EC number:3.1.3.56
Enzyme
Download| EC Tree |
| 3. Hydrolases |
| 3.1 Acting on ester bonds |
| 3.1.3 Phosphoric-monoester hydrolases |
| ID: | 3.1.3.56 |
|---|---|
| Description: | Inositol-polyphosphate 5-phosphatase. |
| Alternative Name: |
Type I inositol-polyphosphate phosphatase. Myo-inositol-1,4,5-trisphosphate 5-phosphatase. L-myo-inositol 1,4,5-trisphosphate-monoesterase. InsP(3)/Ins(1,3,4,5)P(4) 5-phosphatase. Ins(1,4,5)P(3) 5-phosphatase. Inositol-1,4,5-trisphosphate/1,3,4,5-tetrakisphosphate 5-phosphatase. Inositol-1,4,5-trisphosphate 5-phosphatase. Inositol trisphosphate phosphomonoesterase. Inositol polyphosphate-5-phosphatase. Inositol phosphate 5-phosphomonoesterase. Inositol 1,4,5-trisphosphate phosphatase. Inosine triphosphatase. D-myo-inositol(1,4,5)/(1,3,4,5)-polyphosphate 5-phosphatase. D-myo-inositol 1,4,5-trisphosphate 5-phosphatase. D-myo-inositol 1,4,5-triphosphate 5-phosphatase. 5PTase. |
| Cath: | 1.10.555.10; 3.30.70.330; 3.60.10.10; 2.30.29.110; 2.60.40.10; |
3D structure
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External Links
| UniProtKB Enzyme Link: | UniProtKB 3.1.3.56 |
| BRENDA Enzyme Link: | BRENDA 3.1.3.56 |
| KEGG Enzyme Link: | KEGG3.1.3.56 |
| BioCyc Enzyme Link: | BioCyc 3.1.3.56 |
| ExPASy Enzyme Link: | ExPASy3.1.3.56 |
| EC2PDB Enzyme Link: | EC2PDB 3.1.3.56 |
| ExplorEnz Enzyme Link: | ExplorEnz 3.1.3.56 |
| PRIAM enzyme-specific profiles Link: | PRIAM 3.1.3.56 |
| IntEnz Enzyme Link: | IntEnz 3.1.3.56 |
| MEDLINE Enzyme Link: | MEDLINE 3.1.3.56 |
| RHEA:19797 | 1D-myo-inositol 1,4,5-trisphosphate + H2O = 1D-myo-inositol 1,4-bisphosphate + phosphate |
| RULE(radius=1) | [*:1]-[O;H0;+0:2]-[P;H0;+0:3](=[*:4])(-[*:5])-[*:6].[OH2;+0:7]>>[*:1]-[OH;+0:2].[*:4]=[P;H0;+0:3](-[*:5])(-[*:6])-[OH;+0:7] |
| Reaction |  |
| Core-to-Core | No scaffolds atoms were exchanged as a result of the reaction |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Molecular and biochemical characterization of three WD-repeat-domain-containing inositol polyphosphate 5-phosphatases in Arabidopsis thaliana. | Zhong R, Ye ZH | 2004 Nov | 15574849 |
| Identification and characterization of a novel inositol polyphosphate 5-phosphatase. | Ijuin T, Mochizuki Y, Fukami K, Funaki M, Asano T, Takenawa T | 2000 Apr 14 | 10753883 |
| Cloning and expression of a human placenta inositol 1,3,4,5-tetrakisphosphate and phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase. | Drayer AL, Pesesse X, De Smedt F, Woscholski R, Parker P, Erneux C | 1996 Aug 5 | 8769125 |
| Molecular characterization of At5PTase1, an inositol phosphatase capable of terminating inositol trisphosphate signaling. | Berdy SE, Kudla J, Gruissem W, Gillaspy GE | 2001 Jun | 11402208 |
| Novel inositol polyphosphate 5-phosphatase localizes at membrane ruffles. | Mochizuki Y, Takenawa T | 1999 Dec 17 | 10593988 |
| RHEA:11392 | 1D-myo-inositol 1,3,4,5-tetrakisphosphate + H2O = 1D-myo-inositol 1,3,4-trisphosphate + phosphate |
| RULE(radius=1) | [*:1]=[P;H0;+0:2](-[*:3])(-[*:4])-[O;H0;+0:5]-[*:6].[OH2;+0:7]>>[*:6]-[OH;+0:5].[*:1]=[P;H0;+0:2](-[*:3])(-[*:4])-[OH;+0:7] |
| Reaction |  |
| Core-to-Core | No scaffolds atoms were exchanged as a result of the reaction |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Purification and molecular cloning of SH2- and SH3-containing inositol polyphosphate-5-phosphatase, which is involved in the signaling pathway of granulocyte-macrophage colony-stimulating factor, erythropoietin, and Bcr-Abl. | Odai H, Sasaki K, Iwamatsu A, Nakamoto T, Ueno H, Yamagata T, Mitani K, Yazaki Y, Hirai H | 1997 Apr 15 | 9108392 |
| Cloning and expression of a human placenta inositol 1,3,4,5-tetrakisphosphate and phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase. | Drayer AL, Pesesse X, De Smedt F, Woscholski R, Parker P, Erneux C | 1996 Aug 5 | 8769125 |
| Molecular characterization of At5PTase1, an inositol phosphatase capable of terminating inositol trisphosphate signaling. | Berdy SE, Kudla J, Gruissem W, Gillaspy GE | 2001 Jun | 11402208 |
| Novel inositol polyphosphate 5-phosphatase localizes at membrane ruffles. | Mochizuki Y, Takenawa T | 1999 Dec 17 | 10593988 |