-monoester hydrolases |
| ID: | 3.1.3.4 |
|---|---|
| Description: | Phosphatidate phosphatase. |
| Alternative Name: |
Phosphatidic acid phosphatase. Phosphatic acid phosphohydrolase. Phosphatic acid phosphatase. Lipin. |
| Cath: | 1.20.144.10; |
3D structure
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External Links
| UniProtKB Enzyme Link: | UniProtKB 3.1.3.4 |
| BRENDA Enzyme Link: | BRENDA 3.1.3.4 |
| KEGG Enzyme Link: | KEGG3.1.3.4 |
| BioCyc Enzyme Link: | BioCyc 3.1.3.4 |
| ExPASy Enzyme Link: | ExPASy3.1.3.4 |
| EC2PDB Enzyme Link: | EC2PDB 3.1.3.4 |
| ExplorEnz Enzyme Link: | ExplorEnz 3.1.3.4 |
| PRIAM enzyme-specific profiles Link: | PRIAM 3.1.3.4 |
| IntEnz Enzyme Link: | IntEnz 3.1.3.4 |
| MEDLINE Enzyme Link: | MEDLINE 3.1.3.4 |
| RHEA:36239 | 1-O-alkyl-2-acyl-sn-glycero-3-phosphate + H2O = 1-O-alkyl-2-acyl-sn-glycerol + phosphate |
| RULE(radius=1) | [*:1]=[P;H0;+0:2](-[*:3])(-[*:4])-[O;H0;+0:5]-[*:6].[OH2;+0:7]>>[*:6]-[OH;+0:5].[*:1]=[P;H0;+0:2](-[*:3])(-[*:4])-[OH;+0:7] |
| Reaction |  |
| Core-to-Core | No scaffolds atoms were exchanged as a result of the reaction |
| RHEA:27429 | a 1,2-diacyl-sn-glycero-3-phosphate + H2O = a 1,2-diacyl-sn-glycerol + phosphate |
| RULE(radius=1) | [*:1]-[O;H0;+0:2]-[P;H0;+0:3](=[*:4])(-[*:5])-[*:6].[OH2;+0:7]>>[*:1]-[OH;+0:2].[*:4]=[P;H0;+0:3](-[*:5])(-[*:6])-[OH;+0:7] |
| Reaction |  |
| Core-to-Core | No scaffolds atoms were exchanged as a result of the reaction |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Isolation and characterization of the Saccharomyces cerevisiae LPP1 gene encoding a Mg2+-independent phosphatidate phosphatase. | Toke DA, Bennett WL, Oshiro J, Wu WI, Voelker DR, Carman GM | 1998 Jun 5 | 9603941 |
| Mammalian Mg2+-independent phosphatidate phosphatase (PAP2) displays diacylglycerol pyrophosphate phosphatase activity. | Dillon DA, Chen X, Zeimetz GM, Wu WI, Waggoner DW, Dewald J, Brindley DN, Carman GM | 1997 Apr 18 | 9099673 |
| Purification and characterization of diacylglycerol pyrophosphate phosphatase from Saccharomyces cerevisiae. | Wu WI, Liu Y, Riedel B, Wissing JB, Fischl AS, Carman GM | 1996 Jan 26 | 8567632 |
| Fracture resistance of endodontically prepared teeth using various restorative materials. | Oliveira Fde C, Denehy GE, Boyer DB | 1987 Jul | 3475370 |
| Phosphatidic acid phosphatase, a key enzyme in the regulation of lipid synthesis. | Carman GM, Han GS | 2009 Jan 30 | 18812320 |
| The Saccharomyces cerevisiae Lipin homolog is a Mg2+-dependent phosphatidate phosphatase enzyme. | Han GS, Wu WI, Carman GM | 2006 Apr 7 | 16467296 |
| Enzymological properties of the LPP1-encoded lipid phosphatase from Saccharomyces cerevisiae. | Furneisen JM, Carman GM | 2000 Feb 24 | 10685032 |