EC number:3.1.3.48

Enzyme

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EC Tree
     3. Hydrolases
        3.1 Acting on ester bonds
            3.1.3 Phosphoric-monoester hydrolases
ID:3.1.3.48
Description:Protein-tyrosine-phosphatase.
Alternative Name: PTPase.
Phosphotyrosine phosphatase.
Prosite: PDOC00323;
PDB:
PDBScop
6D65 8058186; 8058187; 8058186; 8058187;
6D67 8058186; 8058187;
6D66 8058186; 8058187;
6APX 8058186; 8058187;
1LAR 8031973; 8031975; 8044351; 8044353; 8031975; 8044353; 8031973; 8044351;
 » show all
Cath: 1.10.10.430; 1.10.1740.220; 1.10.238.10; 1.10.287.110; 1.10.287.1920; 1.20.120.260; 1.20.5.1840; 1.20.5.2760; 3.20.20.140; 3.30.1570.10;

3D structure

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PDB

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6D65; 6D67; 6D66; 6APX; 1LAR; 4RDD; 4PVG; 3ZM3; 3ZM2; 3ZM1; 3ZM0; 3O5X; 3MOW; 3B7O; 1YFO; 1RPM; 1MKP; 3F81; 1VHR; 1J4X; 2Q47; 1XRI; 1WCH; 5TSR; 2MBC; 1V3A; 1R6H; 1XM2; 1RXD; 5BX1; 1L8K; 4YR8; 1LQF; 5KAD; 4Y14; 4BJO; 3ZMP; 2FJN; 2FJM; 2CM3; 1Q6T; 1Q6S; 1Q6P; 1Q6N; 1JF7; 6CWV; 6CWU; 6BAI; 6B95; 6B90; 6B8Z; 6B8X; 6B8T; 6B8E; 5T19; 5QGF; 5QGE; 5QGD; 5QGC; 5QGB; 5QGA; 5QG9; 5QG8; 5QG7; 5QG6; 5QG5; 5QG4; 5QG3; 5QG2; 5QG1; 5QG0; 5QFZ; 5QFY; 5QFX; 5QFW; 5QFV; 5QFU; 5QFT; 5QFS; 5QFR; 5QFQ; 5QFP; 5QFO; 5QFN; 5QFM; 5QFL; 5QFK; 5QFJ; 5QFI; 5QFG; 5QFF; 5QFE; 5QFD; 5QFC; 5QFB; 5QFA; 5QF9; 5QF8; 5QF7; 5QF6; 5QF5; 5QF4; 5QF3; 5QF2; 5QF1; 5QF0; 5QEZ; 5QEY; 5QEX; 5QEW; 5QEV; 5QEU; 5QET; 5QES; 5QER; 5QEQ; 5QEP; 5QEO; 5QEN; 5QEM; 5QEL; 5QEK; 5QEJ; 5QEI; 5QEH; 5QEG; 5QEF; 5QEE; 5QED; 5QEC; 5QEB; 5QE9; 5QE8; 5QE7; 5QE6; 5QE5; 5QE4; 5QE3; 5QE2; 5QE1; 5QE0; 5QDZ; 5QDY; 5QDX; 5QDW; 5QDV; 5QDU; 5QDS; 5QDR; 5QDQ; 5QDP; 5QDO; 5QDN; 5QDM; 5QDL; 5QDK; 5QDJ; 5QDI; 5QDH; 5QDG; 5QDF; 5QDE; 5KAC; 5KAB; 5KAA; 5KA9; 5KA8; 5KA7; 5KA4; 5KA3; 5KA2; 5KA1; 5KA0; 5K9W; 5K9V; 4ZRT; 4QBW; 4QBE; 4QAP; 4QAH; 4I8N; 3ZV2; 3ZMQ; 3SME; 3QKQ; 3QKP; 3I80; 3I7Z; 3EU0; 3EB1; 3EAX; 3D9C; 3CWE; 3A5K; 3A5J; 2ZN7; 2ZMM; 2VEY; 2VEX; 2VEW; 2VEV; 2VEU; 2QBS; 2QBR; 2QBQ; 2QBP; 2NTA; 2NT7; 2HNQ; 2HNP; 2HB1; 2H4K; 2H4G; 2F71; 2F70; 2F6Z; 2F6Y; 2F6W; 2F6V; 2F6T; 2F6F; 2CNI; 2CNH; 2CNG; 2CNF; 2CNE; 2CMC; 2CMB; 2CMA; 2CM8; 2CM7; 2CM2; 2BGE; 2BGD; 2B07; 2AZR; 1XBO; 1WAX; 1T4J; 1T49; 1T48; 1SUG; 1QXK; 1Q6M; 1Q6J; 1Q1M; 1PYN; 1PXH; 1PTY; 1PTV; 1PTU; 1PTT; 1PH0; 1PA1; 1ONZ; 1ONY; 1OEV; 1OEU; 1OET; 1OES; 1OEO; 1OEM; 1NZ7; 1NWL; 1NWE; 1NO6; 1NNY; 1NL9; 1L8G; 1KAV; 1KAK; 1I57; 1GFY; 1G7G; 1G7F; 1G1H; 1G1G; 1G1F; 1EEO; 1EEN; 1ECV; 1C88; 1C87; 1C86; 1C85; 1C84; 1C83; 1BZH; 1BZC; 1AAX; 1A5Y; 2B4S; 3U96; 1YPT; 1XXV; 1XXP; 4ZN5; 4ZI4; 4Z6B; 4YAA; 3F9B; 3F9A; 3F99; 3BM8; 3BLU; 3BLT; 2I42; 1YTW; 1YTS; 1YTN; 1PA9; 1LYV; 1P15; 1G4U; 1G4W; 6CMQ; 6MDD; 6MDC; 6MDB; 6MDA; 6MD9; 6MD7; 6CRG; 6CRF; 6CMP; 6BN5; 6BMY; 6BMX; 6BMW; 6BMV; 6BMU; 6BMR; 6ATD; 5IBS; 5IBM; 5I6V; 5EHR; 5EHP; 4OHL; 4NWG; 4NWF; 4GWF; 6CMS; 6CMR; 5XZR; 4OHI; 4OHH; 4OHE; 4OHD; 4H34; 4H1O; 4DGX; 4DGP; 1JLN; 1OHE; 1OHD; 1OHC; 1I9T; 1I9S; 1FQ1; 1FPZ; 4HJQ; 4GS0; 4HJP; 4GRZ; 4GRY; 3PS5; 2B3O; 1GWZ; 1FPR; 1M3G; 6H8S; 6H8R; 6G86; 6G85; 6G84; 6D4F; 6D4D; 6D3F; 6BYF; 5Y16; 5Y15; 5XW5; 5XW4; 5XJV; 5QFH; 5QEA; 5QDT; 5OW1; 5OVX; 5OVR; 5MMZ; 5LXQ; 5K25; 5K24; 5K23; 5K22; 5J8R; 5HDE; 5H08; 5GTJ; 5AWX; 4Y2E; 4WOH; 4S0G; 4RI5; 4RI4; 4RHG; 4RH9; 4RH5; 4QUN; 4QUM; 4PYH; 4NYH; 4NND; 4MBB; 4KYR; 4KYQ; 4KI9; 4JNB; 4JMK; 4JMJ; 4J51; 4IKC; 4ICZ; 4HRF; 4GFV; 4GFU; 4GE6; 4GE5; 4GE2; 4ERC; 4D3R; 4D3Q; 4D3P; 4BPC; 4B04; 3SR9; 3S4O; 3S4E; 3S3K; 3S3H; 3S3F; 3S3E; 3RZ2; 3RGQ; 3RGO; 3QCN; 3QCM; 3QCL; 3QCK; 3QCJ; 3QCI; 3QCH; 3QCG; 3QCF; 3QCE; 3QCD; 3QCC; 3QCB; 3OMH; 3OLR; 3O4U; 3O4T; 3O4S; 3NME; 3LJ8; 3H2X; 3EZZ; 3D44; 3D42; 3CM3; 3BRH; 2YF0; 2Y96; 2WGP; 2SHP; 2RF6; 2R0B; 2QEP; 2QDP; 2QDM; 2QDC; 2QCT; 2QCJ; 2Q05; 2PQ5; 2PBN; 2PA5; 2P6X; 2P4D; 2OUD; 2OOQ; 2OC3; 2NZ6; 2NV5; 2NT2; 2NLK; 2JJD; 2J17; 2J16; 2IMG; 2I75; 2I5X; 2I4H; 2I4G; 2I4E; 2I3U; 2I3R; 2I1Y; 2HY3; 2HXP; 2HVL; 2HCM; 2HC2; 2HC1; 2H4V; 2H04; 2H03; 2H02; 2GWO; 2GP0; 2GJT; 2G6Z; 2G59; 2FH7; 2ESB; 2E0T; 2CJZ; 2CFV; 2C7S; 2C46; 2BZL; 2BV5; 2BIJ; 2B49; 2AHS; 2A8B; 2A3K; 1ZZW; 1ZCL; 1ZCK; 1ZC0; 1YZ4; 1YN9; 1YGU; 1YGR; 1X24; 1WRM; 1BZJ;

References

External Links

UniProtKB Enzyme Link: UniProtKB 3.1.3.48
BRENDA Enzyme Link: BRENDA 3.1.3.48
KEGG Enzyme Link: KEGG3.1.3.48
BioCyc Enzyme Link: BioCyc 3.1.3.48
ExPASy Enzyme Link: ExPASy3.1.3.48
EC2PDB Enzyme Link: EC2PDB 3.1.3.48
ExplorEnz Enzyme Link: ExplorEnz 3.1.3.48
PRIAM enzyme-specific profiles Link: PRIAM 3.1.3.48
IntEnz Enzyme Link: IntEnz 3.1.3.48
MEDLINE Enzyme Link: MEDLINE 3.1.3.48

EC number:3.1.3.48

MSA:

3.1.3.48;
Phylogenetic Tree:

3.1.3.48;
Uniprot:
M-CSA:
RHEA:10684 H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate
RULE(radius=1) [*:1]-[O;H0;+0:2]-[P;H0;+0:3](=[*:4])(-[*:5])-[*:6].[OH2;+0:7]>>[*:1]-[OH;+0:2].[*:4]=[P;H0;+0:3](-[*:5])(-[*:6])-[OH;+0:7]
Reaction
Core-to-Core No scaffolds atoms were exchanged as a result of the reaction

References

TitleAuthorsDatePubMed ID
Tyrosylprotein kinase and phosphatase activities in membrane vesicles from normal and Rous sarcoma virus-transformed rat cells.Gallis B, Bornstein P, Brautigan DL1981 Nov6273884
Detection of a novel mammalian protein phosphatase with activity for phosphotyrosine.Foulkes JG, Howard RF, Ziemiecki A1981 Aug 36169552